PLX285792

GSE100990: NR4A1 and NR4A3 Restrict HSC Proliferation via Reciprocal Regulation of C/EBP and Inflammatory Signaling

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

NR4A nuclear receptors are known tumor suppressors of acute myeloid leukemia and are essential regulators of hematopoietic stem cell (HSC) quiescence. To study the transcriptional consequences of acute NR4A1/3 codepletion in HSCs, we used an Nr4a1/3 conditional knockout mouse model and performed a global transcriptome profiling using RNA-Seq in sorted HSCs four days after NR4A1/3 codepletion. SOURCE: Pablo,Riera,Freire (freire@bcm.edu) - Baylor College of Medicine

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