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Sequencing-based assays (Page 34)
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GSE67750: Chronic haloperidol effects on gene expression in mouse [RNA-seq]
We evaluate the effects of chronic administration of antipsychotic haloperidol versus placebo in mal...
GSE67265: Frequent and Transient Acquisition of Pluripotency During Somatic Cell Trans-Differentiation with iPSCs Reprogramming Factors (RNA-Seq)
Recent reports have proposed a new paradigm for obtaining mature somatic cell types from fibroblasts...
GSE69740: Menin-MLL inhibitors block oncogenic transformation by MLL fusion proteins in a fusion partner independent manner
Chromosomal rearrangements of the Mixed Lineage Leukemia (MLL) gene result in fusion proteins which ...
GSE136663: Dissection of FUS domains involved in regulation of SnRNP70 gene expression
To identify FUS regulated genes and its dependency of snRNP70, the gene expression profiles in neuro...
GSE67073: RNA sequencing of hiPSC derived neural crest populations from Familial Dysautonomia patients
We have generated expression profiles of induced pluripotent stem cells (iPSCs) and iPSC-derived neu...
GSE134510 (mouse): RNA sequencing of PD-L1 knock out human MDA-MB231 cells and mouse CT26 cells
Although membrane-anchored PD-L1 has been well-studied for its engagement with PD-1 on T cells to ev...
GSE67770: Splicing function of mitotic regulators links R-loop mediated DNA damage to tumor cell killing
We discovered that two mitotic regulators, BuGZ and Bub3, involved in splicing regulation during int...
GSE81494: Sirtuin 1 Promotes Nave Pluripotency by Deacetylation of Oct4 (RNA-seq)
The enhancer landscape is dramatically restructured as nave preimplantation epiblasts transition to ...
GSE66789: RNA-seq analysis of control and Myc-induced U2OS cells
We used RNA-seq to examine the effect of Myc activation on U2OS cells transcriptome. We also examine...
GSE110131: Lung transcriptomes of wild type, -arrestin 1 -/-, and -arrestin 2 -/- mice exposed to normoxia or chronic hypoxia
We found that -arrestin 1 -/- mice were more sensitive to hypoxia-induced pulmonary arterial hyperte...
GSE64684: Direct Reprogramming of Fibroblasts into Stable and Fully Functional Trophoblast Stem-like Cells by Defined Factors
The generation of induced pluripotent stem cells (iPSCs) and the direct conversion approach provide ...
GSE125567: 3Pool-seq: an optimized cost-efficient and scalable method of whole-transcriptome gene expression profiling (Run0004)
The advent of Next Generation Sequencing has allowed transcriptomes to be profiled with unprecedente...
GSE69786: Gene expression in wild-type vs. G2 -77 enhancer knockout myeloid progenitors
-77-/- mice exhibited late embryonic lethality, anemia, and a constellation of phenotypes. -77 confe...
GSE67333: Transcriptomics profiling of Alzheimers disease reveal novel molecular targets
Our data provide a comprehensive list of transcriptomics alterations and warrant holistic approach i...
GSE98360: UHRF2 regulates local 5-methylcytosine and suppresses spontaneous seizures [RNA-seq]
5-methylcytosine (5mC) regulates multiple cellular processes and is faithfully maintained following ...
GSE129941: RNA sequencing in kidneys of MUC1 Kidney Disease mouse model with and without treatment
MUC1 kidney disease mouse model generated by knock-in of the human mutated MUC1-fs gene. The mice we...
GSE73018: Alterations to the Synaptic Transcriptome in Response to Ethanol-Induced Behavioral Sensitization in DBA/2J Mice
Alcoholism is a complex neurological disorder characterized by loss of control in limiting intake, a...
GSE67240: Study the effect of SUZ12 on the responsiveness of IFNg target genes in multiple cancer and non cancer cell lines
We studied the effect of knocking down SUZ12 on the responsiveness of IFNg target genes SOURCE: Rod ...
GSE67266: WT and Mk2/3 KO MEFs response to etoposide
Primary mouse embryonic fibroblasts (MEFs) from wt and MK2/3 KO mice were treated with 20M etoposide...
