PLX282950

GSE149273: RV infections in asthmatics increase ACE2 expression and stimulate cytokine pathways implicated in COVID19

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project COVID-19 transcriptomics

We present evidence that (1) viral respiratory infections are potential mechanisms of ACE2 overexpression in patients with asthma and (2) ACE activation regulates multiple cytokine anti-viral responses that could explain a mechanism for cytokine surge and associated tissue damage. These results suggest that the recent finding of severe COVID-19 in asthma patients with recent exacerbations may be attributable to synergistic biomolecular interactions with viral co-infections. SOURCE: Eugene,H,Chang (echang@email.arizona.edu) - Eugene Lab The University of Arizona

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