Pluto Bio • Resources and Blog

Resources & Blog

Welcome to the Pluto Resources & Blog page, where we share the latest insights and breakthroughs in computational biology. Explore articles on the cutting-edge developments in single cell RNA-seq analysis, keep up on product updates, and explore significant research findings and industry news. Welcome to the community shaping the future of scientific discovery and collaboration, we're glad you're here!

DownloadsAugust 14, 2024

Unlocking multi-omics in drug discovery with bioinformatics

Multi-omics has emerged as a transformative technology in drug discovery. Layering genomics, transcriptomics, proteomics and other molecular analyses in a single experiment can provide deep biological insight and identify new therapeutic targets. However, developers face challenging data integration and analysis to get the most out of multi-omics data. Here, we explore how bioinformatics is key to unlocking the full potential of multi-omics and transforming drug discovery.

Case StudiesOctober 12, 2024

Nimbus Therapeutics case study

Learn how Nimbus Therapeutics is simplifying Multi-Omics Data Analysis: Nimbus Therapeutics' Success with Pluto Bio

Product UpdatesSeptember 17, 2024

Discover new targets, biomarkers, and signatures with single cell marker expression analysis

Announcing 3 new visualizations available in Pluto for analyzing single cell data! Investigate marker gene expression and signatures with ridge plots, violin plots, and UMAPs. Customize colors and layouts to make your plots truly presentation-ready 😍

Case StudiesAugust 16, 2024

Enhancing Retinal Research: Al Diri Lab's Integration of Pluto Bio

Discover how the Al Diri Lab improved efficiency and productivity in retinal research using Pluto Bio.

Case StudiesAugust 15, 2024

Leveraging Pluto Bio for Brain Drug Delivery: Wyss Institute Brain Targeting Program

The Wyss Brain Targeting Program announced it will use Pluto’s target discovery software platform to analyze and visualize -omics data, curate evidence from various published literature sources, and integrate these findings with expert insight from Wyss Institute scientists to efficiently identify and prioritize genes and proteins with transport capacity that can significantly increase drug transport into the brain.

DownloadsAugust 10, 2024

Case study: Nimbus Therapeutics - Simplifying multi-omics data analysis

Learn how Nimbus Therapeutics is simplifying multi-omics data analysis and accelerating small molecule drug discovery with Pluto’s bioinformatics platform

DownloadsAugust 1, 2024

Academic 2-pager - Translational research overview

Even for clinicians and lab members without coding experience, Pluto makes it easy for any of us to look at our own data and make publication- ready plots.

NewsJuly 23, 2024

Pluto Bio leveraged by Wyss Institute Brain Targeting Program on discovery of new transport targets for brain drug delivery

Pluto Bio partners with Wyss Institute Brain Targeting Program on novel target discovery. Leading institute to use Pluto’s target discovery platform to integrate -omics data, literature, and other evidence in their discovery of brain-targeting shuttles for drug delivery that can help revolutionize the treatment of brain diseases.

Learning SeriesJuly 2, 2024

RNA-Seq 101 for Biologists

Learn the basics of RNA-seq, including its methodology, applications, experimental design, and data analysis techniques. This 101 overview is perfect for biologists and bioinformaticists investigating transcriptomics for the first time.

NewsJune 20, 2024

Pluto selected as a winner of the 2024 Q2 Product Awards, hosted by Products that Count

Products that Count is a 501(c)3 nonprofit that helps everyone build great products. It celebrates product excellence through coveted Awards that inspire 500,000+ product managers and honor great products and the professionals responsible for their success.

NewsJune 11, 2024

Pluto featured in ColoradoBiz

ColoradoBiz profiles Pluto, a Denver start-up that helps accelerate drug development

NewsMay 29, 2024

Pluto Among Top 20 Life Sciences Companies Named to BioTools Innovator 2024 Cohort

We're thrilled to announce that Pluto has been selected as one of 20 companies in the 2024 cohort of the BioTools Innovator Accelerator, the first accelerator dedicated to supporting life science tools.

