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Sequencing-based assays (Page 39)
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GSE75919: Skeletal-muscle specifc Gprc6a-/- mice.
Gprc6a|Mck-/- (Gcrp6a skeletal muscle specific knockout)(n=4) are compared to Gprc6afl/fl (WT) mice ...
GSE68799: RNASeq identified human transcriptome alterations in Chinese Nasopharyngeal Carcinoma
Our study is the first transcriptome profiling of Chinese NPC patients. These results provide both m...
GSE74290: Heterogeneity in early lymphoid compartments [RNA-Seq]
In order to understand the developmental trajectories of early lymphocyte development it is crucial ...
GSE73176: Mdm2 enhances stemness-promoting chromatin modifications through the Polycomb Repressor Complex 2 in a p53-Independent Manner [RNA-Seq]
The Mdm2 oncoprotein ubiquitinates and antagonizes p53 but may also carry out p53-independent functi...
GSE74855: Transcriptional effects of I-PpoI induced DNA double strand breaks in mouse lymphocytes
DNA double-strand breaks (DSBs) and their repair can cause extensive epigenetic changes. As a result...
GSE108341: ICAMs are not obligatory for functional immune synapses between nave CD4 T cells and lymph node DCs
The quantitative deep bulk MARS-seq analysis demonstrated that DCs from ICAM-1/2 double knockout (DK...
GSE75931: A spatio-temporal characterization of the transcriptional landscape of epidermal development
The mouse epidermis develops from a single layer of cells at e9.5 to a fully formed organ at birth c...
GSE84734: The chromatin associated proteins HP1 behave as liver specific tumour suppressors in mice
Purpose : In this study we observed that inactivation of the genes encoding for the chromatin associ...
GSE75453: RNA-Seq to compare gene expression to MIRTA tiling arrays
We performed additional sequencing of samples from GSM718982, GSM718983 to increase coverage in orde...
GSE74737: Gene Networks and Blood Biomarkers of Methamphetamine-Associated Psychosis: A Preliminary Integrative RNA-Sequencing Report
The clinical presentation, course and treatment of methamphetamine-associated psychosis (MAP) are si...
GSE74518: Adult-induced cardiac-specific knockout of Parkin provokes minimal transcriptional effect
Adult mice bearing homozygous floxed Parkin alleles (PMIDs 15249681, 21376232; TM Dawon), with or wi...
GSE97041: Epigenetically repressing human cytomegalovirus lytic infection and reactivation from latency in THP-1 model by targeting H3K9 and H3K27 histone demethylases
Human Cytomegalovirus (hCMV) infects a broad range of the population and establishes life-long laten...
GSE75665: A strong relatedness between interleukin-10 and acute mountain sickness revealed by transcriptome analysis
Acute mountain sickness (AMS), which may progress to life-threatening high altitude cerebral edema, ...
GSE77857: BACH2 regulates CD8+ T cell differentiation by controlling access of AP-1 factors to enhancers
T cell antigen receptor (TCR) signaling drives distinct responses depending upon the differentiation...
GSE86442: Investigating the role of retinol dehydrogenase 10 in the retina visual cycle
Rapid pigment regeneration is critical for the continuous function of cone photoreceptors in bright ...
GSE76356: DICER controls macrophage polarization and tumor response to immunotherapy
Tumor-associated macrophages (TAMs) have immunosuppressive capacity in mouse models of cancer. Here ...
GSE135318: DOT1L-mediated Murine Neuronal Differentiation associates with H3K79me2 Accumulation and preserves SOX2-Enhancer Accessibility
To study whether acute inhibition of DOT1L induces global chromatin states alterations, we profile a...
GSE140849: Long-term absence of Langerhans cells alters the gene expression 2 profile of keratinocytes and dendritic epidermal T cells
In this study, with the help of RNA-sequencing, we show for the first time that long-term absence of...
GSE140277: Loss of epigenetic modifications on the inactive X chromosome and sex-biased gene expression profiles in B cells from NZB/W F1 mice with lupus-like disease
We report loss of epigentic silencing marks on the inactive X on female mice with lupus like disease...