GSE61346: Endogenous miRNA and target concentrations determine susceptibility to potential ceRNA competition, based on hierarchical binding affinities (mRNA)
Target competition (ceRNA crosstalk) within miRNA-regulated gene networks has been proposed to influ...
GSE68229: Illumina sequencing of vaginal epithelial cells from women using depot medroxyprogesterone acetate or non-hormonal contraception
The use of the hormonal contraceptive DMPA has been associated with a moderate increase in sexually ...
GSE66798: The acetyllysine reader BRD3R promotes human nuclear reprogramming and regulates mitosis
It is well known that both recipient cells and donor nuclei demonstrate a mitotic advantage as obser...
GSE67112: The Expansion of Thymopoiesis in Neonatal Mice is Dependent on Expression of High mobility group A 2 protein (Hmga2)
The most immature progenitors in the murine thymus are early T lineage progenitors (ETP). These cell...
GSE115243: Drop-Seq analysis of rTg4510 mouse hippocampus and control at young and old age
Single cell suspension of hippocampus was generated and single cell mRNAseq libraries were prepared ...
GSE69970: Transcriptome of mouse preimplantation development [Rlim KO]
Purpose: The goals of this study are to establish a roadmap of XCI and compare the transcriptomes of...
GSE64960: Sexual cell fate reprogramming in the ovary by DMRT1
Transcription factors related to the insect sex determination gene Doublesex (DMRT proteins) control...
GSE69807: Critical role of histone turnover in neuronal transcription and plasticity [RNA-seq]
Turnover and exchange of nucleosomal histones and their variants, a process long believed to be stat...
GSE116086: HDAC inactivation by EP300 disrupts the MiCEE complex in Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and highly lethal lung disease with un...
GSE74978: Transcriptome-wide regulation of pre-mRNA splicing and expression by the RNA-binding protein Quaking during monocyte to macrophage differentiation [RNA-Seq]
Expression levels of the RNA-binding protein Quaking (QKI) are low in monocytes of early, human athe...
GSE69974: BCL6 evolved in vertebrates as a stress tolerance gene and is broadly used by cancer cells to adapt to stress
We have found that BCL6 is a component of the conserved stress response program regulated by HSF1. B...
GSE66357: Scalable Microfluidics for Single Cell RNA Printing and Sequencing
Single cell transcriptomics has emerged as a powerful approach to dissecting phenotypic heterogeneit...
GSE63510: Nck2 Regulates Adiposity and Adiposity-Related Metabolic Disorders in Mice and Human
Obesity is linked to the development of metabolic disorders. Expansion of white adipose tissue (WAT)...
GSE69556: Next Generation Sequencing of PKD2 mutant mice kidneys
This Study sought to understand the differential gene expression profile of Pkd2 mutant mice kidneys...
GSE70000: Ubiquitin-dependent turnover of MYC promotes loading of the PAF complex on RNA Polymerase II to drive transcriptional elongation (RNA-seq)
The MYC transcription factor is an unstable protein and its turnover is controlled by the ubiquitin ...
GSE100990: NR4A1 and NR4A3 Restrict HSC Proliferation via Reciprocal Regulation of C/EBP and Inflammatory Signaling
NR4A nuclear receptors are known tumor suppressors of acute myeloid leukemia and are essential regul...
GSE78779: CEL-Seq2: sensitive highly-multiplexed single-cell RNA-Seq
Single-cell transcriptomics requires a method that is sensitive, accurate, and reproducible. Here, w...
GSE98401: MEF2C restrains microglial responses to inflammatory stimuli and is reduced upon IFN-I in brain aging
RNA-Seq data of micoglia isolated from brains of indicated mouse types. SOURCE: Ido Amit (ido.amit@...
GSE67128: Comparative whole-transcriptomic analysis between normal and AKAP-Lbc-depleted human embryonic stem cells
Human embryonic stem cells (hESCs) have the unique property of immortality, ability to infinitely se...
GSE109957: Silencing p300 in MCF7 cells to study expression and alternative splicing
Splicing of precursor mRNA (pre-mRNA) is an important regulatory step in gene expression. Recent evi...
GSE67310: Dissecting the direct reprogramming path of fibroblasts into neurons by single cell RNA-sequencing
Direct lineage reprogramming represents a remarkable conversion of cellular and transcriptome states...
