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Sequencing-based assays (Page 145)
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GSE152418: Systems biological assessment of immunity to severe and mild COVID-19 infections
The recent emergence of COVID-19 presents a major global crisis. Profound knowledge gaps remain abou...
GSE149273: RV infections in asthmatics increase ACE2 expression and stimulate cytokine pathways implicated in COVID19
We present evidence that (1) viral respiratory infections are potential mechanisms of ACE2 overexpre...
GSE150962: A safe inhalational treatment prevents SARSCoV-2 viral replication in human airway epithelial cells.
Because epithelial surface pH affects airway inflammation and host defense, we study the benefit of ...
GSE150392: RNA-Seq of Human iPSC-cardiomyocytes infected with SARS-CoV-2
Coronavirus disease 2019 (COVID-19) is a viral pandemic caused by the severe acute respiratory syndr...
GSE149689: Immunophenotyping of COVID-19 and Influenza Underscores the Association of Type I IFN Response in Severe COVID-19
Although most SARS-CoV-2-infected individuals experience mild COVID-19, some patients suffer from se...
GSE148829: SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome co...
GSE151161: Blocking of the CD80/86 axis as a therapeutic approach to prevent progression to more severe forms of COVID-19
In its more severe forms, COVID-19 progresses towards an excessive immune response, leading to the s...
GSE151803: Identification of Lead Drug Candidates for COVID-19 based on Drug Screening Using Human Pluripotent Stem Cell-Derived Cells/Organoids
We systematically probed which cell types are permissive to SARS-CoV-2 infection. Transcriptomic ana...
GSE153684: SARS-CoV-2 infection and replication in human fetal and pediatric gastric organoids
Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus...
GSE151973: A gateway for SARS-CoV-2 infection in the human olfactory neuroepithelium
Various reports indicate an association between COVID-19 and anosmia, suggesting an infection of the...
GSE151879: Cardiomyocytes Infected by SARS-CoV-2 Recruit Cardiotoxic Macrophages [bulk RNA-seq dataset)
Heart injury has been reported in up to 20% of COVID-19 patients, yet the cause of myocardial histop...
GSE150819: Generation of human bronchial organoids for SARS-CoV-2 research
Coronavirus disease 2019 (COVID-19) is a disease that causes fatal disorders including severe pneumo...
GSE147507: Transcriptional response of human lung epithelial cells to SARS-CoV-2 infection
One of the greatest threats to humanity is the emergence of a pandemic virus. Among those with the ...
Vascular smooth muscle cell contractile protein expression is increased through protein kinase G-dependent and independent pathways by glucose-6-phosphate dehydrogenase inhibition and deficiency (GSE80972)
Our results suggest that the expression of VSMC contractile proteins induced by G6PD inhibition occu...
Vascular smooth muscle selective deletion of Srf (GSE138824)
We have developed a new, more VSMC selective Cre recombinase mouse that circumvents the GI phenotype...
GSE77598: Expression of MERTK based on Multiple Sclerosis (MS) risk haplotype
Whole transcriptome RNA-seq analysis to measure group-wise RNA expression level of the MERTK gene in...
GSE122353: Deficiency of Socs3 Leads to Brain-targeted EAE via Enhanced Neutrophil Activation and Production of Reactive Oxygen Species
Dysregulation of the JAK/STAT signaling pathway is associated with Multiple Sclerosis (MS) and its m...
GSE99764: CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature [2D2 T cells]
Neuroinflammatory diseases, such as multiple sclerosis, are characterized by invasion of the brain b...
GSE111972: Transcriptional profiling of human microglia reveals grey-white matter heterogeneity and multiple sclerosis-associated changes
Microglia are brain-resident, myelin-phagocytosing cells, yet their role in lesion initiation in gre...
GSE123496: Human brain tissues from healthy controls and multiple sclerosis patients
Multiple sclerosis (MS) is characterized by cell proliferation, migration and damage in various cell...
