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Sequencing-based assays (Page 116)
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GSE143619: Hydrogen sulfide dysregulates the immune response by suppressing central carbon metabolism to promote tuberculosis
The ubiquitous gasotransmitter hydrogen sulfide (H2S) has been recognised to play a crucial role in ...
GSE140807: Dissecting the early steps of MLL induced leukaemogenic transformation using a new mouse model of AML
Leukaemogenic mutations commonly disrupt cellular differentiation and/or enhance proliferation, thus...
GSE153718: Next Generation Sequencing (RNA sequencing) of Wild Type and GLI1 knock-out CUTLL1 childhood T lymphoblastic lymphoma cell line
T-cell acute lymphoblastic leukemia (T-ALL) is a highly malignant pediatric leukemia, where few ther...
GSE152757: Febrile temperature change modulates CD4 T cell differentiation via a TRPV channel-regulated Notch-dependent pathway
Here we report the transcriptomic differences between ex vivo CD4+ T cells (nave CD4+ T Cells), CD4+...
GSE151957: Expression profile of the 22Rv1 cells overexpressing ABHD5
ABHD5 is a crucial metabolic regulator of cancer cells. The goal of this study is to identify the re...
GSE135114: Gene expression profiles of TEL-AML1 acute lymphoblastic leukaemia blasts retrieved from central nervous system and spleen
Purpose: To investigate metabolic adaptation of leukaemia in two different microenvironments: centra...
GSE140764: Light effect via Opn3 on the activity of brown adipocytes
Opsin3 (Opn3) is a transmembrane heptahelical G-protein-coupled receptor (GPCR) with the potential t...
GSE152374: Therapeutic reprogramming of the intestinal stem cell state via Hippo signaling [Organoid_RNAseq]
While the Hippo transcriptional coactivator YAP is considered oncogenic in many tissues, its roles i...
GSE155562: Next Generation Sequencing Facilitates Quantitative Analysis of wild type, Twist1+/- and Twist1+/- with suture regeneration surgery mice
Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular path...
GSE145310: RNA expression of reactivated Antigen-specific memory CD4 T cells previously exposed to tolerogenic or immunogenic stimulation
Activated and memory CD4 T cells play important roles in many autoimmune diseases often acting as up...
GSE143643: HDAC3 IS AN EPIGENETIC INHIBITOR OF THE CYTOTOXICITY PROGRAM IN CD8 T CELLS [RNA-seq]
Cytotoxic T cells play a key role in adaptive immunity by killing infected or cancerous cells. While...
GSE155572: Tanshinone I inhibit normal and malignant hematopoiesis by repressing EZH2 activity [human]
Purpose: To explore the mechanism of how Tan I inhibits malignant hematopoiesis at the gene expressi...
GSE145130: Next Generation Sequencing Facilitates Quantitative Analysis of the lncRNA Transcriptome in 6 Distinct Germ Cell Types During Mouse Spermatogenesis
Purpose: The goals of this study are to obtain the lncRNA landscape in 6 distinct germ cell types du...
GSE149248: Partial inhibition of mitochondrial complex I attenuates neurodegeneration and restores energy homeostasis and synaptic function in a symptomatic Alzheimers mouse model
We performed next-generation RNA sequencing (RNA-seq) using brain tissue from 23 months old non-tran...
GSE152731: RNA sequencing discerns sub-populations of pancreatic -cells and dynamics of gene expression in partial pancreatectomy model
We employed single-cell RNA sequencing of islets in young mice subjected to partial pancreatectomy (...
GSE144317: Identification of a Cxcl10+ monocyte subset with a pathogenic signature in the CNS during auto-immune neuroinflammation
Multiple Sclerosis (MS) is characterized by pathological inflammation resulting from recruitment of ...
GSE149251: Next Generation Sequencing Facilitates Quantitative Analysis of MV4-11 cell line Transcriptomes
Purpose: The goals of this study are to compare side population and main population cells transcrip...
GSE145047: Linking Phospho-Gonadotropin Regulated Testicular Helicase (GRTH/DDX25) to Histone Ubiquitination and Acetylation Essential for Spermatid Development During Spermiogenesis
In this study, we examined genome-wide transcriptome profiles of germ cells isolated from GRTH Knock...