GSE73472: In vivo characterization of Linc-p21 reveals functional cis-regulatory DNA elements
We have sequenced wildtype and mutant heart, liver, lung, and hindlimb from E14.5 embryos of the mut...
GSE94939: Transcriptome of IL-19 negative and IL-19 positive macrophages.
RNA-seq analysis of LPS stimulated bone marrow-derived macrophages, derived from heterozygous Il19-t...
GSE65753: Analysis of wildtype and Xbp1-deficient hematopoietic progenitor cell transcriptomes
Purpose: The goals of this study are to assess the transcriptional networks governed by the transcr...
GSE100588: PPAR in DCs and T cells drives pathogenic type-2 effector responses in lung inflammation
We compare GW9662 (PPARg antagonist) treated CD4+ T cells under Th2 coculture conditions with vehicl...
GSE67691: Myc and SAGA Rewire an Alternative Splicing Network During Early Somatic Cell Reprogramming [mESCs_RNASEQ]
Embryonic stem cells are maintained in a self-renewing and pluripotent state by multiple regulatory ...
GSE68283: Next Generation Sequencing Analysis of Wild Type and Rfx2-/- Testicular Transcriptomes [RNA-Seq P30]
Purpose: This study was carried out to determine the consequences of the Rfx2-/- genotype on spermat...
GSE134876: Reciprocal regulation of EGR1 and EZH2 in breast cancer cells
We found that EGR1 stimulates the expression of EZH2, which in turn inhibited the expression of EGR1...
GSE77744: Essential role of the transcription factors E2A and E2-2 in germinal center B cell and plasma cell development
E2A is an essential regulator of early B-cell development. Here we demonstrated that E2A together wi...
GSE132340: Hierarchy of mono- and bi-allelic TP53 alterations in Multiple Myeloma cell fitness
Comparison of the TP53 wild-type myeloma cell line AMO1 with the CRISPR/Cas9 engineered AMO1 cell li...
GSE70123: Adipose Rab10 Knockout Causes Insulin Resistance through Impaired Glucose Uptake
Insulin action in adipocytes affects whole-body insulin sensitivity. Studies of adipose-specific Glu...
GSE70731: MIWI2 and MILI have differential effects on piRNA biogenesis and DNA methylation
In developing male germ cells, prospermatogonia, two Piwi proteins, MILI and MIWI2, use piRNA guides...
GSE70148: A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2alpha [gene expression]
Lamins are components of the peripheral nuclear lamina and interact with heterochromatic genomic reg...
GSE74889: The direction of cross affects obesity after puberty in male but not female offspring
We investigated parent-of-origin and allele-specific expression effects on obesity and hepatic gene ...
GSE132364: Single-cell transcriptomics of the embryonic mouse pancreas
Data accompaning to van Gurp et al. Development 2019. single-cell sequencing of the developing mouse...
GSE64910: HP1 is involved in regulating the global impact of DNA methylation on alternative splicing
The global impact of DNA methylation on alternative splicing is largely unknown. Using a genome-wide...
GSE70156: Nuclear Transfer nTreg model reveals fate-determining TCRbeta and peripheral nTreg precursors
To study the development and function of natural-arising T regulatory (nTreg) cells, we developed a ...
GSE70135: Signaling through MyD88 in bone marrow-derived cells promotes gastric tumorigenesis by inducing the TLR2/CD14 pathway in tumor cells
Gan mice express Wnt1, Ptgs2, and Ptges, which develop inflammation-associated gastric tumors (Oshim...
GSE70896: RNA sequencing of olfactory bulb projection neurons in neurotensin-GFP (NTS-GFP) mice at different developing time points
Characterize the spatiotemporal dynamics of gene expression in neurons in developing olfactory bulb ...
GSE76069: Comparison between immune cells from mice challenged with Bacille Calmette Gurin (BCG)
Microglia and macrophages are immune cells that differ in the inflammatory response to immune challe...
GSE66054: MicroRNA-203 represses selection and expansion of oncogenic HRas transformed tumor initiating cells [seq]
In many mouse models of skin cancer, only a few tumors typically form although many cells competent ...
GSE125793: RNA sequencing of whole Dorsal Root Ganglia (DRG) and laser captured large diameter DRG neurons upon Environmental Enrichment (EE) compared to Standard Housing (SH)
Purpose: A) compare the gene expression in whole DRG and in large diameter DRG neurons of mice expos...
