01
Biology & Disease Discovery
8 criteriaIs the disease biology characterized well enough to anchor a program?
Disease biology at the molecular, cellular and genetic level — for example, pathway and biological program activation.
Solutions · Translational drug discovery
Structure your science around the outcomes that matter.
The criteria already exist, they're just scattered: in spreadsheets, in people's heads, in emails. Pluto gives them one home and keeps evidence aligned to them continuously.
In production at enterprise pharma
The structure
Four rings, from disease biology to mechanism.
The framework is deliberately T-shaped. Broad, consistent coverage across all four dimensions — and real depth in one, because translational risk does not distribute evenly.
The inner ring fills first, on public genetics and expression. The outer rings fill as tractability, model fidelity and mechanism come online.
Biology & Disease Discovery8
Target & Therapeutic Actionability8
Model & Disease Alignment14
Mechanistic & Functional Confidence12
The framework
42 criteria, four dimensions
Each wedge is one criterion. The four outlined wedges are open as examples: hover one to see what it measures and the evidence the program holds for it.
Biology8Target8Model14Mechanism12
In plain language
What each dimension asks.
Everything underneath it exists to answer that question with evidence, not judgment.
02
Target & Therapeutic Actionability
8 criteriaIs the target a tractable point of intervention in that biology?
Whether the target is present, accessible and specific in disease tissue — for example, target RNA expression.
03Full standard
Model & Disease Alignment
14 criteriaDoes the preclinical model recapitulate the patient biology the program depends on?
How closely the model reproduces the patient's disease biology — for example, immune context concordance.
04
Mechanistic & Functional Confidence
12 criteriaDoes perturbing the target behave the way the hypothesis predicts?
Whether perturbing the target produces the predicted effect — for example, multi-omic biomarker consistency.
The criteria themselves, the scoring rubric and the reasoning logic are held with our scientific advisory board while the framework earns the endorsement a citable standard requires.
How it works
From scattered criteria to a review-ready readout.
- 01
Start from a framework
Use the Translational Alignment Framework, a published framework such as the 5R, or the criteria your organization already applies. Every program gets the same bar.
- 02
Evidence maps as the work happens
As experiments and analyses land, results attach to the criteria they speak to. Nobody rebuilds the picture before a meeting.
- 03
Walk into every stage gate ready
Each program shows what is supported, what is partial and what is still open, with the evidence behind every call one click away.
Self-assessment
Where does your program sit against the framework?
Answer for one program and get a structured readout across all 42 criteria — coverage, conflicts, and the criteria still open.