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Sequencing-based assays (Page 57)
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GSE102756: Alteration of gene expression in cumulus cells reveals the role of ClpP in reproductive aging
We performed RNAseq analysis to determine the effect of ClpP-deletion on cumulus cells global gene e...
GSE102007: Gene expression profiling of murine skin transgenically generated to express HPV16 E7 oncoprotein
A validated animal model would assist with research on the immunological consequences of the chronic...
GSE104055: Transcriptomic Profiling of Mice with Klf5 Deletion in Context of Oncogenic Kras Expression
This study used Illumina RNA-sequencing to examine transcriptomic profile of mice with Klf5 knockout...
GSE105143: H.pylori infections induces a transcriptional signature in gastric eosinophils, as determined by RNA sequencing
Eosinophils are highly abundant throughout the gastrointestinal tract. However, their function in ba...
GSE107422: Gene expression profiling study to identify key markers associated with disease recurrence in colorectal cancers.
The objective of this study is to identify a gene set to predict recurrence of colorectal cancer (CR...
GSE103082: Resistance to BET inhibitor leads to new therapeutic vulnerabilities in castration resistant prostate cancer
BRD4 plays a major role in the transcription networks orchestrated by androgen receptor (AR) in cast...
GSE102277: Determination of Nir (Noc2l) function in epidermis during mouse development by global transcriptome analysis
To investigate the role of Nir in epidermis during embryogenesis, we crossed mice harboring conditio...
GSE113979: A central extended amygdala circuit that modulates anxiety
Both the amygdala and the bed nucleus of the stria terminalis (BNST) have been implicated in maladap...
GSE99491: Enhancing the Potency of Mouse Embryonic Stem Cells [RNA-Seq]
Mouse nave pluripotent stem cells (ESC) can contribute to all embryonic tissues and the germline, bu...
GSE101913: Species and Cell-Type Properties of Classically Defined Human and Rodent Neurons and Glia [Human RNA-Seq]
Determination of the molecular properties of genetically targeted cell types has led to fundamental ...
GSE102783: RNA-seq in spermatogonia from PRC1ctrl and dKO mice
RNA-seq was performed using Thy1- and c-Kit+ spermatogonia from 7-days-old PRC1ctrl or dKO mice. SOU...
GSE97302: SPT6 interacts with NSD2 and facilitates interferon-stimulated transcription
SPT6, encoded by the SUPT6H in humans and Supt6 in mice, respectively, is a conserved histone chaper...
GSE95445: Single cell RNA-seq of 444 epithelial cells from the mammary glands of pubescent and adult mice
Mammary glands were collected from 8 pubescent (4.7-4.9 week-old) female mice and 8 adult (10 week o...
GSE101994: RNAseq of B16 inoculated tumor-assotiated macrophages from MC-proficient and MC-deficient animals
RNA seq was used to compare the expression profile of macrophages in presence and absense of mast ce...
GSE102768: Effect of CBL0137 on gene expression in mouse cells and tissues
We analyzed changes in abundance of RNAs in mouse embryonic fibroblasts (MEF) from wild type and p53...
GSE140419: Transcriptional characterization of tissue-Tregs and whole tissues of skeletal muscles in muscle Treg TCR transgenic mice.
Foxp3+CD4+ regulatory T cells (Tregs) play important roles in controlling both homeostatic processes...
GSE96539: Identification of lineage-specific transcription factors setting the active distal regulatory landscape that drives astrogliogenesis
The gene regulatory mechanisms that steer neural stem cells towards astrocytes during brain developm...
GSE101701: Changes in mRNA Expression of Mouse Epicardial Explans following Epicardial EMT Treated with Blebbistatin to Inhibit Nonmuscle Myosin II Activity
Inhibition of Nonmuscle Myosin II impairs mesenchymal gene expression during epicardial EMT. SOURCE:...
GSE103405: OMICS assisted N-terminal proteoform and protein expression profiling upon methionine aminopeptidase 1 (MetAP1) deletion
Excision of the N-terminal initiator methionine (iMet) residue from nascent peptide chains is an ess...
