PLX145765
GSE102903: Neuronal EphB1 induces STAT3 activation in astrocytes, which is impaired in ALS models [Mm]
- Organsim mouse
- Type RNASEQ
- Target gene
- Project ARCHS4
Astrocyte responses to neuronal injury may be beneficial or detrimental to neuronal recovery, but the mechanism that determines these different responses are poorly understood. Transcriptional analysis showed that EphB1 induces a protective inflammatory signature in astrocytes, which is distinct from the response evoked by interleukin (IL)-6, which is known to have both pro- and anti-inflammatory properties. We demonstrate that this beneficial EphB1 induced signaling pathway is disrupted in astrocytes derived from human induced pluripotent stem cells (iPSC) of amyotrophic lateral sclerosis (ALS) patients. SOURCE: Christopher Sibley (c.sibley@imperial.ac.uk) - Imperial College London
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