GSE137537: Single-cell Transcriptomic Atlas of the Human Retina Identifies Cell Types Associated with Age-Related Macular Degeneration [Microfluidics]
Here we perform massively parallel single-cell RNA sequencing (scRNA-seq) of human retinas using two...
GSE81252: Multilineage communication regulates human liver bud self-organization from pluripotency
Conventional 2-D differentiation from pluripotency fails to recapitulate cell interactions occurring...
GSE75484: Effect of PD-1 immune checkpoint in Alzheimer's disease transgenic mice
We examined the brain's choroid plexus and myeloid cell populations isolated from the brain of 5XFAD...
GSE80587: High-dose maternal folic acid (FA) supplementation before conception impairs reversal learning in offspring mice
Here, we address whether maternal dietary supplementation at 40 mg/kg chow (FD), restricted to a per...
GSE75889: The LIM homeodomain transcription factor Lhx2 is required for Mller glia development in the vertebrate retina.
Purpose: Mller glia are the only glial cell type produced by the neuroepithelial progenitor cells wh...
GSE75706: RNA Sequencing Facilitates Quantitative Analysis of Primary Microglia Transcriptomes
Using RNA-seq, we report here that primary microglia (PM) cells have a distinct transcriptomic signa...
GSE138841: VAMP8 contributes to TRIM6-mediated type-I interferon antiviral response upon West Nile virus (WNV) infection
Purpose: Several members of the tripartite motif (TRIM) family of E3 ubiquitin ligases regulate immu...
GSE121445: Profiling of circular RNAs in gastric cancer tissues and adjacent normal tissues
Purpose: To investigate the role and mechanism of circRNAs in gastric cancer.; Methods: RNA-seq of r...
GSE126131: Distinct fibroblast states drive clinical outcomes in ovarian cancer and are regulated by TCF21
Recent studies indicate that cancer-associated fibroblasts (CAFs) are phenotypically and functionall...
GSE77751: Glioblastoma multiforme cancer stem cells from different patients exhibit consistent gene expression and mechanical phenotypes across distinct states in culture
Cancer stem cells are responsible for the regenerative properties of tumors, manifested as recurrenc...
GSE103736: Transcriptional profile of brown adipose tissue (BAT) and white vastus lateralis (WV) from BATI4KO mice
We report RNA-seq data from the brown fat and vastus muscles of mice lacking IRF4 in brown fat (BATI...
GSE126209: Gene expression profiling in Osteosarcomas
To explore whether KSHV infection is a risk factor for osteosarcoma development in ethnic Uyghur pop...
GSE81555: Determination of Lsd1 function in brown adipose tissue by global transcriptome analysis [RNA-seq]
To investigate the role of Lsd1 in BAT, we crossed mice harboring conditional Lsd1 alleles (Zhu et a...
GSE77185: AML1/ETO accelerates cell migration and impairs cell-to-cell adhesion and homing of hematopoietic stem/progenitor cells
The AML1/ETO fusion protein found in acute myeloid leukemias functions as a transcriptional regulato...
GSE149030: Id1 and Id3 Maintain Steady State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration
Single cell RNA-Seq was performed on ID1 ID3 null endothelial cells to determine the effects of ID g...
GSE79663: TCF4 regulatory gene networks in developing dorsal telencephalon
Haplo-insufficiency of TCF4 induced by mutations or microdeletion of TCF4 gene causes Pitt-Hopkins D...
GSE77894: RNA-SEQ E18.5 Ret-positive (EGFP-labeled) Nav1.8 dorsal root ganglia neurons.
The goal of this set is to build expression data using FACS isolated Ret-positiveNaV1.8 cells harves...
GSE148205: Memory like NK cells display stem cell like properties after Zika virus Infection
Here we show that Zika virus infection induces memory like NK cells that express CD27. This subset s...
GSE70486: p53 coordinates Wnt and TGF- inputs on mesendoderm differentiation genes
The TGF- superfamily member Nodal triggers mesendoderm differentiation in embryonic stem (ES) cells....
GSE123506: Identification of Lenalidomide resistance pathways in Myeloma and targeted re-sensitization using Cereblon replacement, inhibition of STAT3 or targeting of IRF4
In the present study, we established four lenalidomide resistant HMCLs by culturing IMiD responsive ...