GSE133212: Conditional Activation of NF-kB Inducing Kinase (NIK) in the Osteolineage Enhances both Basal and Loading-Induced Bone Formation
Studies from global loss-of-function mutants suggest that alternative NF-kB downstream of NF-kB indu...
GSE66138: Gene expression differences in yolk sac tissue between wild-type and Zfp36l3 knockout mice
The ZFP36L3 protein is a rodent-specific, placenta- and yolk sac-specific member of the tristetrapro...
GSE114952: Single-Cell RNA-Seq Reveals Dynamic Early Embryonic-like Programs during Chemical Reprogramming
We profile 36,199 single-cell transcriptomes at multiple timepoints throughout a highly efficient ch...
GSE68265: Dissection of the translational impacts of the PERK pathway
Disruptions of protein homeostasis in the endoplasmic reticulum (ER) elicit activation of the unfold...
GSE145837: Transcriptome analysis of tumor infiltrating NK and T cells in CT26-bearing BALB/C mice
CT26 tumors were implanted subcutaneously into syngeneic BALB/C mice and allowed to grow for 15-25 d...
GSE96711: Epigenomic conservation of transposable element silencing [RNA-seq]
Transposable elements (TEs) comprise a substantial proportion of primate genomes. Because of the pot...
GSE69227: Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B-cell progenitors
In order to investigate how transcription factor dose impacts B-lymphocyte development, we generated...
GSE119982: SMARTer single cell total RNA sequencing [SHSY5Y-MYCN-TR]
single cell polyA+ and total RNA-seq data was generated for NGP, SK-N-BE-2C and SHSY5Y-MYCN-TR cells...
GSE69823: Global and Targeted DNA Demethylation during iPSC Reprogramming
Global DNA demethylation occurs in vivo in the early embryo and primordial germ cells, and in vitro ...
GSE68746: Next Generation Sequencing (NGS) comparison of two MVT1 cells subpopulations, CD24- cells and CD24+ cells
The goal of this study is to compare the transcriptome of the 2 MVT1 subpopulations in order to iden...
GSE62642: RNA-Seq Analysis in purified iPS cell-derived neuronal samples
We characterized the gene expression differences in mDA neurons from all PD (Parkinson's disease) ca...
GSE69276: Notch1 dose modulates endothelial gene expression
Purpose: To use RNA-Seq analysis of endothelial cell in various Notch1 alllels in order to determine...
GSE76025: Pluripotent stem cell disease modeling of GATA6 haploinsufficiency in human pancreatic development
To better understand molecular mechanisms of human pancreatic development associated with GATA6 hapl...
GSE67572: Regulation of Gene Expression Dynamics during Developmental Transitions by the Ikaros Transcription Factor
The DNA-binding protein, Ikaros, functions as a potent tumor suppressor and hematopoietic regulator....
GSE68323: RNA expression in primary huamn muscle cells treated with 1,25(OH)2D3 or vehicle
We report the effects of 1,25(OH)2D3 treatment on the mRNA expression in human muscle cells SOURCE: ...
GSE68671: Differential regulation of alternatively polyadenylated isoforms
Alternative Cleavage and Polyadenylation (APA) plays a crucial role in the regulation of gene expres...
GSE69855: Next Generation RNAseq of neonatal hearts one day post surgery comparing sham, apical resection or apical resecection plus vagotomy treatments
We report global RNA expression profiles in whole heart ventricle tissue from postnatal day 2 mice t...
GSE70330: ncRNA (non-coding RNA) signature in endothelial cells during hypoxia [RNA-seq]
To define ncRNA expression in hypoxic endothelial cells, we applied pro-angiogenic hypoxia to cultur...
GSE122709: LncRNA expression profiling of ischemic stroke patients
Our study reveals that ischemic stroke can influence the expression of LncRNAs and mRNAs in the peri...
GSE66366: RNA sequencing of a C57BL/6J-DBA/2J (B6.D2) congenic mouse and C57BL/6J (B6) wild-type littermates reveals cis and trans differences in gene expression
We previously utilized interval-specific congenic lines derived from C57BL/6J (B6) and DBA/2J (D2) ...