GSE144277: Functional genomic consequences of MBD5 knockdown in mouse brain and CRISPR-derived neurons [mouse]
Background: MBD5, encoding the methyl-CpG-binding domain 5 protein, has been proposed as a necessary...
GSE144313: RNA-seq and Ribo-seq of WT and METTL5 KO mECS.
Covalent chemical modifications of cellular RNAs directly impact all biological processes. However, ...
GSE142208: Chd8 haploinsufficiency impairs early brain development and impacts protein homeostasis later in life
Chromodomain helicase DNA-binding protein 8 (CHD8), now considered a master transcriptional regulato...
GSE149272: Elevated NSD3 Histone Methylation Activity Drives Squamous Cell Lung Cancer
Amplification of chromosomal region 8p11-12 is a frequent genetic alteration implicated in the etiol...
GSE143711: A hotspot mutation p.L162R in IKZF3 drives leukemogenesis via transcriptional dysregulation
IKZF3 encodes an IKAROS Family transcription factor and has been recently identified as a novel muta...
GSE152393: Next Generation Sequencing Facilitates Quantitative Analysis of WT and Il2ra mut/mut memory OT-I cell transcriptomes
Cognate antigen signals control CD8+ T cell priming, expansion size and effector versus memory cell ...
GSE152904: FcRIIB engagement drives agonistic activity of Fc-engineered OX40 antibody to stimulate human tumor-infiltrating T cells
Background: OX40 (CD134) is a co-stimulatory molecule of the tumor necrosis factor receptor (TNFR) s...
GSE147747: Molecular Atlas of the Adult Mouse Brain
Brain maps are essential for integrating information and interpreting the structure-function relatio...
GSE147781: Comparison of mRNA profiles of AGO2 sufficent and deficient pancreatic tissue in the LSL KRASG12D mouse model of pancreatic cancer
Purpose: The goals of this study are to compare NGS-derived transcripts to compare the expression o...
GSE155782: A3shNT cell transcriptomics
Altered oncogene expression in cancer cells causes loss of redox homeostasis resulting inoxidative D...
GSE152944: Transcriptional Changes during T cell development following conditional loss of Bcl6
In this study we investigated the changes during T cell development in Rag knockout Bcl6 conditional...
GSE142361: Transcriptomic and Functional Studies Reveal Undermined Chemotactic and Angiostimulatory Properties of Aged Microglia During Stroke Recovery
Age-dependent alterations in microglia behavior have been implicated in neurodegeneration and CNS in...
GSE144312: KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease
Kallikrein-related peptidase 6 (KLK6) is a secreted serine protease hypothesized to promote inflamma...
GSE147092: Parallel social information processing circuits are differentially impacted in autism
Parallel processing circuits are thought to dramatically expand the network capabilities of the nerv...
GSE144295: Osteomodulin and proline/arginine-rich end leucine rich repeat protein contribute to bladder cancer initiation and progression by controling transition between epithelial and mesenchymal cells through regulation of TGF-b and EGF pathways
Two secreted proteins, osteomodulin (OMD) and proline/arginine-rich end leucine repeat protein (PREL...
GSE147095: mTORC1 and B cell survival signal regulate formation of memory precursors in the germinal center [2]
A still unanswered question is what drives the small fraction of activated germinal center (GC) B ce...
GSE142267: Novel Alzheimer risk genes determine the microglia response to amyloid- but not to TAU pathology
Polygenic risk scores have identified that genetic variants without genome-wide significance still a...
GSE153941: Dynamic IFN signalling underlies treatment response to immune checkpoint therapy in cancer [bulk RNA-seq]
The on/off dynamics of IFN signalling underlie the therapeutic response to immune checkpoint therapy...
GSE148723: The chromatin landscape of primary synovial sarcoma organoids is linked to specific epigenetic mechanisms and dependencies [RNA-seq]
Synovial sarcoma (SyS) is an aggressive mesenchymal malignancy invariably associated with the chromo...
GSE148732: Differential gene expression in mACVR1 NS v wt-ACVR1 NS.
To study the effect of the ACVR1 G328V mutation in tumor neurospheres with a background of NRASV12 o...
GSE153983: Bulk mRNA sequencing of wildtype (WT) and mutator mouse embryonic fibroblasts (MEFs)
The proteasome is the main proteolytic system for targeted protein degradation in the cell. Its func...
