Explore curated data sets and assays
Pluto has a large database of published data, available to explore, conduct your own analysis, and view QC reports.
Talk to our team for access
Sequencing-based assays (Page 136)
Store large, raw sequencing data files and transform them into biologically-meaningful results in your browser. Gain critical QC information, quantify targets within and across data sets, and run best-in-class computational biology analyses specific to each assay type.
GSE124508: MDM2 and MDM4 are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors
Malignant rhabdoid tumors (MRT) are highly aggressive pediatric cancers that respond poorly to curre...
GSE121950: RNA Sequencing Analysis of villus tissues from unexplained recurrent spontaneous abortion patients and controls with induced abortions
Recurrent spontaneous abortion (RSA), defined as the failure of two or more consecutive clinical pre...
GSE120502: Natural selection has contributed to functional immune response differences between human hunter-gatherers and agriculturalists
The shift from a hunter-gatherer (HG) to an agricultural (AG) mode of subsistence is believed to hav...
GSE123017 (human): Differential requirement for centriolar satellites in cilium formation and ciliary signaling among different vertebrate cells
Centriolar satellites are an array of membrane-less granules that localize and move around the vert...
GSE124558: Differential roles of human PUS10 in miRNA processing and tRNA pseudouridylation
Pseudouridine synthases (PUSs) are responsible for the installation of pseudouridine () modification...
GSE120534: The lung-enriched p53 mutants V157F and R158L/P regulate a novel transcriptome in lung cancer
Lung cancer is the leading cause of cancer-related deaths in the US, and alterations in the tumor su...
GSE121824: SCAF4 and SCAF8, Transcriptional Anti-Terminator Proteins (mRNA-Seq)
Accurate regulation of RNA Polymerase II (RNAPII) transcriptional termination is a prerequisite for ...
GSE120783: Glucocorticoid induced gene signature in human skin
Glucocorticoids (GCs) are among the most effective and frequently prescribed anti-inflammatory drugs...
GSE125916: RNA-sequencing of CD56dim NK cells from atopic dermatitis and control patients
Purpose: To determine the underlying transcriptional differences between CD56dim NK cells from atopi...
GSE128027: Human Eosinophils Express a Distinct Gene Expression Program in Response to IL-3 Compared to Common Beta-Chain Cytokines IL-5 and GM-CSF
Background: Despite recent advances in asthma management with anti-IL-5 therapies, many patients wit...
GSE124084: Human yolk sac-like haematopoiesis generates RUNX1-, GFI1- and/or GFI1B-dependent blood and SOX17-positive endothelium
The genetic regulatory network controlling early fate choices during human blood cell development ar...
GSE120795: Atlas of RNA sequencing profiles of normal human tissues
Comprehensive analysis of molecular pathology requires a collection of reference samples representin...
GSE120862: Contractile activity-specific transcriptome response to acute endurance exercise and training in human skeletal muscle
In our study, we investigated for contractile activity-specific changes in the transcriptome in untr...
GSE123264: Polymyxin nephrotoxicity in kidney chip
Drug-induced kidney injury, largely caused by proximal tubular intoxicants, limits development and c...
GSE124173: RAG1+ multipotent progenitors emerge directly from hemogenic endothelium of human PSC derived haemopoietic organoids [bulk RNA-seq]
The Recombination Activation Gene, RAG1, expression of which presages T-cell receptor gene rearrange...
GSE135497 (human): Targeted single-cell transcriptome readouts for high-throughput genetics and functional genomics
We show that targeted single-cell RNA-sequencing (TAP-seq) permits reliable mapping of cell (sub)typ...
GSE123029: mRNA sequencing of oropharyngeal cancer cell lines
mRNA sequencing was performed on oropharyngeal cancer cell lines including 4 HPV-positive and 4 HPV-...
GSE122058: Prediction of bacterial infection outcome using single cell RNA-seq analysis of human immune cells [WT/TLR10 bulk RNA-seq]
During host-pathogen encounters, the complex interactions between different immune cell-types can de...
GSE125020: Minimum embedding dimension analysis uncovers reduced network complexity during neuronal differentiation in autism spectrum disorder
Background: Neuronal activity can be modeled as a nonlinear dynamical system to yield novel measures...