Product UpdatesMay 8, 2024

Pluto product update - Spring 2024

We've released some exciting updates in Pluto recently to help your team gain even more insight from your data. Read on for the latest

NewsMarch 12, 2024

Announcing Pluto Bio's new look

We're excited to unveil an updated brand for Pluto Bio! The new brand elevates our mission to empower every scientist to run analyses & create beautiful visualizations with modern, collaborative software.

Product UpdatesFebruary 1, 2024

Announcing end-to-end single cell RNA-seq analysis in Pluto

Ready to experience the most intuitive scRNA-seq experience yet?

Research SpotlightJanuary 31, 2024

New publication: Histone demethylase KDM5 in cardiomyocyte maturation

We’re proud to highlight a new paper citing Pluto, published in Cardiovascular Research by Dr. Priyatansh Gurha at The University of Texas Health Science Center.

Product UpdatesJanuary 17, 2024

Your home for scientific productivity: embedded apps

Increase collaboration with third-party apps in Pluto

NewsJanuary 8, 2024

JP Morgan Health Conference in San Francisco - January 2024

Pluto is excited to attend the 42nd annual JPM Healthcare Conference.

Product UpdatesNovember 30, 2023

Pluto product update

We’re excited to share a look at some of the latest product updates we’ve been working on, and give you a sneak peek into new features. Here’s the latest: Comments and Notes, Covariates, Export to Microsoft Word and Powerpoint, and more.

Learning SeriesNovember 22, 2023

The importance of considering covariates in RNA-seq and other -omics data analysis

To draw accurate and meaningful conclusions from RNA-seq data, it is essential to consider covariates, which are additional, potentially “hidden” variables that may impact gene expression in your experiment

Research SpotlightNovember 20, 2023

New publication: A human lung alveolus-on-a-chip model of acute radiation-induced lung injury

We’re proud to highlight a new paper citing Pluto, published in Nature Communications by Dr. Queeny Dasgupta at the Wyss Institute at Harvard University.

Product UpdatesOctober 22, 2023

Real-time collaboration with comments and notes

Comments and research notes allow team collaboration within Pluto

Product UpdatesOctober 9, 2023

Pluto Product Update - October 2023

New in Pluto: Graphpad Prism support, SDKs, and expanded experiments ✨

NewsOctober 3, 2023

Pluto awarded High Performer in G2 Grid Report for Pharma & Biotech - Fall 2023

The results are in for G2's Best of Pharma & Biotech software - Fall 2023

Product UpdatesJune 7, 2023

Pluto Product Update - June 2023

Check out the latest summer feature releases from Pluto! Sync your interactive analyses, visualizations and results to Benchling, create private and public share links, plus build multi-panel figures with Storyboards

NewsJune 6, 2023

Introducing the Pluto + Benchling integration

Accelerate workflows by syncing interactive Pluto visualizations to the Benchling R&D Cloud

Learning SeriesJune 2, 2023

The Origins, Comparisons, and Practical Insights into PRO-seq Technology

Dive into the world of Precision Run-On sequencing (PRO-seq) in this comprehensive blog post. Discover the origins of PRO-seq, how it compares with traditional RNA-seq, and explore a step-by-step guide on conducting a PRO-seq experiment. Uncover how this innovative technology is advancing our understanding of transcriptional dynamics and revolutionizing genomic research.

NewsMay 24, 2023

Pluto named one of the 2023 Top Vertical SaaS Companies to Watch

Pluto was named one of the 2023 Top Vertical SaaS Companies to Watch by Headline VC and Bain Capital Ventures.

NewsMay 4, 2023

Denver bioscience data software startup gets $3.7M, attention from local researchers

The company born from a Harvard research institute is ramping up its sales strategy.