GSE79014: Sex Bias in CNS Autoimmune Disease Mediated by Androgen Control of Autoimmune Regulator
Male gender is protective against multiple sclerosis and other T cell-mediated autoimmune diseases. ...
GSE129763: Genome-wide analysis of the transcriptional profile of astrocytes during EAE in Gfap-TdTomato mice by scRNA-seq [scRNA-seq 2]
We identify astrocyte heterogeneity during EAE in B6 mice.; Multiple sclerosis (MS) is an autoimmune...
GSE66573: Defective structural RNA processing in relapsing-remitting multiple sclerosis
It is fundamentally unknown how normal cellular processes or responses to extracellular stimuli may ...
GSE66763: Functional Inflammatory Profiles Distinguish Myelin-Reactive T Cells from Patients with Multiple Sclerosis
Myelin-reactive T cells have been identified in patients with multiple sclerosis (MS) and healthy su...
GSE100297: Human optic chiasm from healthy controls and multiple sclerosis patients
Changes in gene expression that occur across the entire central nervous system (CNS) during disease ...
GSE120411: Human induced pluripotent stem cell-derived astrocytes are differentially activated by multiple sclerosis-associated cytokines
Recent studies highlighted the importance of astrocytes in neuroinflammatory diseases, interacting c...
GSE126427: Double-stranded Alu RNAs, type 1 IFN responses, and relapsing remitting multiple sclerosis
We report here an double stranded RNA sequencing from multiple sclerosis patient blood samples SOURC...
GSE130105: Genome-wide analysis of the transcriptional profile of the CNS in healthy control patients.
Multiple sclerosis (MS) is an autoimmune neurologic disease leading to demyelination and neurologic ...
GSE94730: The RNA helicase DDX39B regulates IL7R alternative splicing reducing the risk of Multiple Sclerosis
The goal of this study is to investigate the role of DDX39B in RNA splicing; Methods: RNA-Seq splici...
GSE82076: An NF-κB-dependent, lineage-specific transcriptional program regulates Treg identity and function [RNA-seq]
We found a NF-κB-dependent transcriptional program specific in Treg cells compared to Tconv cells by...
GATA1 - HUDEP-2 cells and CD34+ HSPCs treated with NT sgRNA or VHL sgRNA1
HUDEP-2 cells or CD34+ HSPCs derived erythroblast cells treated with NT sgRNA or VHL sgRNA1, and bas...
GSE66029: Functional characterization of DNA methylation in the oligodendrocyte lineage [RNASeq_development]
Myelination in the CNS is modulated by interplay between transcription factors and recruitment of ch...
GSE116242: RNA-seq of P14 mouse brain, WT and PRMT5 olig2-cre KO
Analysis of the transcriptiome of p14 mouse brains to investigate the contribution of PRMT5 in oligo...
GSE80437: RNA-sequencing of mouse knockout models for Cnp, Plp1, and Ugt8 in the frontal cortex and cerebellum
Oligodendrocytes (OLs) and myelin are critical for normal brain function and they have been implicat...
GSE82210: The lncRNA genomic landscape of oligodendrocytes reveals myelination control by a lncOL1/Suz12 complex in the CNS [RNASeq_lncOL1]
Long noncoding RNAs (lncRNAs) are emerging as important regulators of cellular functions, but their ...
GSE111704: Single cell RNA-seq from cortical cells from e16.5 HET and COP1 KO mice
This study investigates the changes in gene expression with COP1 loss. Single cell reoslution allowe...
GSE130063: Generation of induced oligodendrocyte progenitor cells from human somatic cells
The goals of this study are to compare transcriptome of NGS-derived induced oligodendrocyte progenit...
GSE94067: PRMT5-regulates developmental myelination
PRMT5 is important for gliomas, however its physiological function in oligodendrocyte progenitors (O...