GSE123936: Accelerated evolution of oligodendrocytes in human brain
Recent discussions of human brain evolution have largely focused on increased neuron numbers and cha...
GSE121843: Small-molecule targeting of brachyury transcription factor addiction in chordoma [rnaseq_compound]
Chordoma is a primary bone cancer with no approved therapy. The identification of therapeutic target...
GSE122334: SPI1/PU.1 controls fibroblast polarization and tissue fibrosis
Fibroblasts are polymorphic cells with pleiotropic roles in organ morphogenesis, tissue homeostasis ...
GSE124409: Nuclear peripheral chromatin-lamin B1 interaction is required for global integrity of chromatin architecture and dynamics in human cells
Background: The eukaryotic genome is folded into higher-order conformation accompanied with constrai...
GSE125917: Global gene expression profiles of cardiomyocytes differentiated from human pluripotent stem cells (hiPSC-CMs) in 3D culture exposed to ethanol
Methods: RNA-seq libraries were prepared using the Illumina TruSeq RNA kit and the TrueSeq method wa...
GSE123074: Mechanistic Model-Guided Study of Embryonic Morphogenesis
We utilize a finite element model of implantation mechanics to guide the in vitro micropatterning hu...
GSE121877: Specifying the Anterior Primitive Streak by Modulating YAP1 Levels in Human Pluripotent Stem Cells
Specifying the primitive streak (PS) guides stem cell differentiation in vitro, however much remains...
GSE123090: RNA-seq with knockdown ZBTB7A and NTC control
Zinc finger and BTB domain containing transcription repressor ZBTB7A has been recently reported as a...
GSE121636: Single-cell sequencing of peripheral blood and tumor-infiltrating immune cells in renal clear cell carcinoma [5' RNA expression sequencing]
We generated a comprehensive immune profile using single-cell RNA-seq data from 25,000 immune cells ...
GSE122093: Spatial clustering and common regulatory elements lead to TGF- induced concerted gene expression
Cellular responses require temporally concerted transcriptional regulation of multiple genes. A sing...
GSE127201: Single-cell RNA sequencing-based CRISPRi screening resolves molecular drivers of early human endoderm development [set 2]
Studies in vertebrates have outlined conserved molecular control of definitive endoderm (END) develo...
GSE125497: CD29 identifies IFN-producing human CD8+ T cells with an increased cytotoxic potential
Cytotoxic CD8+ T cells can effectively kill target cells by producing cytokines, chemokines, and gra...
GSE120944: IFN- selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate M1-like macrophage polarization [RNA-seq]
Complete polarization of macrophages towards an M1-like proinflammatory and antimicrobial state requ...
GSE122708: Selective roles of vertebrate PCF11 in premature and full-length transcript termination (chromatin-bound RNA-seq)
The pervasive nature of RNA polymerase II (Pol II) transcription requires efficient termination. A k...
GSE121105: RNA sequencing of BT474 cells treated with trastuzumab or trastuzumab + pertuzumab and BT474-derived cells resistant to trastuzumab or trastuzumab + pertuzumab
We sequenced untreated BT474 cells, BT474 cells treated for three days with trastuzumab or trastuzum...
GSE125178: Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids
RNA sequencing technology was applied to determine the transcriptional changes due to palmitate trea...
GSE121017: RNA-Seq analysis of cSCC cells followed by siRNA-induced gene knockdown of C1s.
Keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin can...
GSE121926: H3K27ac ChIP-Seq and mRNA-Seq analysis of five human B-lymphoblastoid cell lines (LCLs) prepared from the same healthy male individual (CEPH/UTAH).
Purpose: We examined the extent and nature of non-genetic variability at the gene regulatory activit...
GSE124144: Rnase L reprograms translation by widespread mRNA turnover escaped by antiviral mRNAs
In response to foreign and endogenous double-stranded RNA (dsRNA), protein kinase R (PKR) and ribonu...
GSE126463: mRNA-sequencing for MM.1S cells that were treated with pomalidomide or were expressing shRNA against ARID2 or Aiolos.
To dissect the roles of ARID2 and Aiolos in pomalidomide-induced transcriptional changes, we perfor...
GSE125881: Clonal kinetics and single cell transcriptional profiling of adoptively transferred CD19-specific CD8+ CAR-T cells in adults with B cell malignancies
Lymphodepletion chemotherapy followed by infusion of T cells modified to express a CD19-targeting ch...
