PLX268025

GSE126451: Transcriptomic analysis of the effect of histone H4 K31R mutation in U2OS cells

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

To explore the genome-wide gene expression changes induced by the K31R mutation in the histone H4 protein, we performed RNA-sequencing analysis in U2OS cells expressing either wildtype H4 or K31R mutant H4. We found that the lysine (K) to arginine (R) mutation mainly affected oxidative phosphorylation, mtiochondria dysfunction and et al, but not DNA damage signaling pathways. SOURCE: Zhenkun Lou (lou.zhenkun@mayo.edu) - mayo clinic

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