GSE145147: A role of the CTCF binding site at enhancer Ea in Tcra rearrangement
We found that the CTCF binding site (named as EACBE) at the enhancer E of Tcra is essential for norm...
GSE153770: Distinct waves from the hemogenic endothelium give rise to layered Lymphoid Tissue Inducer cell ontogeny [scRNA-seq]
LTi cells are part of the ILC family and essential for the formation of secondary lymph nodes within...
GSE147064: MacroH2A deletion causes neuronal developmental deficits and autism-like behavior in mice
Purpose:To further understand how MacroH2A regulates the proliferation of neural progenitor cells, R...
GSE154786: RNA-sequencing analysis identifies BRLF1-dependent viral and cellular transcriptome during EBV primary infection in B lymphoma cells
Purpose: Immediate-early protein BRLF1 plays an important role in lytic infection of Epstein-Barr vi...
GSE147144: GDE2-dependent activation of canonical Wnt signaling in neurons regulates oligodendrocyte maturation
Neurons and oligodendrocytes communicate to regulate oligodendrocyte development and ensure appropri...
GSE78025: Acute exposure to graded levels of hypoxia in U87-MG cells: the role of hypoxia in GBM
Purpose: Hypoxia is a predominant feature in GBM and its microenvironment. It is associated with the...
GSE143672: Transcriptomic and metabolomic profiling of long-lived growth hormone releasing hormone knock-out mice: Evidence for altered mitochondrial function and amino acid metabolism
Numerous genetic manipulations that extend lifespan in mice have been discovered over the past two d...
GSE152786: Single-cell RNA transcriptomics of thymic iNKT cells from C57BL/6 and Hivep3-/- mice
Single-cell RNA-seq analysis of murine thymic iNKT cells from two independent C57BL/6 mice and two i...
GSE155970: Transcriptome sequencing Data sets for human epithelial cells response during Francisella Tularensis infection.
The goal of this study is to determine the host response of human epithelial cells during infection ...
GSE153646: Fibroblasts direct differentiation of human breast epithelial progenitors
Background: Breast cancer arises within specific regions in the human breast referred to as the term...
GSE143606: Critical Regulation of a NDIME/Mef2c Axis in Embryonic Stem Cell Neural Differentiation and Autism
Recent studies revealed that microdeletion of human chromosome 5q14.3 leads to the occurrence of neu...
GSE144346: The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programmes
Covalent chemical modifications of cellular RNAs directly impact all biological processes. However, ...
GSE156065: Bromodomain 4 inhibition leads to MYCN downregulation in Wilms tumor cells
We have undertaken a functional genomics approach to uncover novel therapeutic strategies efficaciou...
GSE147081: Single Cell RNA-Seq of CD8+ T cell subsets responding to tumor
Tissue-resident memory CD8+ T cells (Trm) provide host protection through continuous surveillance of...
GSE155956: PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance
We report that PD-1 restraint of regulatory T cell suppressive activity via the PI3K-AKT pathway and...
GSE153722: Identification and Characterization of N6-Methyladenosine CircRNAs and Methyltransferases in the Lens Epithelium Cells from Age-related Cataract
To explore the involvement of N6-methyladenosine (m6A) modification in circular RNAs (circRNAs) and ...
GSE153976: Differential glia activation in early epileptogenesis - insights from cell-specific analysis of DNA methylation and gene expression in the contralateral hippocampus
Morphological changes in mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (mTLE-HS) are well...
GSE144586: Alternative enhancer usage and targeted Polycomb marking hallmark promoter choice during T cell differentiation
To characterize the regulatory landscape of developing T-cells, we performed a wide epigenetic and t...
GSE153645: Soy protein nanofiber scaffolds for uniform maturation of hiPSC-derived retinal pigment epithelium
Retinal pigment epithelial cells differentiated from human induced pluripotent stem cells (hiPSCs), ...
GSE156044: Transcriptomics analysis of mesenteric adipose tissue from Crohn's disease patients and healthy controls [RNA-seq]
A feature of Crohn's disease is the extra-intestinal manifestation of creeping fat, defined as expan...
GSE152615: RNAseq from human islets treated with brefeldin A as a model of Golgi stress
Type 1 diabetes (T1D) is characterized by immune mediated destruction of insulin producing cells. B...
GSE144342: Thymic resilience and T cell output require Liver X Receptors
The thymus is a primary lymphoid organ necessary for optimal T cell development. Here we show that l...