GSE122707: RNA-seq approach to study the specific effects of SREBF1-depleting antisense oligonucleotide (ASO) reagent in human melanoma cells.
Purpose: Detailed exploration of de novo Fatty Acid Synthesis (DNFA) transcription regulation and cl...
GSE123777: The mithralog EC-7072 is highly cytotoxic to chronic lymphocytic leukemia cells by targeting the B-cell receptor signaling pathway
EC-7072, an analogue of Mithramycin A, exerts a direct cytotoxic effect on primary leukemic cells fr...
GSE124074: Uncovering the role admixture in health disparities: Association of hepatocyte gene expression and DNA methylation to African Ancestry in African-Americans [RNA-seq]
In African Americans (AA), the proportion of West African ancestry (WAA) may explain the genetic dri...
GSE127935: Early commitment genes drive fast, irreversible commitment to human embryonic stem cell differentiation (RNA-seq data set 1)
The goal of this study was to characterise the earliest transcriptional changes that occur in human ...
GSE123098: Aberrant enhancer reprogramming drives hepatic carcinogenesis through global transcriptional reprogramming [RNA-seq]
Hepatocellular carcinomas (HCC) exhibit distinct promoter hypermethylation patterns, but the epigene...
GSE121327: 3 Uridylation Expands miRNA Target Repertoire
Many microRNAs (miRNAs) exist alongside abundant miRNA isoforms (isomiRs), most of which arise from ...
GSE121049: Tri-mannose grafting of chitosan nanocarriers remodels the macrophage response to bacterial infection
Background: Infectious diseases are still a leading cause of death and, with the emergence of drug r...
GSE123100: Transcriptomic profile alternation of human trabecular meshwork cells under substrate stiffness stimulation
To investigate the transcriptomic profiling of human trabecular meshwork cells by increasing substra...
GSE124607: Development of a selective CDK7 covalent inhibitor reveals predominant cell cycle phenotype
The relationship between promoter proximal transcription factor-associated gene expression and super...
GSE139816: Chromatin dynamics reveal circadian control of human in vitro islet maturation [RNA-seq]
Stem cell-derived tissues could transform disease research and therapy, yet most methods generate fu...
GSE124526: A recurrently amplified long noncoding RNA in colorectal cancer regulates p53 protein stability through GRWD1/RPL11/MDM2 axis [RNA-seq]
By integrating genome-wide copy number alteration, RNA-seq and proteomics data from 589 colorectal c...
GSE124949: Epithelial control of colonisation by Streptococcus pneumoniae at the human mucosal surface
Control of Streptococcus pneumoniae colonisation at human mucosal surfaces is critical to reducing t...
GSE128174: Next Generation Sequencing (RNA-Sequencing) for the analysis of RUNX3 targets in H460, H460-ERT2-RUNX3 WT and H460-ERT2-RUNX3 MT(K94/171R mutation)
Purpose: The goal of this study is to compare the gene expression profiles of H460, H460-ERT2-RUNX3-...
GSE126451: Transcriptomic analysis of the effect of histone H4 K31R mutation in U2OS cells
To explore the genome-wide gene expression changes induced by the K31R mutation in the histone H4 pr...
GSE126042: Single cell analysis of HSV-1 infection reveals anti-viral and developmental programs are activated in distinct sub-populations with opposite outcomes
Viral infection is usually studied at the population level by averaging over millions of cells. Howe...
GSE121154: A myogenic double reporter human pluripotent stem cell line allows prospective isolation of skeletal muscle progenitors
Myogenic differentiation of iPSCs has been done by geneoverexpression or directed differentiation. H...
GSE138266: Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis
Cerebrospinal fluid (CSF) protects the central nervous system (CNS) and analyzing CSF aids the diagn...
GSE126002: Systematic genome perturbation reveals coordination of lipid droplets and metabolic gene regulation
Lipid droplets (LDs) store lipids for metabolic energy and are central to cellular lipid homeostasis...
GSE125130: Phytochrome-based extracellular matrix with reversibly tunable mechanical properties
Interrogation and control of cellular fate and function using optogenetics is providing revolutionar...