GSE77740: Single Novel single cell assay reveals progressive lymphoid defect in aging multipotent hematopoietic progenitors cell RNA-seq reveals LMPP clonal dynamics in aging.
Declining immune function with age is associated with reduced lymphoid output of hematopoietic stem ...
GSE75659 (mouse): Dissecting the clonal nature of allelic expression in somatic cells by single-cell RNA-seq
Cellular heterogeneity can emerge from the expression of only one parental allele, however it has re...
GSE129251: RNA sequencing analysis of ex vivo expanded CD27+CD70- and CD27-CD70+ human regulatory T cells
Our study shows that after extended stimulation of human CD4+CD25+CD127- Tregs in vitro, a stable ce...
GSE70819: Spatially distinct neutrophil responses within the inflammatory lesions of pneumonic plague
During pneumonic plague, the bacterium Yersinia pestis elicits the development of inflammatory lung ...
GSE125206: RNAseq analysis of BRCA deficient tumors treated with saline, Nano-Talazoparib or Talazoparib
We report the gene expression profile in BRCA deficient tumors after treatment with saline, nanopart...
GSE76222: Multiphasic and dynamic changes in alternative splicing during induction of pluripotency are coordinated by numerous RNA binding proteins [ESRP DKO]
Alternative splicing (AS) plays a critical role in cell fate transitions, development and disease. R...
GSE76288: Impact of miRNA Levels, Target-Site Complementarity and Cooperativity on ceRNA-Regulated Gene Expression
Expression changes of competitive endogenous RNAs (ceRNAs) have been proposed to influence microRNA ...
GSE145219: The effect of CDK6 expression on the murine transcriptome
We performed RNA-seq analyses in BCR-ABL+ cells either expressing or lacking CDK6. 3 replicates per ...
GSE75524: Activation of the IGF1 pathway mediates changes in cellular contractility and motility in single-suture craniosynostosis
We examined the effect pg IGF1 actibation on cellular contractility and migration in SSC osteoblast ...
GSE75715: TAp73 is a master regulator of airway multiciliogenesis [RNA-Seq]
Comparative RNA seq analysis of WT and global p73KO Mouse Tracheal Epithelial Cell (MTECs) during t...
GSE124876 (human): Transcriptomic analysis of primary human T cells and murine RAW 264.7 macrophages 3D cultured in different collagen densities
The density of the extracellular matrix has a dramatic impact on the gene expression profile of T ce...
GSE76217: RNA-SEQ on resting (R) and stimulated (S) B cells from several IgH 3'RR mutant models
We evaluated by RNA-seq obveral transcripts in B cells (resting and activated for 2 days with LPS) s...
GSE76294: Next generation sequencing analysis of epididymal adipose tissue (II)
We analyze the contribution of alternative splicing to the transcriptional complexity in adipose tis...
GSE140068: Chromatin-associated RNA of HSV-1 infected primary human fibroblasts including infection with vhs mutants
Primary human foreskin fibroblasts (HFF) were infected with wild-type herpes simplex virus 1 (HSV-1)...
GSE76878: INTS8 mutations cause severe neurodevelopmental syndrome
Integrator (INT) is an RNA polymerase II (RNAPII)-associated complex that was recently identified to...
GSE77179: Transcriptional changes in breast cancer cell lines associated with vascular mimicry
The goal of this study was to determine the transcriptional changes associated with breast cancer ce...
GSE113675 (mouse): Simultaneous multiplexed amplicon sequencing and transcriptome profiling in single cells
We developed a tunable ligation technology to alter beads used for to capture mRNA for single-cell R...
GSE73823: Genetic code expansion in stable cell lines enables encoded chromatin modification
Genetically encoded unnatural amino acids provide powerful strategies for modulating the molecular ...
GSE70520: Dysregulated TLR7 signaling drives anemia via development of hemophagocytic macrophages
The debilitating autoimmune disease Systemic Lupus Erythematosus (SLE) is closely associated with To...
GSE76303: Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl
We analysed the effect on the genomic localisation of cohesin (Stag1 and Scc1) and CTCF in CTCF, Smc...
GSE77219: RNA Sequencing Reveals Immunosuppressive Role of Anthrax Lethal Toxin in Human Lung Epithelial and Monocytic Cells
Using RNA-seq, we report here that anthrax lethal toxin (LeTx) induces immunosuppression in human lu...
