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Sequencing-based assays (Page 38)
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GSE113298: Characterizing the transcriptomic profile of the cortex within the long-term window of ischemic tolerance mediated by resveratrol preconditioning
To identify novel genes and adaptations induced by resveratrol preconditioning that could promote lo...
GSE148389: MiR-1253 exerts tumor-suppressive effects in medulloblastoma via inhibition of CDK6 and CD276 (B7-H3) (RNA-seq dataset)
Of the four primary subgroups of medulloblastoma, the most frequent cytogenetic abnormality, i17q, d...
GSE75297: DIGIT regulates endoderm differentiation of human embryonic stem cells
Endoderm differentiation is a critical step leading to development of the gastrointestinal system. ...
GSE143485: nsp1 acts on HEK-293T
Idenrify the function of NSP1 SOURCE: Zhou Shen (szhou1314@webmail.hzau.edu.cn) - Huazhong agricult...
GSE69968: RNA-Sequencing of primary myoblasts from mice with a satellite cell specific knockout of the histone demthylase UTX/KDM6A
The KDM6 histone demethylases (UTX/KDM6A and JMJD3/KDM6B) mediate removal of repressive histone H3K2...
GSE98577: RNA sequencing of WT and Hmgb2-/- mice liver treated with CCL4
loss of Hmgb2 in vivo in mouse liver largely prevented CCl4-induced liver fibrosis. The goal of the ...
GSE76097: In vivo analysis of astrocyte ribosome-associated mRNA after traumatic spinal cord injury
Analysis of gene expression by astrocytes or non-astrocyte cells in spinal cord injury (SCI) lesions...
GSE76138: Transcriptional profiling of Regulatory T-cells isolated from adult skin and skin draining lymph nodes (SDLNs)
Purpose: The goals of this study were to identify preferential gene expression signatures that are u...
GSE74442: Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms
Histiocytic neoplasms are clonal, hematopoietic disorders characterized by an accumulation of abnorm...
GSE68511: Context- and cell-type specific function of miR155-Socs1 interaction in immune regulation
The microRNA (miRNA) dependent regulation of gene expression confers robustness to cellular phenotyp...
GSE69162: MLL4 prepares the enhancer landscape for FoxP3 induction via chromatin looping
MLL4 is an essential subunit of the H3K4 methylation complexes. We report that Mll4 deficiency compr...
GSE76122: Transcriptomic analysis of human neural progenitor cells differentiation into astrocytes
In this study we isolated and cultured neural progenitor cells (NPCs) from human fetal brain collect...
GSE120284: The transcriptional fingerprint of satellite glial cells changes over time following peripheral nerve injury
For the first time, we here characterize the transcriptional signature of satellite glial cells (SGC...
GSE68509: Akt1/Protein Kinase B Enhances Transcriptional Reprogramming of Fibroblasts to Functional Cardiomyocytes
Conversion of fibroblasts to functional cardiomyocytes represents a potential approach for restoring...
GSE125914: Calcineurin promotes myogenic gene expression
We identified four major temporal patterns of Calcineurin (Cn)-dependent gene expression in differen...
GSE74201: Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in a Human Neural Stem Cell Model of Huntingtons Disease
We have utilized induced pluripotent stem cells (iPSCs) derived from Huntingtons disease patients (H...
GSE73127: Global gene expression profile of primary mouse brain and glioblastoma tissues
Mouse glioblastomas were induced by lentiviral vector expressing HrasG12V and shRNA against p53. Tum...
GSE74371: GATA-1 and heme regulate the erythroid cell transcriptome.
Alas2 gene encodes the rate-limiting enzyme in heme biosynthesis. CRISPR/Cas9-mediated ablation of t...
GSE72855: Intragenic DNA methylation prevents cryptic transcription initiations on gene bodies [RNA-seq]
In mammals, DNA methylation occurs mainly at 5mC of CpG dinucleotides. The methylation on the promot...
GSE72857: Transcriptional heterogeneity and lineage commitment in myeloid progenitors [single cell RNA-seq]
Within the bone marrow, hematopoietic stem cells differentiate and give rise to diverse blood cell t...
