PLX277663

GSE76367: METTL3 promotes translation in human cancer cells

Organsim human
Type RNASEQ
Target gene
Project ARCHS4

we find METTL3 associates with polyribosomes and promotes translation. METTL3 depletion inhibits translation, and both wild-type and catalytically inactive METTL3 promote translation when tethered to the 3' untranslated region (UTR) of a reporter mRNA. Mechanistically, METTL3 enhances mRNA translation through an interaction with the translation initiation machinery. SOURCE: Peng Du (Peng.Du@childrens.harvard.edu) - Richard Gregory Boston Children’s Hospital, Harvard Medical School

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