GSE70816: Reprogramming roadblocks are system-dependent
Since the first generation of induced Pluripotent Stem cells (iPSCs), several reprogramming systems ...
GSE75049: Exploiting single-cell expression to characterize co-expression replicability
We sequenced two types of interneurons from adult mouse frontal cortex across multiple library batch...
GSE75944: Gene expression changes in dorsal dermal fibroblasts after beta-catenin deletion in vivo
Goal of this study was to examine gene expression changes upon conditional deletion of beta-catenin ...
GSE76316: Transcriptomic signatures uncover gene expression differences associated with the development of phenotypic differences in serial organs
Gene expression differences during development provide the basis for adult phenotypic differences. T...
GSE88996: Peripheral self-reactivity regulates antigen-specific CD8 T cell responses and cell division under physiological conditions
It is unknown how nave CD8 T cells that harbour different and distinct T cell receptors to the same ...
GSE138910: RNA expression in WT and Dot1L KO CD8 T cell subsets
We studied the role of the histone methyltransferase DOT1L in T cell development and differentiation...
GSE99786: Bulk and single-cell RNA-seq of mouse blastocyst, blastoid Trophoblast stem cells and Embryonic stem cells
We did bulk and single cell RNA sequencing of blastocysts, blastoids, trophoblast stem cells (TSC) a...
GSE139178: RNA-seq of prostate cancer cell lines with acquired resistance to AKT inhibitors GDC-0068 (ATP competitive) or MK206 (allosteric)
Goal: Study resistance mechanisms to ATP-competitive vs. allosteric AKT inhibitors, in prostate canc...
GSE70813: Hobit and Blimp1 instruct a universal transcriptional program of tissue-residency in lymphocytes
Tissue-resident memory T cells (Trm) are non-circulating memory T cells that localize to portals of ...
GSE125867: Transcriptome of liver tissue at ZT01, ZT05, ZT09, ZT13, ZT17 and ZT21
Our study looks at the liver circadian transcriptome. SOURCE: Andrés HidalgoImaging of the Cardiovas...
GSE77214: Adipose Angiotensin AT2 Receptors Modulate Thermogenesis
The brain renin-angiotensin system (RAS) stimulates resting metabolic rate in part through a mechani...
GSE76514 (human): Laser-capture microscopy coupled with Smart-seq2 (LCM-seq) for robust and efficient transcriptomic profiling of mouse and human tissues
Generally, when LCM is used in diverse transcriptomic analyses, several hundred, if not thousands, o...
GSE74798: Tumor-Specific Retrogene NANOGP8 Reprograms Prostate Cancer Cells to Castration Resistance by Engaging the FOXA1/AR Signaling Axis and MYC [RNA-seq]
Targeted disruption of the embryonic stem cell (ESC) self-renewal and pluripotency factor NANOG dimi...
GSE75976: Ikaros-regulated genes in a mouse model of BCR-ABL1+ acute lymphoblastic leukemia
To examine Ikaros tumor suppressor mechanisms, we have utilized inducible RNAi to dynamically restor...
GSE76315: Pax6 links H3K4 methylase activity to transcriptional regulation of Plekha1 through its distal enhancer
We performed ChIP-seq on mouse lens epithelial cells (TN4) and mouse newborn lens. Genome-wide bindi...
GSE138913: RNASeq of differentiated and undifferentiated BLaER1 cells
We generated RNASeq data to investigate the expression levels of RNases in differentiated and undiff...
GSE71877: The mir-143-145 cluster plays a pro-tumorigenic role in lung adenocarcinoma by promoting neoangiogenesis
A growing body of literature has proposed cell-autonomous tumor suppressor functions for the mir-143...
GSE107821: Transcriptomes of human monocytes after ex vivo exposure to uric acid
Innate immune memory, also refered to as trained immunity (TRIM) is the phenomenon whereby innate im...
GSE76118: Transcriptomic profiling maps anatomically patterned subpopulations among single embryonic cardiac cells [RNA-seq]
Embryonic gene expression intricately reflects anatomical context, developmental stage, and cell typ...