GSE80439: miR-219 Cooperates with miR-338 in Myelination and Promotes Myelin Repair in the CNS
microRNAs (miRNAs) have been implicated in oligodendrogenesis and demyelinating diseases; however, i...
GSE53737: Oligodendrocyte Progenitor Cell Transcriptome in White Matter Stroke
Tissue progenitors maintain the integrity of organ systems through aging and stress. The brains whit...
GSE117997: Sequentially Acting SOX Proteins Orchestrate Astrocyte and Oligodendrocyte Specific Gene Expression
SOX transcription factors have important roles during astrocyte and oligodendrocyte development, but...
GSE123491: Gene expression profiling in the white matter with oligodendroglial stage-specfic activation or inhibition of ErbB receptors
To gain insight of how ErbB signaling in oligodendroglial progenitor cell to newly-formed oligodendr...
GSE112725: Role of fatty acid synthase in oligodendrocyte myelination
In the central nervous system, oligodendrocytes encase axons with myelin, a highly organized multila...
GSE115011: Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures
We report a method for deriving oligodendrocyte lineage cells from human pluripotent stem cells (hPS...
GSE122563: Paired Related Homeobox Protein 1 Regulates Quiescence in Human Oligodendrocyte Progenitors
Human oligodendrocyte progenitor cells (hOPCs) persist into adulthood as an abundant precursor popul...
Fungal mycobiome drives IL33 secretion and type 2 immunity in pancreatic cancer (GSE190468)
RNAseq of mouse pancreatic cancer cell lines with Kras ON vs Kras OFF.
GSE71229: Reversal of MECP2 duplication syndrome using genetic rescue and antisense oligonucleotides [Genetic Rescue Experiments]
MECP2 duplication syndrome, a childhood neurological disorder characterized by autism, intellectual ...
GSE71234: Reversal of MECP2 duplication syndrome using genetic rescue and antisense oligonucleotides [ASO time point 2]
MECP2 duplication syndrome, a childhood neurological disorder characterized by autism, intellectual ...
GSE71233: Reversal of MECP2 duplication syndrome using genetic rescue and antisense oligonucleotides [ASO time point 1]
MECP2 duplication syndrome, a childhood neurological disorder characterized by autism, intellectual ...
HEXIM1 is induced by DHODH inhibition to suppress melanoma [Gro-Seq] (GSE57430)
Our study illustrates that HEXIM1 is a tumor suppressor that responds to cell stress, consequently i...
Nucleotide stress induction of HEXIM1 suppresses melanoma by modulating cancer cell-specific gene transcription [RNA-Seq1] (GSE68039)
Our study reveals a novel role for HEXIM1 in coupling nucleotide metabolism with transcriptional reg...
Retinoic acid suppresses MYB in adenoid cystic carcinoma [RNA-seq] (GSE98007)
Our findings identify an important role of retinoic acid in MYB regulation and as a potential new ef...
Reversible mitochondrial dysfunction drives terminal T-cell exhaustion (GSE138459)
Design: RNA-sequencing of polyclonal or OT-I transgenic CD8+ T cells following acute or chronic TCR ...
GSE45732: Gene expression analysis of breast cancer cell-lines
Recurrent mutations in histone modifying enzymes in multiple cancer types imply key roles in tumorig...
GSE116817: LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state [mouse]
Deregulated activity of the LATS tumor suppressors has broad implications on cellular and tissue hom...
GSE114372: Estrogen receptor and mTOR signaling rewires cancer metabolism in obesity-associated breast cancer
Obesity is a risk factor for postmenopausal ER (+) breast cancer. Molecular mechanisms activated by ...
GSE85579: Genomic Regulation of Invasion by STAT3 in Triple Negative Breast Cancer
Breast cancer is a heterogeneous disease comprised of four molecular subtypes defined by whether the...
GSE116180: Transcriptomic but not genomic variability confers phenotype of breast cancer stem cells
Background: Breast cancer stem cells (BCSCs) are considered responsible for cancer relapse and drug-...
