PLX066310

GSE99047: Sema6D reverse signaling controls lipid metabolism for macrophage polarization linking mTOR to PPAR

Organsim mouse
Type RNASEQ
Target gene
Project ARCHS4

Purpose: The goal of this study is to compare downstream genes of Sema6D signaling in LPS plus IFNg stimulated macrophages.; Methods: Bone marrow derived macrophage mRNA profiles of 7 weeks of wild type (WT) and Sema6D-/- mice were stimulated by LPS for 4 hrs.; Results: According to this comparison, we found that 550 genes were downregulated in Sema6D-/- macrophages than WT macrophages in response to LPS.; Conclusions: Our study represents 62 genes were supressed in both M1 and M2 Sema6D-/- macrophage than WT macrophages, suggesting of Sema6D reverse sigaling genes. SOURCE: Daisuke Okuzaki (dokuzaki@biken.osaka-u.ac.jp) - RIMD, Osaka univ.

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