GSE76317: Next generation sequencing analysis of epididymal adipose tissue (III)
We analyze the contribution of alternative splicing to the transcriptional complexity in adipose tis...
GSE79758: Differential gene expression in intestinal mouse crypts after loss of KLF5
To determine potential targets of KLF5 we performed RNA-sequencing on jejunal crypts isolated from K...
GSE74029: Tetra-Pt(bpy) Inhibits Homologue Recombination-Mediated Telomere Elongation in human ALT cancer cells
The RNA-seq results reveal Tetra-Pt(bpy) has no effect on gene expression. SOURCE: Yong Zhao (zhaoy8...
GSE76095: CFTR is a tumor suppressor gene in murine and human intestinal cancer [RNA-seq]
Analysis of the cystic fibrosis gene Cftr in the colon and small intestine of Cftr-deficient murine ...
GSE76367: METTL3 promotes translation in human cancer cells
we find METTL3 associates with polyribosomes and promotes translation. METTL3 depletion inhibits tra...
GSE76747: The Histone Methyltransferases MLL1 and DOT1L Cooperate with Meningioma-1 to Induce AML [Human RNA-seq]
Purpose: To characterize transcriptional changes associated with inhibition of Dot1l in 2 inv(16) pa...
GSE101528: Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer
The Ras-family small GTPase RAB25 is involved in numerous aspects of endosomal protein trafficking a...
GSE99915: Single-cell mapping of lineage and identity in direct reprogramming
Direct lineage reprogramming involves the remarkable conversion of cellular identity. Single-cell te...
GSE77256: RNA-seq analysis of hair follicle stem cell transcriptome upon loss of the transcription factor FOXC1
We report downstream gene expression changes in stem cells of the adult mouse hair follicle upon con...
GSE100071: Tet2 loss dysregulates the behavior of bone marrow derived mesenchymal stromal cells [RNA-seq]
Bone marrowderived mesenchymal stem/progenitor cell mRNA profiles of WT and Tet2/ mice were generat...
GSE70713: Single-cell analysis reveals lineage segregation and pluripotency state transition in early post-implantation mouse embryos
Here we report the transcriptome data of 236 single cells freshly isolated from mouse embryos on day...
GSE77243: Sensory experience restricts cortical plasticity by inducing IGF-1 in VIP neurons
RNA-seq libraries purified from the visual cortices of neurons expressing Emx-, GAD2-, PV-, SST-, or...
GSE108593: Hyaluronic Acid Synthase-2 (HAS2) overexpression and deficiency effect on hepatic stellate cells
Analysis of hepatic stellate cells (HSCs) isoltaed from ASMA-HAS2 transgenic and HSC-specific Has2 k...
GSE126850: Disparate anticancer activity of structurally similar multi-kinase inhibitors through cumulative differential effects on individual targets
Despite recent improvements many cancer patients do not respond to immune or targeted drugs and requ...
GSE73986: An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell
Toxoplasma gondii is an obligate intracellular Apicomplexan parasite capable of invading and survivi...
GSE75130: Characterization of macrophage - cancer cell crosstalk in estrogen receptor positive and triple-negative breast cancer
We performed whole transcriptome sequencing of human monocytes that were co-cultured with estrogen r...
GSE77261: Genome-wide expression change by SHARPIN knockdown in MCF-7 cells
We aim to investigate the role of SHARPIN in breast cancer progression. MCF-7 cells were used as the...
GSE76926: RNA-seq transcriptonal profiling in partial hepatectomy liver tissues in Arid1a WT and liver specific KO mice.
Arid1a is the subunit of SWI/SNF complex, which was reported to guide SWI/SNF to DNA. Here, we found...
GSE75909: miR-23~27~24 clusters control effector T cell differentiation and function
Coordinated repression of gene expression by evolutionarily conserved microRNA (miRNA) clusters and ...
GSE124664: Identification of altered developmental pathways in human juvenile HD iPSC with 71Q and 109Q using transcriptome profiling
Purpose: In Huntington disease (HD) subtle symptoms in patients may occur years or even decades prio...
GSE79020: Extensive cryptic splicing upon loss of RBM17 and TDP43 in neurodegeneration models
Translating ribosome affinity purification technology was used to isolate mRNAs from cerebellar Purk...