GSE143696: Mutant p53 regulates survivin to foster lung metastasis
Esophageal cancer is one of the most common cancers where TP53 is mutated frequently. Esophageal squ...
GSE153988: Prdm16 deficiency leads to age-dependent cardiac hypertrophy, adverse remodeling, mitochondrial dysfunction, and heart failure
Hypertrophic cardiomyopathy (HCM) is one of the most frequent inherited heart condition and a well-e...
GSE151092: Perivascular Mesenchymal Cells Control Adipose Tissue Macrophage Accrual in Obesity
Chronic low-grade visceral white adipose tissue (WAT) inflammation is a hallmark of metabolic syndro...
GSE145474: RNA-seq on periodontal tisuues of susceptible and resistant collaborative cross mice after periodontal infection
We assessed alveolar bone changes of Collaborative cross (CC) lines in response to a mixed oral infe...
GSE152811: RNA-seq for DIMT1 wild-type and E85A mutant overexpression in DIMT1 heterozygous knockout HEK cells
Dimethyladenosine transferase 1 (DIMT1), an 18S rRNA N6,6-dimethyladenosine (m26,6A) methyltransfera...
GSE147519: Transcriptome signature of miRNA-26b KO mouse model suggests novel transcriptional interactions
miR26b KO mice were generated by Laser assisted (XY-Clone Hamilton Thorne) injection of R1/E(129/Sv)...
GSE144838: Whole transcriptome analysis of mouse aortas and kidneys with or without deletion of the EGFR in vascular smooth muscle cells after 18 weeks of high fat diet
Obesity causes diabetes type 2 (DMT2) leading to vascular dysfunction and finally renal end-organ da...
GSE149243: Increased processing of SINE B2 non coding RNAs unveils a novel type of transcriptome de-regulation underlying amyloid beta neuro-pathology
More than 97% of the mammalian genome is non-protein coding, and repetitive elements account for mor...
GSE151275: Gene expression profiling in neuronal cells identifies a different type of transcriptome modulated by NF-Y
We knocked down NF-Y in two types of neuronal cells, neuro2a neuroblastoma cells and sorted brain st...
GSE149811: Estrogen signaling modulates the colon microenvironment during obesity
Epidemiological studies highlight a strong association between obesity and colorectal cancer (CRC). ...
GSE155898: LARP7, a new ROS sensor, protects against heart failure by enhancing mitochondrial biogenesis
LARP7 controls the SIRT1 activity and homeostasis, which is essential for mitochondrial biogenesis, ...
GSE146740: Single cell RNA-seq (smartseq2) analysis of the ETP population from E15.5 embryonic thymus of the 5x polychromILC mice
ILC2 contribute to immune homeostasis, protective immunity and tissue repair. However, an understan...
GSE152841: KLRG1+ Memory CD8 T cells Combine Properties of Short-lived Effectors and Long-lived Memory
CD8 effector T cells with a CD127hi KLRG1- phenotype are considered precursors to the long-lived mem...
GSE155973: Macrophage-derived thrombospondin1 promotes obesity-associated non-alcoholic fatty liver disease
Thrombospondin 1 (TSP1) is a multifunctional matricellular protein. Previously we have shown that TS...
GSE153772: Characterization of novel zinc finger protein ZNF414 DNA binding and gene regulatory activity by integrative analysis of ChIP-exo, ATAC-seq and RNA-seq data (RNA-seq)
Transcription factor binding to DNA is a central mechanism regulating cellular gene expression. Thus...
GSE151410: Phenotypic and Gene Expression Features Associated with Variation in Chronic Ethanol Consumption in Heterogeneous Stock Collaborative Cross Mice
Of the more than 100 studies that have examined some aspect of the relationships between excessive e...
GSE145713: Exceptionally high recirculation of peripheral T regulatory cells to the NOD thymus strongly inhibits de novo development of their precursors
Regulatory T lymphocytes (Treg) play a vital role in the protection of the organism against autoimmu...
GSE75990: Specification and Diversification of Pericytes and Smooth Muscle Cells from Mesenchymoangioblasts
Recently, we identified mesenchymoangioblast (MAB), as a clonal mesodermal precursor for mesenchymal...
GSE152913: Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition [RNA-seq]
Type 2 cytokine responses promote parasitic immunity and initiate tissue repair but, can also result...