NewsMay 2, 2023

Pluto announces $3.7M seed round, led by Silverton Partners

The Company’s web-based, computational biology platform empowers researchers to analyze and visualize high-dimensional biological data, and intuitively interpret and present novel findings

NewsMay 2, 2023

Pluto Biosciences Raises $3.7M to Revolutionize Biological Data Interpretation and Accelerate Life Sciences Discoveries

The Wyss Institute article on advice from Wyss lumineers to life science entrepreneurs

Learning SeriesMarch 17, 2023

Navigating RNA-Seq Data: A Comprehensive Guide to Normalization Methods

RNA sequencing (RNA-Seq) has revolutionized the way we study gene expression. The data deluge it produces, however, presents a critical question: how can we make valid comparisons between different samples or conditions?

Learning SeriesFebruary 11, 2023

Understanding Key File Formats in High-Throughput Research

Learn about key file formats in high-throughput research, including FASTQ, FASTA, BAM/SAM, BAI, SAM, VCF, GFF/GTF, BED, BedGraph, BigWig, and PDB. Discover how each format is used, what information it contains, and its significance in analyzing ChIP-seq and ATAC-seq data. Understanding these formats is crucial for efficiently handling and analyzing high-throughput data, enabling valuable biological insights and discoveries.

Product UpdatesJanuary 30, 2023

Pluto Product Update - January 2023

Check out the latest features from Pluto for 2023! Upgrade your presentation game with interactive slides and live data, get early access to the new Scientific Storyboards feature, auto-detect RNA-seq strandedness, and access over 14,000 published experiments. Plus, learn about differential expression analysis in the latest Pluto Learning Series. Join the Pluto community today!

Learning SeriesDecember 20, 2022

Accelerating Research Discovery with Bioinformatics Platforms: The Benefits of Implementation

In the field of genomics and bioinformatics, research discovery can be slowed down by the time and resources required to analyze and interpret large datasets. Bioinformatics platforms, which are specialized software or online tools that provide a range of analysis functions, can help to streamline the process and accelerate research discovery.

Product UpdatesDecember 15, 2022

Pluto Product Update - December 2022

See your end-of-year wrap-up with real-time metrics

NewsDecember 12, 2022

JP Morgan Health Conference in San Francisco - January 2023

Pluto will be participating in the upcoming 41st annual JPM Healthcare Conference.

Research SpotlightNovember 30, 2022

New publication: Stem-Cell-Derived β-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity

We’re proud to highlight a new paper citing Pluto, published today in Cells by Dr. Holger Russ’ lab at the Barbara Davis Center for Diabetes, University of Colorado School of Medicine.

Learning SeriesNovember 14, 2022

CUT&RUN 101 for Biologists

Curious about CUT&RUN and when you would use it? Learn more in this Pluto blog post about getting started with CUT&RUN.

Learning SeriesNovember 2, 2022

Exploring the Differences Between Computational Biology and Bioinformatics

This blog post explains the differences between computational biology and bioinformatics. Bioinformatics is concerned with the development and application of computational methods for analyzing and interpreting large biological datasets, while computational biology involves mathematical models and computer simulations to study complex biological systems and processes. The post also describes the different tools and platforms used in each field and how modern SaaS platforms are bringing the two fields together. Finally, a top 10 list summarizes the main differences between computational biology and bioinformatics.

NewsOctober 15, 2022

The Best Advice for Life Sciences Entrepreneurs with Pluto highlight

The Wyss Institute article on advice from Wyss lumineers to life science entrepreneurs

Learning SeriesSeptember 26, 2022

The Importance of Kaplan-Meier Curves in Computational Biology Research

Kaplan-Meier curves are an essential tool in computational biology research, allowing analysis of survival data and identification of important genes and pathways associated with specific traits or diseases. Learn more about their importance in this blog post. #computationalbiology #KaplanMeier #survivalanalysis

Learning SeriesSeptember 7, 2022

What is RSEM?

A mini intro to RSEM, a workhorse in RNA-seq data quantification.

Product UpdatesSeptember 6, 2022

Introducing an even more powerful experience for creating publication-ready plots

Pluto is revolutionizing how R&D teams think about their results and figures.