GSE123753: Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Rett Syndrome Neurons
Regulation of translationduring early human development is poorly understood anditsdysregulation is ...
GSE121949: RNA stability profiling in SETD2 and METTL14 knockdown HepG2 cells
To evaluate the effect of SETD2 and METTL14 on mRNA stability, we conducted RNA-seq in SETD2 or METT...
GSE124609: Cellular proteostasis collapse in mammalian senescence
Proteostasis collapse, the diminished ability to maintain protein homeostasis, has been established ...
GSE130189: Impact of DNA MMR activity on antiviral gene expression in H441 cells infected with influenza A virus
H441 cells lacking DNA MMR activity have reduced expression of antiviral and stress response genes d...
GSE157057: Human lung organoid for modeling infection and disease conditions (Lung II)
We sought to define the host immune response, a.k.a, the cytokine storm that has been implicated in ...
GSE123813: Clonal replacement of tumor-specific T cells following PD-1 blockade [single cells]
Immunotherapies that block inhibitory checkpoint receptors on T cells have transformed the clinical ...
GSE124579: RNA-seq analysis of hPSC-derived brain pericyte-like cells, hPSC-derived neural crest stem cells, and primary human brain pericytes
hPSCs were differentiated to brain pericyte-like cells through a neural crest stem cell intermediate...
GSE127831: Variable gene expression and parasite load predict treatment outcome in cutaneous leishmaniasis
Patients infected with Leishmania braziliensis develop chronic lesions that often fail to respond to...
GSE126076: RNA-sequencing of formalin fixed human primary melanoma tissue
We identify the differences in nervous system related genes and pathways inside melanoma and in the ...
GSE125186: Impaired Cell Fate by Gain-of-function Mutations in a Chromatin Reader
We previously identified the YEATS domain-containing protein ENL as a reader of histone acetylation....
GSE124720: Spliceosomal disruption of the non-canonical BAF complex in cancer
SF3B1 is the most commonly mutated RNA splicing factor in cancer, but the mechanisms by which SF3B1 ...
GSE139912: TRANSCRIPTIONAL RESPONSES IN CHILDREN WITH SICKLE CELL
To date, little is known about lung disease pathogenesis in patients with sickle cell disease (SCD)....
GSE122368: Dualism of FGF and TGFb signaling in activation of heterogeneous cancer-associated fibroblast populations converging on cancer development (RNA-Seq_FGF2)
The molecular basis for heterogeneity of cancer-associated fibroblast (CAF) populations remains to b...
GSE124620 (human): Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy
Improvements in cancer immunotherapy are needed. The immunosuppressive tumor microenvironment limits...
GSE126101: Skeletal muscle enhancer interactions identify genes controlling whole body metabolism in humans [RNA-seq]
Obesity and type 2 diabetes (T2D) are metabolic disorders influenced by lifestyle and genetic factor...
GSE126049: Phospho-small RNA-seq reveals circulating, extracellular mRNA/lncRNAs as potential biomarkers in human plasma: Healthy Cohort [HEALTHYPLASMA]
Extracellular RNAs (exRNAs) in blood and other biofluids have attracted great interest as potential ...
GSE126337: Musashi-1 is a master regulator of aberrant translation in Group 3 medulloblastoma
Transcripts regulated by Musashi-1 (MSI1) are explored through shRNA-mediated knockdown of MSI1 in S...
GSE125245: CDK7 inhibition suppresses Castration-Resistant Prostate Cancer through MED1 inactivation
We performed RNA-seq and ChIP-seq in three prostate cell lines (VCaP, LNCaP and DU145) to ascertain ...
GSE127270: Transcriptional profiling of nutrient-balanced early trilineage differentiations derived from H9 hPSCs.
Here, we show unexpected and crucial metabolic nodes through TCA flux and glutaminolysis that modula...
GSE155336: Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia [RNAseq_DACPDX]
Cancer cells display DNA hypermethylation at specific CpG islands in comparison to their normal heal...
GSE123539: Ribosomal protein RPL26 is the principal target of UFMylation
UFM1 is a small, metazoan-specific, ubiquitin-like protein modifier that is essential for embryonic ...
GSE124643: Combination Targeting of the Bromodomain and Acetyltransferase Active Site of p300/CBP [RNA-seq]
p300 and CBP are highly related histone acetyltransferase (HAT) enzymes that regulate gene expressio...
