Translational Alignment Framework
A shared definition of what counts as translatable evidence — four dimensions, 42 criteria, applied the same way to every program.
SolutionsFrameworks
Solutions · Frameworks
A framework as your program's operating structure.
Pluto is an AI harness that runs on a framework as your program's infrastructure. Here's what that looks like in practice.
Biological Fidelity Framework
Model systems assessed in step with new approach methodologies and current FDA guidance, so the evidence you generate now still counts when expectations tighten.
An AstraZeneca-inspired 5R framework
An example of a published framework running in Pluto: five dimensions — right target, right tissue, right safety, right patient, right commercial potential — modelled on the five-dimensional framework described in the literature.
Cited to the published work: Cook D, et al. Nat Rev Drug Discov. 2014;13:419–431; Morgan P, et al. Nat Rev Drug Discov. 2018;17:167–181. An illustrative example inspired by the published work — not AstraZeneca's own framework, and not affiliated with or endorsed by AstraZeneca or the authors.
Your framework, out of spreadsheets
Design a custom framework, or bring the enterprise framework you already use and get it out of spreadsheets and into the platform.
Example · An AstraZeneca-inspired 5R framework
Five dimensions, sixteen criteria, one view of the evidence.
Here is how a published framework looks once it runs in Pluto: every criterion is a wedge, filled by the evidence the program holds for it. Hover any wedge to see the criterion and its status.
The 5R framework
16 criteria, five dimensions
Hover any wedge to see the criterion it represents and the evidence currently held for it. Rings run from the right target at the centre to the right commercial potential at the edge.
Right target3
Right tissue4
Right safety4
Right patient2
Right commercial potential3
Fill depth shows evidence held per criterion. Illustrative levels. PD, pharmacodynamic; PK, pharmacokinetic.
Criteria follow the published five-dimensional framework (Cook et al., Nat Rev Drug Discov 2014; Morgan et al., 2018). Not AstraZeneca's own framework, and not affiliated with or endorsed by AstraZeneca or the authors.
Program states
Watch evidence earn its place in the framework.
Coverage isn't something that should be checked at the end; it should be continuously built. From early discovery to reverse translation, Pluto tracks the whole arc.
Stage 1 · Early discovery
Public genetics and expression evidence only. The inner ring lights up first; outer rings stay open.
9of 42
criteria evidenced
criteria evidenced
The framework
42 criteria, four dimensions
Each wedge is one criterion. The four outlined wedges are open as examples: hover one to see what it measures and the evidence the program holds for it.
Biology8Target8Model14Mechanism12
See a framework running on one of your programs.
We map the program against it and hand back the coverage, gaps included.