GSE110042: TRAPSeq identifies transcripts enriched/de-enriched in mouse GnRH neurons.
We utilized translating ribosome affinity purification (TRAP) coupled with RNA sequencing to examine...
GSE102211: Transcriptional changes in mouse lungs induced by house dust mite
We examined the transcriptional changes in mouse lungs induced by house dust mite (HDM), D.f. extrac...
GSE103103: Discrete WT1-positive hepatic fibrogenic cell lineages of distinct developmental mesothelial origin are paradoxically inhibited by WT1
Activated hepatic stellate cells orchestrate scar formation during fibrotic liver injury. Recent evi...
GSE96981 (mouse): Multilineage communication regulates human liver bud self-organization from pluripotency II
Conventional 2-D differentiation from pluripotency fails to recapitulate cell interactions occurring...
GSE103928: Genomic basis for clinical response to histone deacetylase inhibition in advanced urothelial carcinoma
Abstract Background: Histone deacetylase (HDAC) inhibition has shown some efficacy in urothelial ca...
GSE105153: Transcriptome of TNF-a-treated and untreated HeLa cells before and after TFIIB knockdown
The goal of this study was to compare transcriptome of HeLa cells with or without TFIIB knockdown fo...
GSE94581: Lymphocyte Activation Gene-3 limits regulatory T cell proliferation and function in autoimmune diabetes
Inhibitory receptors (Irs) are pivotal in controlling T cell homeostasis because of their intrinsic ...
GSE108196: Effect of Sumo2 deletion on gene expression in the mouse brain
Mounting evidence indicates that small ubiquitin-like modifier (SUMO) conjugation regulates a wide r...
GSE103976: Detecting Activated Cell Populations Using Single-Cell RNA-Seq
Single-cell RNA sequencing of mouse amygdala using Drop-Seq SOURCE: Ye,Emily,Wu UCLA
GSE134432: Single-cell analysis of gene expression variation and phenotype switching in melanoma
We combine extensive profiling of single-cell gene expression (scRNA-seq of 39,263 cells) and chroma...
GSE108654: LIN28B is a barrier to the maturation of human embryonic stem cell derived pancreatic cells
Comparative RNA and small RNA sequencing analysis of in vitro differentiated like cells, in vivo ma...
GSE94546: Autonomous TNF is critical for monocyte survival in steady state and inflammation in vivo
Monocytes are circulating mononuclear phagocytes, poised to extravasate to sites of inflammation and...
GSE102757: Comparison of gene expression between control and Panobinostat treated Notch1-driven T-ALL
T-cell acute lymphoblastic leukaemia (T-ALL) is a disease characterized by the uncontrolled clonal p...
GSE94525: Microglia isolated from juvenile offspring of dams with allergic asthma exhibit methylation and transcriptional alterations to autism risk genes [RNA-Seq]
Asthma is one of the most common chronic diseases among pregnant women, and symptoms often worsen du...
GSE104292: Spatiotemporal role of the lncRNA Evx1as in embryonic patterning
We performed spatial transcriptome analysis on cryosections of gastrulating embryos from E6.5 to E7....
GSE103154: Tracing the temporal-spatial transcriptomic landscapes of the human fetal digestive tract by single cell RNA-seq analysis [adult tissues]
Here, using a modified STRT-seq protocol, we analyzed the large intestine (LI) from two adults.In de...
GSE117166: Single cell RNAseq integrates T cell phenotypes associated with Listeria infection in mice
Mice were inoculated with Listeria by i.p. injection on days 0 and 11. On day 18, FSC(high)CD4(+)CD8...
GSE103127: Expression profiling of Morc2b wt and Morc2b ko testes
We report the effect of Morc2b inactivation on the transcriptome of testes at postnatal day 12 (PND1...
GSE96993 (mouse): Targeted reconstruction of T cell receptor sequence from single cell RNA-seq links CDR3 length to T cell differentiation state
The T cell compartment must contain diversity in both T cell receptor (TCR) repertoire and cell stat...
GSE129456: Of eyes and embryos; subfunctionalization of the CRX homeobox gene in mammalian evolution
We have ectopically expressed two V5-tagged homeobox genes and a control plasmid in mouse embryonic ...