GSE124738: Transcriptomic analysis of human macrophages in 3D
Macrophages are involved in a large number of tissue functions in homeostasis and various pathologic...
GSE128101 (human): Subcellular pathways shared by afflicted patients and mutant mice identify a new drug treatment for aortic aneurysm in Marfan syndrome
We analyzed differentially expressed genes in smooth muscle cells derived from the thoracic aorta of...
GSE128097: Food-derived Compounds Apigenin and Luteolin Modulate mRNA Splicing of Introns with Weak Splice Sites
Cancer cells often exhibit extreme sensitivity to splicing inhibitors. We identified food-derived fl...
GSE124757: Phosphatase inhibitor PPP1R11 modulates resistance of human T cells towards Treg-mediated suppression of TCR signaling
We have performed RNAseq analysis of human T cells upon PPP1R11 siRNA silencing. We have explored th...
GSE129804: ETV4 is necessary for estrogen signaling and growth in endometrial cancer cells [RNA-seq]
Estrogen signaling through estrogen receptor alpha (ER) plays a major role in endometrial cancer ris...
GSE126003: IL6/STAT3 co-opts ER/FOXA1 regulatory elements to drive metastasis in breast cancer (RNA-Seq)
Interleukin 6 (IL6) signaling has been associated with an aggressive and metastatic phenotype in mul...
GSE139990: The transcriptomic differences between Th1, Tr1, and Tneg cells in controlled human malaria infection
This study was designed to determine the differences in gene transcripts between CD4+ T helper (Th)1...
GSE133898: Stem cells utilize m6A-mediated decay via YTHDF2 to regulate neural differentiation and promote pluripotency
The m6A methylation pathway has previously been shown to influence pluripotency. YTHDF2 is an RNA b...
GSE124636: IRF2BP2 Modulates the Crosstalk between Glucocorticoid and TNF Signaling
Here we have analyzed the role of interferon regulatory factor-2 binding protein-2 (IRF2BP2) in gluc...
GSE122273: Mutated H3 Histones Drive Human Pre-Leukemic Hematopoietic Stem Cell Expansion And Promote Leukemic Aggressiveness
Leukemogenesis is a stepwise progression from mutated, pre-neoplastic hematopoietic stem cells (HSCs...
GSE128201: RNA-seq analyses of human prostate cancer cells
To study the transcriptome of human prostate cancer cells, RNA-seq experiments were performed. SOURC...
GSE125403: Targeting mitochondrial structure sensitizes AML to Venetoclax
The BCL-2 family plays important roles in acute myeloid leukemia (AML) and Venetoclax, a selective B...
GSE145232: High glucose levels increase influenza-associated damage to the pulmonary epithelial-endothelial barrier
Here, the effects of high glucose levels on influenza severity were investigated using an in vitro m...
GSE123492: RNA-sequencing of highly pure synovial tissue macrophages reveals two distinct osteoarthritis subgroups that indicate different disease mechanisms.
Osteoarthritis (OA) is a leading cause of disability globally. Despite an emerging role for synovial...
GSE125222: Novel mutations segregating with Complete Androgen Insensitivity Syndrome and their molecular characteristics.
We analysed three interesting, rare cases of CAIS (Complete Androgen Insensitivity Syndrome) and rep...
GSE133822: T cell and Monocyte Specific RNAseq Analysis in Septic and Non Septic Critically-Ill Patients and in Patients with Cancer
The purpose of this study was to determine the potential differential effect of sepsis on innate ver...
GSE123860: MUC1-C represses the RASSF1A tumor suppressor and activated Kras signaling in human carcinoma cells
RASSF1A encodes a tumor suppressor that inhibits RASRAFMEKERK signaling and is one of the most frequ...
GSE122429: bulk RNA-seq of human nucleusus pulposus cell differentiations from embryonic stem cells and iPSCs
Progressive loss of nucleus pulposus cells (NPCs) is associated with the onset of intervertebral dis...
GSE130136: De-differentiation by Adenovirus E1A Due to Inactivation of Hippo Pathway Effectors YAP and TAZ [RNA-seq]
Adenovirus-transformed cells have a de-differentiated phenotype. Eliminating E1A in transformed huma...