GSE74251: RNA-seq of YB5 and MCF7 treated with different doses of decitabine
RNA-seq was performed after YB5 cells were treated with 1uM decitabine, and MCF7 cells were treated ...
GSE73502: Widespread shortening of 3 untranslated regions and increased exon inclusion characterize the human macrophage response to infection [mRNA]
Changes in gene regulation have long been known to play important roles in both innate and adaptive ...
GSE123740: SUM52PE treated with PI3K-mTOR inhibitors
PI3K/mTOR inhibition alters gene transcription signatures involved in metabolism and cell cycle cont...
GSE78147: Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type Young and Old muscle Transcriptomes
Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular path...
GSE74215: Transcriptome analysis of HSV-1 infected dorsal root ganglia and large intestinal musculara
Following genital HSV-1 infection in mice, virus spreads to and infects the sensory neurons of the d...
GSE74322: Global gene expression differences between blood- and lymphatic-specific human dermal microvascular endothelial cells
We performed high throughput RNA-sequencing on blood and lymphatic HMVECs to identify differences in...
GSE74263: Characterization of a novel mutation in O-GlcNAc transferase that segregates with disease in a family with X-linked intellectual disability
An X-chromosome exome sequencing analysis identified a mutation in O-GlcNAc transferase (OGT) (pL254...
GSE140714: Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis [hADSCs]
We implemented transcriptomic analyses of hADSCs treated with metformin 6 days SOURCE: Hailiang Liu ...
GSE74344: Oocyte-expressed Yes-associated Protein (YAP) is a Key Activator of the Early Zygotic Genome in Mouse
We generated maternal and paternal mouse models with Yap1-deletion, and elucidated the function of m...
GSE128054: MYT1 attenuates neuroblastoma cell differentiation by inhibiting retinoic acid signaling pathway
This study first reveals that MYT1 is a potential oncogene in neuroblastoma, which is significantly ...
GSE71916: Gene expression profiling of neurons with Rbfox1 and Rbfox3 knockdown and rescue with cytoplasmic or nuclear Rbfox1 isoform [RNA-seq]
Human genetic studies have identified the neuronal RNA binding protein, Rbfox1, as a candidate gene ...
GSE136053: Comparative Analysis of the Transcriptome of Latent Autoimmune Diabetes (LADA) Patients from Eastern China
We did the transcriptome analysis of peripheral blood mononuclear cells of LADA patients and healthy...
GSE68958: RUNX1B expression distinguishes megakaryocytic and erythroid lineage fate in adult hematopoiesis
The Core Binding Factor (CBF) protein RUNX1 is a master regulator of definitive hematopoiesis, cruci...
GSE121999: Genome-wide expression analysis of EPCAM+ epithelial cells from 3-dimensional lung organoids harboring Hermansky-Pudlak Syndrome-associated mutations
Introduction of Hermansky-Pudlak Syndrome-associated mutations with CRISPR/Cas9 genome editing, allo...
GSE76865: Independent roles of switching and hypermutation in the development and persistence of B lymphocyte memory [Nurr77]
Somatic hypermutation (SHM) and class switch recombination (CSR) increase the affinity and diversify...
GSE122742: Bulk RNA sequencing of intracortically-projecting neurons at P10
Distinct subtypes of intracortically-projecting neurons (ICPN) are present in all layers, allowing p...
GSE68915: mRNA Sequencing of skeletal muscle genes in wildtype and BCATm (BCAT2) KO mice
Consumption of a protein containing meal by a fasted animal promotes protein accretion in skeletal m...
GSE73468: Transcriptome profiling in knock-in mouse models of Huntington's disease [cerebellum_mRNA]
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that is characterized ...
GSE124704: Supraphysiological testosterone impedes ARv7 and DNA repair program in preclinical models of enzalutamide-resistant prostate cancer
The study aims to determine SPT effect on the CRPC growth and molecular alterations using LuCaP PDX ...
GSE73771: EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent
In proliferating cells, where most Polycomb repressive complex 2 (PRC2) studies have been performed,...
GSE72501: Ro60-knockout cells
RNA-seq of Ro60-null GM12878 cell lines in order to determine the gene expression changes resulting ...