GSE67382: BAF controls genome accessibility
Somatic differentiation requires induction of lineage specific genes to fulfill specialized tissue f...
GSE71164: Decrease in EZH2 histone methyltransferase mediates the effects of fluid shear stress (FSS) in endothelial cells
High uniform fluid shear stress (FSS) is atheroprotective and preserves the endothelial phenotype an...
GSE70304: RNA-seq analysis of transcriptome changes upon Erk knockout, or Mek inhibition in WT and Erk KO ESCs.
RNA-seq were performed with six samples, WT KH2 ESCs treated with or without PD0325901 for 48 hours ...
GSE65207: Two-signal requirement for growth-promoting function of Yap
The transcriptional coactivator Yap promotes proliferation and inhibits apoptosis, suggesting that Y...
GSE68270: Lysophosphatidic acid receptor expression identifies a pure population of adult hippocampal stem cells with an immune cell-related transcriptional profile
Lysophosphatidic acid receptor 1 (LPA1) is a phospholipid which has been linked to adult hippocampal...
GSE68736: STAT3 Regulates Adult Muscle Satellite Cell Maintenance During Injury-induced Muscle Regeneration
We previously showed that STAT3 regulates myoblast differentiation in cell culture models, yet its r...
GSE142867: HIF-1 directly induces TET3 expression to redistribute 5-hydroxymethylcytosine and induce erythroid gene expression in hypoxia [RNA-seq]
We performed RNA-sequencing on erythropoietic cells cultured in normoxia or hypoxia at days 3,7, and...
GSE99047: Sema6D reverse signaling controls lipid metabolism for macrophage polarization linking mTOR to PPAR
Purpose: The goal of this study is to compare downstream genes of Sema6D signaling in LPS plus IFNg ...
GSE65617: Differential features of Aire-induced and Aire-independent promiscuous gene expression in thymic epithelial cells
Promiscuous gene expression (pGE) of numerous self-antigens in thymic epithelial cells (TEC) enables...
GSE124068: Transcriptome analysis of mdx hearts and skeletal muscles treated with cardiac progenitor cells and their exosomes
Aged mdx mice were treated with 2.5x105 cardiosphere-derived cells (CDCs) or 2.0x109 exosomes intrav...
GSE69622: Landscape of Hematopoiesis Described in Induced Pluripotent Stem Cells and Human Bone Marrow
Granulopoietic differentiation of myeloid progenitor cells derived from control iPSCs was performed...
GSE98964: Genomic analysis of Tet2 knockout macrophages
Ten-Eleven-Translocation-2 (Tet2) is a DNA methylcytosine dioxygenase that functions as a tumor supp...
GSE68341: Genome-Wide Specificity of DNA-Binding, Gene Regulation, and Chromatin Remodeling by TALE- and CRISPR/Cas9-Based Transcription Factors
Synthetic DNA-binding proteins have found broad application in gene therapies and as tools for inter...
GSE69889 (mouse): Genome-wide Circadian Control of Transcription at Active Enhancers Regulates Insulin Secretion and Diabetes Risk
The molecular clock is a transcriptional oscillator present in brain and peripheral cells that coord...
GSE70368: Nurr1 and Retinoid X Receptor ligands stimulate Ret signaling in dopamine neurons and can alleviate -synuclein disrupted gene expression
We ovexpressed human alpha synuclein alone or together with Nurr1 in mouse primary midbrain cultures...
GSE63526: Spontaneous pancreatitis caused by tissue-specific gene ablation of Hhex in mice
Background & Aims: Perturbations in pancreatic ductal bicarbonate secretion often result in chronic ...
GSE106488: Temporal Changes in Macrophage Phenotype after Peripheral Nerve Injury
Identification of temporal changes in gene expression in macrophages isolated from the site of nerve...
GSE70830: Gene expression and splicing alterations analyzed by high throughput RNA sequencing of chronic lymphocytic leukemia specimens
Background: To determine differentially expressed and spliced RNA transcripts in chronic lymphocytic...
GSE68713: Propogation of anxiety-traits through the maternal line via parallel and segregated gametic and non-gametic epigenetic mechanisms
Maternal stress, anxiety, and depression increase the risk of psychiatric disorders in the progeny. ...