Learning SeriesJuly 26, 2022

Dimensionality Reduction Techniques in Computational Biology: Insights, origins, and Emerging Directions

Unlocking the power of big data in biology with dimensionality reduction techniques. Explore how PCA, t-SNE, and other methods are driving insights in computational biology. #DimensionalityReduction #ComputationalBiology #BigDataInsights

Learning SeriesJune 14, 2022

Visualizing Genomic Data with IGV Plots: A Powerful Tool for Genomic Research

Discover the power of Integrative Genomics Viewer (IGV) plots - a highly customizable and interactive tool for visualizing and exploring genomic data. Learn how IGV plots can be used in genomic research and the methods for creating data used in these plots. #genomics #bioinformatics.

Learning SeriesJune 1, 2022

Differential Expression Analysis: Understanding the Techniques and Benefits in Research

Differential expression analysis is a powerful tool used to identify genes or transcripts that are differentially expressed between two or more conditions or sample types. This technique is commonly used in the field of genomics, transcriptomics, and proteomics to study the molecular mechanisms underlying different biological processes, such as disease development, response to treatment, or adaptation to different environments.

Learning SeriesMay 17, 2022

Understanding Z-scores in RNA-seq Analysis

In this blog post we will explain what Z-scores are how they are calculated and how they can be used in RNA-seq analysis.

NewsMay 3, 2022

Best of Show Awards Highlights New Products in Bio-IT (Pluto featured)

The Best of Show Awards offers exhibitors at the Bio-IT World Conference & Expo an opportunity to showcase their new products.

Product UpdatesApril 27, 2022

Pluto product update - May 2022

We’re excited to share a look at some of the latest product updates we’ve been working on, and give you a sneak peek into new features. Here’s the latest: Flexible plot layouts, New analysis type: Time-to-event or survival analysis, Normalization for count data, and more.

NewsApril 27, 2022

Meet the Pluto team at Bio-IT World 2022!

The Pluto team is attending our first Bio-IT World Conference & Expo in Boston May 3-5, 2022! We’re looking forward to learning about all of the impactful research the attendees are doing, and sharing how Pluto is accelerating R&D for life sciences organizations of all sizes.

NewsApril 25, 2022

35 Most Innovative Machine Learning Startups & Companies (Denver, Colorado)

Read the Data Magazine news post which features Pluto in their article showcasing their top picks for the best Denver, Colorado based Machine Learning companies.

Learning SeriesMarch 21, 2022

Revolutionizing Gene Expression: The Power of qPCR

qPCR has transformed molecular biology by providing unparalleled accuracy and sensitivity in the detection and quantification of nucleic acid sequences. Despite its potential drawbacks, such as cost and optimization requirements, qPCR has proven invaluable in research, clinical diagnostics, and food safety testing. Recent advancements in qPCR technology, such as Digital PCR and CRISPR-based qPCR, have further expanded its applications. Learn more about the origins and potential of qPCR in our latest blog post.

Learning SeriesFebruary 21, 2022

Unraveling the Power of ChIP-seq: A Guide to Understanding Protein-DNA Interactions

ChIP-seq, or chromatin immunoprecipitation sequencing, is a powerful tool used to study protein-DNA interactions in the genome.

Learning SeriesFebruary 14, 2022

Understanding Fraction and Reads in Peaks: A Guide for ChIP-seq and ATAC-seq Analysis

We will explain what these factors are and how they are used to analyze ChIP-seq and ATAC-seq data

Research SpotlightNovember 16, 2021

November is Epilepsy awareness month: How Pluto is supporting epilepsy research

November is Epilepsy Awareness Month and organizations, researchers, journals and foundations around the world are taking this time to come together as a community and address how to best use our resources towards improving outcomes for epilepsy patients. There have been exciting advances recently in new target identification, animal research models, biomarker discoveries and stem cell therapies.

Learning SeriesNovember 3, 2021

Exploring the Power of ATAC-seq: A Guide to Understanding Chromatin Accessibility

ATAC-seq, or assay for transposase-accessible chromatin sequencing, is a powerful tool used to study the accessibility of the genome.