GSE98413: Role of JunB in Th17 cell effector stability [RNA-seq]
Here we identify the activator protein-1 (AP-1) factor JunB as an essential regulator of Th17 cell i...
GSE121448: Eumyc and WT NK cells
Eumyc lymphoma was inoculated i.v. into C57BL/6J mice. Spleens were harvested from healthy or Emyc l...
GSE73813: Spatial interplay between Polycomb and Trithorax complexes controls transcriptional activity in T lymphocytes [RNA-Seq]
Trithorax group (TrxG) and Polycomb group (PcG) proteins are two mutually antagonistic chromatin mod...
GSE110524: Metformin reverses a precancerous niche featuring cytoplasmic p21WAF1/CIP1-expressing hepatocytes and prevents hepatocellular carcinoma development
Prevention and treatment options for hepatocellular carcinoma (HCC) are presently limited, underscor...
GSE73532: YY1 plays an essential role at all stages of B cell differentiation [RNA-seq]
YY1 is a ubiquitously expressed transcription factor that has been demonstrated to be essential for ...
GSE146077: Peripherally-induced brain tissue resident memory CD8 T cells [RNA-seq]
OT-I CD8 T cell transcriptome of cells isolated from Spleen, IV+ brain, and IV- brain of DCLM immuni...
GSE72368: Gene expression profiling from cohesin knockdown cells obtained grown in methylcellulose
We performed RNA-sequencing in c-Kit+ cells that were infected with retroviruses expressing shRNAs f...
GSE76870: A forward genetic screen for modifiers of transgene silencing in the mouse identifies Inhibitor of Growth Family Member 5 (Ing5)
Here we report the identification of a mutant allele of the Ing5 gene, also known as Inhibitor of Gr...
GSE121964: Diverse Long RNAs Are Differentially Sorted into Extracellular Vesicles Secreted by Colorectal Cancer Cells
Long RNA-seq analysis on cellular and extracellular samples from a KRAS mutant colorectal cancer cel...
GSE74920: Transcriptome Analysis of Developing Intestine [RNA-Seq]
Background: The muscularis externa (ME) of the adult intestine consists of two layers of visceral sm...
GSE79111: Gene expression profile in IM-0223 cells transfected with KPC1 or control vector using RNA-seq
Melanoma is a highly aggressive cancer with increasing incidence rates and a poor survival, particul...
GSE114013: Identifying the molecular mode of action of itraconazole in colorectal cancer
Two cell lines (HT55 and SW948) were found responsive to itraconazole treatment. To identify the mo...
GSE105827: Common lymphoid progenitor derivation of plasmacytoid dendritic cells is mediated by Bcl11a
Plasmacytoid dendritic cells (pDC) specialize in type I interferon production to coordinate innate a...
GSE75659 (human): Dissecting the clonal nature of allelic expression in somatic cells by single-cell RNA-seq
Cellular heterogeneity can emerge from the expression of only one parental allele, however it has re...
GSE69170: 1,25-Dihydroxyvitamin D3 Controls a Cohort of Vitamin D Receptor Target Genes in the Proximal Intestine That Is Enriched for Calcium Regulating Components (RNA-seq)
1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) plays an integral role in calcium homeostasis in higher organ...
GSE76203: Integrative genomics identifies the molecular basis of resistance to Azacytidine therapy in Myelodysplastic Syndromes
RNA-seq of bone marrow CD34+ cells of myelodysplastic syndrome (MDS) and chronic myelomonocytic leuk...
GSE77695: Developmental Acquisition of Regulomes Underlies Innate Lymphoid Cell Functionality
Innate lymphoid cells (ILCs) play key roles in host defense, barrier integrity, and homeostasis, an...
GSE107791: Mononuclear phagocytes locally specify and adapt their phenotype in the inflamed central nervous system, peak of disease expression data
We introduce an in vivo imaging approach that allows us to temporally and spatially resolve the evol...
GSE75386: Single cell RNAseq of electrophysiologically characterized neurons of the hippocampus
Recent advances in single-cell RNAseq technologies are enabling new cell type classifications. For n...
GSE73559: Gene expression analysis to identify Klf2 target genes in B-cell progenitors [+Klf2]
The sequential activation of distinct developmental gene networks governs the ultimate identity of a...