GSE103990: Tumor evolution and drug response in patient-derived organoid models of bladder cancer
Bladder cancer is the fifth most prevalent cancer in the U.S., yet is understudied and relatively la...
GSE104406: Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia (RNA-Seq of HSCe)
Aging is associated with functional decline of hematopoietic stem cells (HSC) as well as an increase...
GSE103456: RNA-seq analysis of transcriptomes of IL35-Treg cells and the Blimp1-Treg cells
To gain in depth transcriptional information about the two subsets of effector Tregs, we performed R...
GSE100406: Binding of High Mobility Group A proteins to the mammalian genome occurs as a function of AT-content [RNA-Seq]
High mobility group (HMG) proteins are of similar size as histones with HMGA1 and HMGA2 being partic...
GSE102789: RNAseq of duodenal tissue from C57BL/6 mice both susceptible and resistant to Heligmosomoides polygyrus
Purpose: Identify genes implicated in resistance to H. polygyrus; Method: RNA was extracted from duo...
GSE94583: Primary Tumor-Derived Liver Cancer Organoids Promote Metastasis in vivo
Past studies have identified hepatic tumors with mixed hepatocellular carcinoma (HCC) and cholangioc...
GSE103471: Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma
We isolated RNAs from hematopoietic stem and progenitor cells (HSPCs). We compared two groups of mic...
GSE103386: Impact of Ezh2 deficiency on differentiation of follicular helper T (Tfh) cells
Comparison of transcriptome between control and Ezh2-deficient follicular helper T cells SOURCE: Hai...
GSE96684: RNA-Sequencing and proteomics approaches reveal multi-cellular deficits in the cortex of Rett syndrome mice
Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in the transcript...
GSE98969: Single cell RNA-seq identifies a unique microglia type associated with Alzheimers disease [RNA]
Alzheimer's disease (AD) is a detrimental neurodegenerative disease with no effective treatments. Du...
GSE105130: Comprehensive analysis of Transcriptome Profiles in Hepatocellular Carcinoma patients
Purpose: The goal of this study is to get a comprehensive evaluation of the transcriptome profile of...
GSE102299: Neuromedin U receptor-1 amplifies inflammatory lung innate lymphoid cells
Type 2 innate lymphoid cells (ILC2s) promote mucosal homeostasis, yet also contribute to pathologic ...
GSE102852: The deregulated microRNAome contributes to the cellular response to aneuploidy [mRNA]
Aneuploidy severely alters cell physiology and is widespread in cancers and other pathologies. In mo...
GSE95688: Analysis of the glutathione-deficient lens transcriptome
Purpose: To better understand the effects of glutathione (GSH)-deficiency on lens homeostasis and ca...
GSE103133: RNA-seq of peritoneal macrophages from wildtype and miR-33-/- mice under normal or hyperlipidemic conditions
Purpose: Previous work has demonstrated that miR-33 is an important regulator of lipid metabolism a...
GSE110142: Differential expression in wild type and mutant HAP1 cells [RNA-seq I]
using RNA-seq we characterized gene expression changes occuring upon knockout of BAP1, ASXL1, ASXL2,...
GSE105160 (human): RNASeq of mouse, human, and non-human primate primary dermal fibroblasts to poly(I:C) transfection
Here, we performed RNA-Seq on mRNA isolated from primary dermal fibroblasts of human, mice and multi...
GSE112397: Colonization of the Ovary and Metastasis of Fallopian Tube Derived Cancer
This experiment was designed to compare changes in the transcriptome of fallopian tube epithelial ce...
GSE96677: The nuclear RNA exosome is co-opted to enhance host:viral RNA hybrids that propel influenza virus ribogenesis and infectivity
The nuclear RNA exosome is an essential multi-subunit complex that controls RNA homeostasis. Congen...
GSE102864: PTP4A1 phosphatase is overexpressed in systemic sclerosis fibroblasts and promotes TGFb signaling
We show that silencing of tyrosine phosphatase PTP4A1 attenuates pro-fibrotic TGFb signaling in huma...
