PLX118565

GSE124636: IRF2BP2 Modulates the Crosstalk between Glucocorticoid and TNF Signaling

• Organsim human
• Type RNASEQ
• Target gene
• Project ARCHS4

Here we have analyzed the role of interferon regulatory factor-2 binding protein-2 (IRF2BP2) in glucocorticoid and tumor necrosis factor alpha (TNF) signaling. We used ChIP-seq to analyze chromatin binding of IRF2BP2 in glucocorticoid (dexamethasone, dex) and vehicle treated HEK293 cells expressing GR (HEK293-GR). Furthermore, we used RNA-seq to analyze how silencing of IRF2BP2 modulates transcriptional responses to dex treatment in HEK293-GR cells, and dex, TNF and co-treatment (dex and TNF, DT) in A549 cells. SOURCE: Einari Niskanen (einari.niskanen@uef.fi) - Biomedicine University of Eastern Finland