Learning SeriesOctober 18, 2021

DESeq2: An Overview of a Popular RNA-Seq Analysis Package

DESeq2 is a popular and widely used package in the field of bioinformatics for the analysis of RNA-Seq data. It provides a more comprehensive view of gene expression compared to traditional microarray technology.

Learning SeriesOctober 18, 2021

Unleashing the Power of Next-Generation Sequencing (NGS) with the Right Software

Next-generation sequencing (NGS) is a powerful tool used to generate high-throughput DNA sequencing data.

NewsOctober 12, 2021

Pluto Biosciences Closes $1M Seed Round for Industry-first Collaborative Life Sciences Platform

Announcing Pluto's first round of funding to fuel an industry-first collaborative platform for biological data analysis

NewsOctober 7, 2021

Wyss Institute Spinout Pluto Biosciences Bets on Collaborative Bioinformatics Platform

Read more about how Pluto Biosciences spun out of the Wyss Institute for its collaborative bioinformatics platform

Learning SeriesOctober 4, 2021

Cytokine Panels: An In-Depth Guide to Analysis and Significance

Cytokines are small proteins that play a crucial role in regulating the immune system, inflammation, and cell growth.

Research SpotlightAugust 25, 2021

Research spotlight: Novel antibody increases detection and destruction of tumors

For decades, scientists have been trying to find cures for all the various cancers that plague humanity and have made incredible strides towards this goal. We currently have various treatments that are able to significantly prolong survival and in some cases completely treat the cancerous tumor. One of the major roadblocks in our ability to cure this disease is related to the incredible heterogeneity that exists within each tumor and each patient. Additionally, the way each organism responds to the tumor cells is also extremely varied placing a lot of pressure on clinicians and scientists to constantly adapt.

NewsAugust 18, 2021

Pluto Biosciences Launches Cloud-based Collaborative Life Sciences Platform for Academia Biotech and Pharma Organizations

Press release on Pluto launching the cloud-based data management and analysis platform.

Learning SeriesAugust 17, 2021

An Introduction to SAMtools: A Powerful Tool for Analyzing Next-Generation Sequencing Data

SAMtools is a software package for interacting with and processing next-generation sequencing data

NewsAugust 17, 2021

Cloud-Based Data Management Startup Launched by Wyss Institute

Pluto, a biological data management platform stattup, was lauched from the Wyss Insitute at Harvard.

NewsAugust 16, 2021

Pluto Biosciences launches from Harvard’s Wyss Institute to speed scientific discovery

A great article by Lindsay Browne on how Pluto launched from teh Harvard's Wyss Institute to speed scientific discovery.

Research SpotlightAugust 9, 2021

Research spotlight: Modeling motor neuron diseases in vitro

Motor neurons are important cells in our body that send signals to our skeletal muscle that allow us to do activities like walk, speak, swallow, and even breathe. Motor neuron diseases like amyotrophic lateral sclerosis (ALS) destroy motor neurons. When muscles don’t receive normal signals from our motor neurons, the muscles atrophy (weaken and shrink) and we lose the ability to do those activities over time.

NewsAugust 3, 2021

Introducing Pluto

Hello world! After six foundational months of work, we are humbled and proud to announce the launch of our company: Pluto Biosciences, Inc.

Research SpotlightJuly 27, 2021

Research spotlight: COVID-19 mRNA vaccine antibody responses against new variants

How effectively do the Moderna and Pfizer mRNA vaccines mount a response against the SARS-CoV-2 variants causing new waves of infections? This study measured antibody levels in serum and found that both provided strong protection against new variants.

Learning SeriesJuly 3, 2021

Trimming RNA-seq Data: A Step-by-Step Guide

In this blog post, we will walk through the steps of trimming RNA-seq data using popular software tools such as Trimmomatic and Cutadapt.

Learning SeriesApril 22, 2021

Understanding the Role of Bioinformatics Engineers

Mastering Key Skills and Coding Languages for Effective Analysis of Biological Data: A Guide to Bioinformatics Engineering