PLX311396

GSE156065: Bromodomain 4 inhibition leads to MYCN downregulation in Wilms tumor cells

Organsim human
Type RNASEQ
Target gene
Project ARCHS4

We have undertaken a functional genomics approach to uncover novel therapeutic strategies efficacious for those patients with anaplastic Wilms tumor. Genomic analysis, in vitro chemical screens and microfluidic experiments demonstrate that MYCN over-expression in Wilms tumor can be modulated via BRD4 inhibition resulting in a reduction in Wilms tumor cell growth. SOURCE: Charles Keller (charles@cc-tdi.org) - cc-TDI

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