GSE74729: A novel RAF kinase inhibitor with DFG-out binding mode: high efficacy in BRAF-mutant tumor xenograft models in the absence of normal tissue hyperproliferation
Purpose: Seek for differential gene expression in vemurafenib-resistant A375 tumors vs. untreated co...
GSE146073: Transcriptome of ZFP36L1-sufficient and ZFP36L1-deficient Fo B cells
High-throughput sequencing analysis of transcriptome from LPS-activated B cells from Lymph node of Z...
GSE79169: Determine the function of lncBATE10 in brown and white adipocyte culture
Purpose: Determine the function of lncBATE10 in brown and white adipocyte differentiation; Methods: ...
GSE68155: Investigating GPR34 expression regulation using whole transcriptome sequencing of spleens and dendritic cells from wildtype and GPR34 knockout mice
Naive spleens as well as naive and LPS-treated dendritic cells from wildtype and GPR34-/- mice were ...
GSE75858: Frontal Cortex Transcriptome Analysis of Mice Exposed to Electronic Cigarettes During Early Life Stages
Our study demonstrated that e-cigarettes, both with and without nicotine, induced sex-dependent gene...
GSE72964: Tissue damage signals repurpose NF-B, AP-1 and Smad3 to direct a Rev-erb sensitive wound healing program in macrophages
A complex damage signal promotes co-localization of NFB and Smad3 at Rev-erb-sensitive enhancers and...
GSE75413: Single-cell transcriptomics reveals receptor transformations during olfactory neurogenesis
We report RNA sequencing of single olfactory neurons from mouse olfactory epithelium in developmenta...
GSE101621: Next Generation Sequencing Facilitates Quantitative Analysis of Splenic Macrophage Subpopulations identified by Ly6c and F4/80 Transcriptomes in mouse T cell acute lymphoblastic leukemia
The goals of this study aim to reveal functional and phenotypic diversity of Spleenic Macrophage sub...
GSE110249: Global gene expression profile of CD8+ TILs from WT and B7S1 KO mice
B7S1 negatively regulates T cells and its expression correlates with poor prognosis of cancer patien...
GSE71698: Multifunctional role of the transcription factor Blimp1 in coordinating plasma cell differentiation
Blimp1 is an essential regulator of plasma cells. Here we studied its functions in early plasmablast...
GSE71462: Differential expression of genes in photoreceptor and other retinal cells in developing retina
To analyze cell lineage specific global transcriptional changes during retinogenesis, we sequenced m...
GSE129489: Pro-survival Lipid Sphingosine-1-Phosphate Metabolically Reprograms T cell to Limit its Anti-Tumor Activity
Sphingosine 1-phosphate (S1P), a pro-tumor survival bioactive lysophospholipid, generated by sphingo...
GSE74517: Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin; germline Parkin knockout mouse hearts.
Dysfunctional Parkin-mediated mitophagic culling of senescent or damaged mitochondria is a major pat...
GSE137531: YAP1 and TAZ knockdown in human keratinocytes
RNA sequencing (RNAseq) of N/TERT2G keratinocytes transduced with pooled siRNAs targeting YAP1 and T...
GSE153958: Interactions of Monocytes, HIV, and ART Identified by an Innovative scRNAseq Pipeline: Pathways to Reservoirs and HIV-Associated Comorbidities
HIV reservoirs persist despite successful antiretroviral therapy (ART) and are a major obstacle to t...
GSE69707: Gene expression analyses and distribution of H3K4me3 modification during eosinophil development (GMP to EoP to Eosinophil)
To identify regulators of homeostatic eosinophilopoiesis in mice, we took a global approach to ident...
GSE97066: Celecoxib, Rofecoxib Gavage Treated Mice, Aorta RNA-Seq
Celecoxib, Rofecoxib Gavage Treated Mice, Aorta RNA-Seq SOURCE: Gregory,Robert,Grant (ggrant@upenn.e...
GSE108561: Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells
We molecularly characterized thousands of liver endothelial cells and immune cells using scRNAseq. W...
GSE75364: Reprogramming by de-bookmarking somatic transcriptional program via targeting the BET bromodomains
One critical task in pluripotent reprogramming is to erase the somatic transcriptional program of st...
