PLX236945
GSE75990: Specification and Diversification of Pericytes and Smooth Muscle Cells from Mesenchymoangioblasts
- Organsim human
- Type RNASEQ
- Target gene
- Project ARCHS4
Recently, we identified mesenchymoangioblast (MAB), as a clonal mesodermal precursor for mesenchymal and endothelial cells. Here we show, that MABs have the capacity to produce mesenchymal progenitors, which can be differentiated into pericytes or smooth muscles cells under the influence of PDGF-BB or TGF plus sphingosylphosphorylcholine (SPC), respectively. Based on these studies we established the hierarchy of vasculogenic progenitors that provides the platform for interrogation of molecular mechanisms regulating vasculogenic cell specification and diversification from primitive posterior mesoderm. SOURCE: Oleg Moskvin University of Wisconsin-Madison
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