GSE147056: Loss of the neural-specific BAF subunit ACTL6B relieves repression of early response genes and causes recessive autism
Synaptic activity in neurons leads to the rapid activation of genes involved in mammalian behavior. ...
GSE149825: Therapeutic decoupling of MHC-I and PD-L1 expression increases the efficacy of immune checkpoint blockade (SMAC_RNAseq)
Immune checkpoint blockade (ICB) therapy has revolutionized the treatment of multiple cancers, but t...
GSE151453: Sialyl-Lewis-X Glyco-antigen Is Enriched on Cells with Persistent HIV Transcription During Therapy
A comprehensive understanding of the phenotype of persistent HIV-infected cells, both transcriptiona...
GSE149761: Gene expression profiling in murine mononuclear phagocyte lineage cells
To understand the mechanism underlying monocyte and dendritic cell development through the regulatio...
GSE156255: miR-22 promotes stem cell traits via activating WNT/-catenin signaling in cSCC
Purpose: Next-generation sequencing (NGS) has revolutionized system-based cell pathway analysis. The...
GSE146728: TAK-418-418, a LSD1 inhibitor, can rescue the genome wide chromatin abnormality in hippocapmus tissue in KMT2D+/bGeo mice after 2 week treatment [RNA-seq]
Mutation in KMT2D, a histone-lysine N-methyl transferase, is responsible for majority of Kabuki synd...
GSE142508: Mediator MED23 induces premature senescence by interacting with BCLAF1 via blocking autophagy flux in lung cancer cells
macroautophagy/autophagy plays a key role in regulating the balance between cell survival and senesc...
GSE155955: Lipid remodeling in response to methionine stress in MDA-MBA-468 triple-negative breast cancer cells
Methionine is an essential amino acid and critical precursor to the cellular methyl donor S-adenosyl...
GSE142541: Redefining the heterogeneity of peripheral nerve cells in health and autoimmunity
Peripheral nerves contain axons and their enwrapping glia cells named Schwann cells (SC) that are ei...
GSE142546: Morphological PV types display unique transcriptional signatures and an age-dependent onset of hemoglobin gene expression
The diversity created by >100 different neural cell types fundamentally contributes to brain functio...
GSE153663: Next Generation Sequencing of Wild Type and Zeb1-/- HSCs
Zeb1, a zinc finger E-box binding homeobox epithelial-mesenchymal (EMT) transcription factor, confer...
GSE147936: PROM1(CD133)-dependent expressed genes from mouse embryonic DRG neurons
Prom1, also knwon as CD133 is a stem cell marker that are down-regulated during developmental proces...
GSE155987: Effects of LMTK2 knockdown on total RNA expression in CFBE41o- cells after TGF1 or vehicle control (HCl+BSA) treatment
The purpose of this study was to increase the current knowledge about the LMTK2 network and its inte...
GSE142571: Illumina 3'UTR biased-sequencing of total homogenate from mPFC and CeA of mice following chronic intermittent ethanol exposure and microglia depletion
Purpose: Alcohol dependence results in microglia proliferation in brain and changes in microglia mor...
GSE83781: Propargite, an environmental chemical, interactswith GWAS identified diabetes genes to impact human pancreatic -cell death [PTPN2 knockout]
This paper describes the first time a high-content environmental chemicals screen using pancreatic -...
GSE79833: CRIG identifies a novel population of highly phagocytic peritoneal macrophages associated with disease severity in patients with cirrhosis and ascites
Infections are an important cause of morbidity and mortality in patients with decompensated cirrhosi...
GSE78522: Next Generation Sequencing for Quantitative Analysis of transcriptome of follicular compared to non-follicular CD8 T cells from HIV+ Lymph nodes
The goal of the study was to characterize the molecular signatures of CD8 T cell subpopulations sort...
GSE151452: RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels
The eukaryotic RNA exosome is a ubiquitously expressed complex of nine core proteins (EXOSC1-9) and ...
GSE144722: Transcriptomic analysis of thymic epithelial cells and extra thymic epithelial cells
Regulation of MHC I expression has been studied almost exclusively in hematolymphoid cells. We repor...
GSE144690: Loss of Fbxw7 triggers mammary tumorigenesis associated with E2F/c-Myc activation and Trp53 mutation
Fbw7 is a tumor suppressor protein that regulates the degradation of a multitude of oncogenic substr...