GSE75664: Estrogen receptor coregulator binding modulators (ERXs) effectively target estrogen receptor positive human breast cancers
We examined the transcriptional chagnes modulated by ECBI-11 by perfroming global transcriptome anal...
GSE77722: Transcriptomic analysis of pancreas and kidney upon induction of reprogramming
We profiled total mRNA of pancreas and kidney tissues of 3 different strains (p53-null; In4a/Arf-nul...
GSE95072: RNAseq data from Mesenchymal stem cells treated with TCDD or 1-methyl tryptophan
Whole genome RNA-sequencing identified Nrf2, MAPK12 and IL-1a as important downstream targets of 1MT...
GSE76261: DNA demethylation by Tet dioxygenases controls gastrula patterning by regulating Lefty-Nodal signaling
Mammalian genomes are subjected to epigenetic modifications, including cytosine methylation by DNA m...
GSE99757: Low-input and multiplexed microfluidic assay reveals epigenomic variation across cerebellum and prefrontal cortex
There has been an extensive effort underway to profile epigenetic features at the genome-wide scale ...
GSE75787: Loss of Asxl1 Alters Self-Renewal and Cell Fate of Bone Marrow Stromal Cell
De novo ASXL1 mutations are found in patients with Bohring-Opitz syndrome, a disease with severe dev...
GSE100839: Ebola virus (EBOV) infection of ARPE-19 cells
We inoculated ARPE-19 human retinal pigment epithelial cells with EBOV, and followed course of infec...
GSE76875: Expression profiling of murine monosomal karyotype p53-/- shPU.1 AML cells following gradual PU.1 restoration
We have utilized advanced RNAi technology to dynamically restore endogenous PU.1 expression in p53-d...
GSE74804: The metabolic response to a high-fat diet reveals obesity-prone and -resistant phenotypes in mice with distinct mRNA-seq transcriptome profiles
We investigated phenotypic differences underpinning obesity susceptibility or resistance based on me...
GSE119274: Generation, transcriptome profiling, and functional validation of cone-enriched human retinal organoids
The macula of the retina has a high ratio of cones to rods and is critical for central vision and vi...
GSE113259: RNA-sequencing (RNA-seq) in BxPC-3 and S2-007 cell lines
RNA sequencing technology has been carried out in order to compare mRNA expression changes in epithe...
GSE74900: Transcriptome-wide analysis of gene expression regulated by LSD1 during brown adipocyte differentiation [RNA-seq]
By screening a collection of epigenetic compounds, we find that Lysine-Specific Demethylase 1 (LSD1)...
GSE69952: Calorie restriction suppresses age-dependent hippocampal transcriptional signatures.
Calorie restriction (CR) enhances longevity and mitigates aging phenotypes in numerous species. Phys...
GSE75677: Comparison of Liver Tumor Models to Regenerating Liver Tissues
To identify genes and pathways sepcific to tumorigenesis, we harvested tissues from two different li...
GSE76874: Expression profiling of murine cytogenetic normal p53-/- shPU.1 AML cells following gradual PU.1 restoration
We have utilized advanced RNAi technology to dynamically restore endogenous PU.1 expression in p53-d...
GSE120306: RNA-Seq of LRRK2 G2019S Parkinsons iPSC-derived astrocytes
Non-neuronal cell types such as astrocytes can contribute to Parkinsons disease (PD) pathology. The ...
GSE98974: Adult CNS Myelin Enhances Axonal Outgrowth From Neural Stem Cells
The growth of neural stem cells is strongly enhanced on myelin in vitro and in vivo. To identify the...
GSE74985: Hipposeq: an RNA-seq based atlas of gene expression in excitatory hippocampal neurons
Here, we used next-generation RNA sequencing (RNA-seq) to produce a quantitative, whole genome atlas...
GSE104054: Spatial reconstruction of immune niches by combining photoactivatable reporter and single-cell RNA-seq
Cellular function is strongly dependent on surrounding cells and environmental factors. Current tech...
GSE75639: Comparative transcriptomic and epigenomic analyses reveal new regulators of murine brown adipogenesis [Seq]
Increasing energy expenditure by promoting the thermogenic program in brown adipocytes is a promisin...