PLX294031

GSE93302: In vivo CRISPR screening unveils multiple epigenetic regulators as novel tumour suppressor genes in lung cancer

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project Lung Cancer Transcriptomics

This study provides the first systematic CRIPSR screening of tumour suppressor genes (TSGs) in vivo and identifies bona fide TSGs especially for epigenetic regulators contributing to lung tumour progression. Moreover, our data provides a potential therapeutic strategy for the effective treatment of UTX-mutant lung tumours. SOURCE: Hongbin Ji (hbji@sibcb.ac.cn) - Shanghai Institute of Biochemistry and Cell Biology

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