PLX067820

GSE145147: A role of the CTCF binding site at enhancer Ea in Tcra rearrangement

Organsim mouse
Type RNASEQ
Target gene
Project ARCHS4

We found that the CTCF binding site (named as EACBE) at the enhancer E of Tcra is essential for normal Tcra rearrangement.The EACBE deletion impaired the TAD structure of the 3 region of the Tcra/d locus and the interactions between the proximal V genes and the J genes without changing the accessibility of the J array. SOURCE: Hao bingtao (haobingtao@gmail.com) - Southern Medical University

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