GSE106119: Stromal Mir-20a modulates paracrine CXCL8 secretion in colitis and colon cancer
We report the results of RNA-Seq on fibroblasts cultivated from cancerous, colitic and normal primar...
GSE103152: Improved Detection of Circulating Epithelial Cells in Patients with Intraductal Papillary Mucinous Neoplasms
Circulating epithelial cells (CECs) were purified using a microfluidic device from healthy donors, p...
GSE103057 (human): BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis
Transcription factor (TF) networks determine cell fate in hematopoiesis. However, how TFs cooperate ...
GSE95543: KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination
Maintenance of muscle function requires assembly of contractile proteins into highly organized sarco...
GSE102870: RNA-seq analysis of iPSC-derived heptocytes with mutations in NR1H4
We discovered a rare missense mutation in NR1H4 (R436H), which encodes the farnesoid X receptor (FXR...
GSE103359: Epigenetic correction of defective plasticity in a tauopathy mouse model with an acetyltransferase activator [RNA-Seq]
In the adult brain, histone acetylation is associated with activity-regulated transcriptional change...
GSE99588: Reduced diploidization and survival improvement of semi-cloned mice produced from androgenetic haploid embryonic stem cells
We found that the overall DNA methylation and hydroxymethylation in AG-haESCs are extremely low, and...
GSE103506: Alveolar Injury and Regeneration Following Deletion of ABCA3
Surfactant deficiency, diffuse alveolar damage and respiratory failure caused by loss of Abca3 in AT...
GSE102349: Genomic Analysis of Nasopharyngeal Carcinoma Reveals TME-based Subtypes
We performed an integrated genomic analysis of NPC using a large clinical cohort of treatment-nave t...
GSE99604: Gene expression changes in Ing1- and Gadd45a- single- or double-knockout mouse embryonic fibroblasts during adipogenesis
ING1b and GADD45a are nuclear proteins involved in the regulation of cell growth, apoptosis and DNA ...
GSE111423: circRNA profile in hypopharyngeal cancer
3 normal samples and 3 tumor samples were sequenced SOURCE: Baowei Jiao (jiaobaowei@mail.kiz.ac.cn) ...
GSE106592: Silencing SPIB in attached and floating state of H1703 lung cancer cells
To gain mechanistic insight into the role of SPIB in anoikis resistance, we assessed the transcripti...
GSE102377: Metastasis in triple negative breast cancer is dependent on Np63/CXCL2/CCL22-mediated recruitment of myeloid-derived suppressor cells
Gene expression analysis of the knockdown of NP63 in two different human breast cancer cell lines us...
GSE108156: Microbial activities associated with human intestinal mucosal biofilms change mRNAs and microRNAs to promote carcinogenesis in mice [RNA]
Disrupted interactions between host and intestinal bacteria are implicated in the development of col...
GSE95762: Multi-cellular Transcriptional Profiling Reveals an Epigenetic Barrier to Adult Heart Regeneration [RNA-Seq]
Background - The inability of the adult mammalian heart to regenerate following injury represents a ...
GSE110139: Defining CBX7-dependent chromatin architecture with rapid small-molecule inhibition
While the repressive roles of Polycomb complexes have been well-established with in vitro systems, i...
GSE103907: LNCaP treated with iBET
BRD4 belongs to the bromodomain and extraterminal (BET) family of epigenetic reader proteins that bi...
GSE108803: Genome-wide chromatin accessibility and transcriptome profiling shows that minimal epigenome changes lead to coordinated transcriptional dysregulation of hedgehog signaling in Danforths short tail mice (RNA-seq)
Danforths short tail (Sd) mice provide an excellent model for investigating the underlying etiology ...
GSE95781: Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability
Histone H3 lysine 4 monomethylation (H3K4me1) is an evolutionarily conserved feature of enhancer chr...
GSE106683: The Zmiz1-Notch1 interaction induces Myc expression to drive steady state and stress thymopoiesis [DN3]
Notch1 signaling ramps up to very high levels in order to drive CD4-CD8- double-negative (DN) thymoc...
