PLX115497

GSE77214: Adipose Angiotensin AT2 Receptors Modulate Thermogenesis

• Organsim mouse
• Type RNASEQ
• Target gene
• Project ARCHS4

The brain renin-angiotensin system (RAS) stimulates resting metabolic rate in part through a mechanism involving suppression of the circulating RAS. This effect appears to be mediated through a reduction in angiotensin AT2 receptor (AT2R) signaling within inguinal fat. To examine the molecular mechanisms underlying this effect, mice with hyperactivity of the brain RAS (sRA mice, expressing human renin via the synapsin promoter and human angiotensinogen via its own promoter) and littermate controls were chronically infused with vehicle or the AT2R specific agonist, CGP-42112a (CGP, 90 ng/hr, 8 wk, sc). To identify altered signaling pathways, total RNA was isolated from inguinal adipose tissue and transcript abundance was quantitated by RNA-Seq. SOURCE: Henry Keen (henry-keen@uiowa.edu) - Dr. Curt D. Sigmund's Laboratory University of Iowa