PLX123790

MIA PaCA-2 cells treated with DMSO, OICR-9429, MS67, MS67N, or after shRNA induction (GSE150554)

Organsim human
Type RNASEQ
Target transcript
Project A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models (GSE150555)

Examination of transcriptome profiles in MIA PaCA-2 cells post-treatment with either DMSO, OICR-9429 (a small molecule designed to interfere with WDR5 binding to MLL), MS67 (a WDR5-specific PROTAC/degrader), MS67N (a MS67 analog control incapable of E3 ligand conjugation), or after induction of expression of the WDR5-targeted shRNA to induce WDR5 knockdown (KD), relative to empty vector mock (shEV).

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