GSE106836: Novel Principles of Cellular Reprogramming Revealed by Prospective Isolation and Characterization of Rare Intermediates Poised to Generate iPSCs [RNA-seq 2]
Cellular reprogramming converts differentiated cells into induced pluripotent stem cells (iPSCs). Ho...
GSE102315: Nutritional control of protein translation
Regulation of protein translation is a key feature of many biological processes. Global protein tran...
GSE99622: Sex differences in microglial developmental gene expression programs
During normal neurodevelopment, microglia perform a range of different functions that are crucial fo...
GSE103372: TGF-b utilizes a novel receptor activation mechanism to phosphorylate SMAD1/5 and regulate epithelial-to-mesenchymal transition
TGF-b treatment leads to the transcriptional regulation of many genes. However, the proportion of th...
GSE101810: Bmp signaling maintains a mesoderm progenitor cell state in the mouse tailbud
Caudal somites are generated from a pool of progenitor cells located in the tailbud region. These pr...
GSE39081: Genetically-driven target tissue over-expression of CD40: A novel mechanism in autoimmune disease
The CD40 gene, an important immune regulatory gene, is also expressed and functional on non-myeloid ...
GSE119480: RNAseq Data of Neural Stem Cells, Glial progenitors and Sox1 positive Glial progenitors
With this study we aimed to characterize the changes invoked in glial progenitor cells by activation...
GSE102903: Neuronal EphB1 induces STAT3 activation in astrocytes, which is impaired in ALS models [Mm]
Astrocyte responses to neuronal injury may be beneficial or detrimental to neuronal recovery, but th...
GSE151844: RNA-seq of mice islets from wt and miR-29a/b-1 pancreatic beta cell specific overexpression transgenic mice
We investigated the mechanism associated with miR-29 effects by comparing gene expression of whole p...
GSE104545: The ARID1A tumor suppressor controls global transcription via pausing of RNA Polymerase II
We investigated the genomic consequences of the depletion of the SWI/SNF subumit ARID1A, in an ovari...
GSE102346: Regulation of m6A transcripts by the 35 RNA helicase YTHDC2 is essential for a successful meiotic program in the mammalian germline
N6-methyladenosine (m6A) is an essential internal RNA modification that is critical for gene expres...
GSE93574: Regulation of mRNA translation and subcellular location controls protein synthesis of key modulators of the DNA damage response during B cell activation [RNA-seq]
Post-transcriptional regulation of cellular mRNA is essential for protein synthesis. Here we describ...
GSE108197: The RNA exosome adaptor protein ZFC3H1 functionally competes with nuclear export activity to retain target transcripts
Mammalian genomes are promiscuously transcribed, yielding protein-coding and non-coding products. Ma...
GSE103202: Identification of genes regulated by long noncoding RNA H19 in skeletal muscle
Soleus muscle has the most abundant H19 expression compared to other skeletal muscle tissues. In ord...
GSE103545: RNA-sequencing of MHC-cycD2 transgenic mice after Transverse Aortic Constriction and Aortocaval Shunt surgery
Expression profiling by high throughput sequencing of mice overexpressing cyclin D2 compared to WT c...
GSE103568 (human): Sensitive and powerful single-cell RNA sequencing using mcSCRB-seq
Single-cell RNA sequencing (scRNA-seq) has emerged as a central genome-wide method to characterize c...
GSE104461: Deciphering the combinatorial influence of diet and the microbiota on experimental colitis
Background & Aims: The complex interactions between diet and the microbiota that influence mucosal i...
GSE102345: Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature
The concept that solid tumors are maintained by a productive interplay between neoplastic and non-ne...
GSE103583: RNAseq on WT and Meteor KO Embryonic Stem Cells and day3 differentiated cells
We have demonstrated that Meteor KO cells are associated with a global transcriptional reprogramming...
GSE103194: Reduced Slc1a1 expression is associated with neuroinflammation and impaired sensorimotor gating and cognitive performance in mice: implications for schizophrenia
We characterized the in vivo and in vitro consequences of reduced expression of Slc1a1 in mice. Hete...
GSE106208: Transcriptome profiles of female and male mouse liver
Sexual dimorphism of gene expression is commonly observed in mammalian tissues, including liver. To ...