GSE132083: A transcriptome dataset revealing the molecular features of breast cancer stem cells
Triple negative breast cancers lack targeted therapies with little side effects and contain higher p...
GSE126268: Transcriptional signatures derived from murine tumor-associated macrophages predict outcome in breast cancer patients
Macrophages are frequently the most abundant immune cells in murine and human cancers. Studies in va...
GSE139274: Identification of differentially expressed lncRNAs and mRNAs in luminal-B breast cancer by RNA-sequencing
Background: Luminal B cancers show much worse outcomes compared to luminal A. This present study aim...
GSE60182: Integrative transcriptome-wide analyses reveal critical HER2-regulated mRNAs and lincRNAs in HER2+ breast cancer
Breast cancer is a major health problem affecting millions of women worldwide. Over 200,000 new case...
GSE116816: LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state [human]
Deregulated activity of the LATS tumor suppressors has broad implications on cellular and tissue hom...
GSE52194: mRNA-sequencing of breast cancer subtypes and normal tissue
Goal: To define the digital transcriptome of three breast cancer subtypes (TNBC, Non-TNBC, and HER2-...
GSE106638: RNA-Seq analysis to identify novel genes associated with Neuropilin-1 expression in the BT-474 breast cancer cell model
Background: Neuropilin-1 (NRP-1) is a non-tyrosine kinase glycoprotein receptor that elicits multipl...
GSE111073: Expression profiling by RNA-Seq of breast cancer samples from patients in walnut-consuming and control groups
Consumption of walnuts has slowed breast cancer growth and/or reduced the risk of breast cancer in m...
GSE87080: Transcriptional signature of lymphoblastoid cell lines of BRCA1, BRCA2 and non-BRCA1/2 high risk breast cancer families
Approximately 25% of hereditary breast cancer cases associated with a strong familial history can be...
GSE120796: Next-generation RNA sequencing to determine changes in gene expression during breast cancer progression
Purpose: The goal of the study is to compare NGS-derived transcriptome in an isogenic breast cancer ...
GSE119937: Molecular Determinants of Post-Mastectomy Breast Cancer Recurrence
Breast cancer (BC) adjuvant therapy after mastectomy in the setting of 1-3 positive lymph nodes has ...
GSE126894: A TFAP2C Gene Signature is Predictive of Outcome in HER2 Breast Cancer (RNA-Seq)
Abstract: A subset of HER2 breast cancers with amplification of the TFAP2C gene locus becomes addict...
GSE136673: Regulation of DNA Methylation at Enhancers by TET2 Finetunes Gene Transcription in ER-Positive Breast Cancer Cells
Background: Aberrant DNA methylation is an epigenetic hallmark of most malignant tumors including br...
GSE89857: Global gene expression profile of primary mouse lung and small cell lung cancer (SCLC) tissues
Mouse SCLCs were induced by lentiviral vector expressing luciferase-Mycl-shp53-shRb or IkBaM-Mycl-sh...
GSE95536: Expression of TGF-inducible myosin-X predicts survival and chemotherapy resistance in squamous cell lung cancer
Squamous cell lung carcinoma (SCC) corresponds to about 25% of all lung cancers. Therapeutic approac...
GSE60052: The RNAseq of 79 small cell lung cancer (sclc) and 7 normal control
Even though small cell lung cancer (SCLC) has entered the age of broad genomic analysis, platinum-ba...
GSE109629: RNA and miRNA sequencing of an IGF1R transgenic mouse model of lung cancer
RNA and miRNA sequencing of lung tumors induced by transgenic overexpression of the type-I insulin l...
GSE59831: Transcriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq
We sequenced mRNA from individual stormal cells (Macrophages, Monocytes, and Neutrophils) and tumor ...
GSE93302: In vivo CRISPR screening unveils multiple epigenetic regulators as novel tumour suppressor genes in lung cancer
This study provides the first systematic CRIPSR screening of tumour suppressor genes (TSGs) in vivo ...
