PLX078672

GSE145713: Exceptionally high recirculation of peripheral T regulatory cells to the NOD thymus strongly inhibits de novo development of their precursors

• Organsim mouse
• Type RNASEQ
• Target gene
• Project ARCHS4

Regulatory T lymphocytes (Treg) play a vital role in the protection of the organism against autoimmune pathology. It is therefore paradoxical that relatively large numbers of Treg were found in the thymus of type I diabetes-prone NOD mice. However, we now know that the Treg population in the thymus is composed of newly developing cells and cells that had recirculated from the periphery back to the thymus. Recirculating Treg inhibit the development of their precursors. We here show that exceptionally large numbers of Treg develop in the thymus of young NOD mice. However, once emigrated from the thymus, an unusually large proportion of these cells is activated in the periphery and recirculates back to the thymus. These recirculating Treg then strongly inhibit development of their precursors, which thus reaches levels comparable to those found in most other strains. Thus, a particularly dynamic mechanism quantitatively regulates development of Treg in the NOD thymus. SOURCE: Joost van Meerwijk (Joost.van-Meerwijk@inserm.fr) - Joost van Meerwijk Eq1 INSERM