GSE99531: A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small cell lung cancer treated with PD-1 blockade
Evidence from mouse chronic viral infection models suggests that CD8+ T cell subsets characterized b...
GSE76033: Expression Profiling of Macrophages Reveals Multiple Populations with Distinct Biological Roles in an Immunocompetent Orthotopic Model of Lung Cancer
Macrophages represent an important component of the tumor microenvironment and play a complex role i...
GSE128478: Identification of miR181ab1 targets in mutant Kras lung cancer cells
RNAseq comparison of miR181ab1-knockout and miR181ab1-reconstituted mouse lung cancer cells (KLA) SO...
GSE125000: Encapsulated miR-200c and Nkx2.1 in a nuclear/mitochondria transcriptional regulatory network of non-metastatic and metastatic lung cancer cells
Background: MicroRNAs are noncoding RNA molecules of ~22 nucleotides with diagnostic and therapeutic...
GSE51144: Characterization of the genetic mouse model of non-small cells lung cancer p53R172Hg/KrasG12D
Background: Non-small cell lung cancer (NSCLC) accounts for 81% of all cases of lung cancer and they...
GSE100412: Transcriptional signatures associated with in vivo growth of lung cancer cells
Interactions between cancer cells and the host cells in the tumor microenvironment (TME) are critica...
GSE70046: Oncogenic deregulation of EZH2 as an opportunity for targeted therapy in lung cancer [RNA-Seq]
As a master regulator of chromatin structure and function, the EZH2 lysine methyltransferase orchest...
GSE69770: Tobacco smoke-inducible enhancers linked to xenobiotic response genes and lung carcinogenesis identified through analysis of lung tissue epigenomes
Smoking-associated DNA hypomethylation has been observed in blood cells and was recently linked to l...
GSE108500: Knockdown of FOXP1 promotes the development of lung adenocarcinoma
Lung cancer is one of the most common cancers in the world, which accounts for about 27% of all canc...
GSE106899: Multi-Omic Molecular Profiling of Lung Cancer Risk in Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a known risk factor for developing lung cancer sugge...
GSE119004: Establishment and disease modeling of non-small cell lung cancer organoids
Purpose: The goal of this study is to establish and molecularly characterize non-small cell lung can...
GSE81089: Next Generation Sequencing (RNAseq) of non-small cell lung cancer
Cancer testis antigens (CTAs) are of clinical interest as biomarkers and present valuable targets fo...
GSE63356: Integrative genome-wide analysis in non-small cell lung cancer cells
We used complementing high-throughput sequencing technologies, including RNA-seq, DNase I-seq, and C...
GSE129221: Apatinib preferentially inhibits Gefitinib-resistant lung cancer cells by inducing cell cycle arrest and inhibiting VEGFR signaling pathway
Targeted therapy for patients with EGFR mutations by tyrosine kinase inhibitors (TKIs) has provided ...
Effect of WDR5 degrader on H3K4me2 in human cancer cell lines
Examination of the genome-wide binding of H3K4me2 in MV4;11 and MIA PaCa-2 cells after compound trea...
MV4;11 cells post-treatment with either DMSO, OICR-942, MS67, or MS67N (GSE150554)
Examination of transcriptome profiles in MV4;11 cells post-treatment with either DMSO, OICR-9429 (a ...
MIA PaCA-2 cells treated with DMSO, OICR-9429, MS67, MS67N, or after shRNA induction (GSE150554)
Examination of transcriptome profiles in MIA PaCA-2 cells post-treatment with either DMSO, OICR-9429...
MV4;11 cells after induction of expression of the WDR5-targeted shRNA to induce WDR5 knockdown (KD), relative to empty vector mock (shEV) (GSE150554)
Examination of transcriptome profiles in MV4;11 cells after induction of expression of the WDR5-targ...