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Sequencing-based assays (Page 107)
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GSE147836: Gene expression profiling of CLL cells with hyperactivated Notch1 compared to control CLL cells [RNA-seq]
NOTCH1 gain-of-function mutations are recurrent in B cell chronic lymphocytic leukemia (B-CLL), wher...
GSE142710: RNA-seq analysis of the spinal cord cells in scramble microPEP(Scr) or microPEP155(P155) treated EAE mouse model
The goals of this study are to analyze the DEGs of the spinal cord cells in scramble microPEP(Scr) o...
GSE147223: mTORC2/Rac1 pathway predisposes cancer aggressiveness in IDH1-mutated glioma
The present study aims to investigation alterations in the transcriptional profile when cells acquir...
GSE145720: OGT suppresses macrophage proinflammatory activation
Overnutrition leads to metabolic disorders such as obesity and diabetes. Enhanced inflammation has a...
GSE144919: Gene expression in Pou5f1:EGFP-positive spermatogonia from Dazl conditional knockout and control males
RNA-seq of sorted Pou5f1:EGFP-positive spermatogonia from adult testes. SOURCE: Maria,M,MikedisPage ...
GSE147823: Activating PIK3CA mutation promotes osteogenesis of bone marrow mesenchymal stem cells in macrodactyly
Comparison of differential expression between macrodactyly BMSC and polydactyly BMSC SOURCE: Hengqin...
GSE153448: Transciptomic analysis of human aortic smooth muscle cells (HASMCs) with BAF60a knockdown
We used NGS-derived transcriptome profiling (RNA-seq) to compare the transcriptional difference betw...
GSE147905: Expression profiling by high-throughput RNA-sequencing following PGC1 and ERR knockdown in HCT116 cells
The goal of this experiment was to determine differential gene regulation of PGC1 or ERR compared to...
GSE145345: RNA sequencing after HOPX knockdown in human squamous cell carcinoma cell line SCC13
Cutaneous squamous cell carcinomas (cSCC) are frequent heterogeneous tumours, arising from sun-expos...
GSE144381 (mouse): Naproxen Chemoprevention Promotes Immune Activation In Lynch Syndrome Colorectal Mucosa
Lynch syndrome (LS) patients are at markedly increased risk for colorectal cancer. It is being incre...
GSE147850: Genetic signature of prostate cancer mouse models resistant to optimized hK2 targeted alpha-particle therapy
We used RNA sequencing to analyze the genomic signatures of prostate cancer that progressed after ta...
GSE152110: Male mus musculus transcriptomes from whole liver tissue
The ketogenic diet has been successful in promoting weight loss among patients that have struggled w...
GSE147131: Genome wide transcript analysis in Mouse embryonic fibroblasts where endogenous BRD4 is deleted
The goal of this experiment was to find global transcriptional changes upon BRD4 deletion. We report...
GSE144599: An Adaptable Soft-mold Embossing Process for Fabricating Optically-accessible, Microfeature-based Culture Systems and Application toward Liver Stage Antimalarial Compound Testing
Advanced cell culture methods to model organ function have been demonstrated to better replicate in ...
GSE145412: Evaluation of transcriptomic regulations behind metabolic syndrome in obese and lean subjects
The study aimed to investigate molecular signatures in peripheral blood of individuals affected by m...
GSE148019: Gene expression of wild type and tmem182-/- skeletal muscle
Transmembrane proteins are important for intercellular signaling and play important roles in the con...
GSE145712: Gene expression and splicing regulation by hnRNPU in skeletal muscle
Hnrnpu is the largest member of the heterogenous nuclear ribonucleoprotein family of RNA binding pro...
GSE154018: RNA sequencing in E18 whole brains in PAE and SAC mice
These are RNA sequencing data from embryonic day 18 whole brains from embryos whose mother's were ex...
GSE144710: poly A+ RNA sequencing of quiescent and early serum stimulated WI-38s
We performed paired-end poly A+ RNA sequencing using total RNA isolated from serum starved and seru...
GSE144370: PAF1 Drives Pancreatic Cancer Oncogenesis by Promoting Stemness via PHF5A/DDX3 Sub-complex (RNA-seq)
In this study, we established that PAF1 is critical for pancreatic tumorigenesis, and CSC-driven tum...
GSE144595: Surfactant protein A (SP-A) variants and sex-specific regulation of gene expression networks in alveolar macrophages in response to Klebsiella pneumoniae-induced lung infection
Surfactant protein A (SP-A) in addition to its surfactant-related functions interacts with alveolar ...
GSE145428: Reducing metastases stiffness by targeting fibroblasts improves therapeutic outcome in colorectal cancer [Cells]
Analysis of primary fibroblasts isolated from human colorectal primary tumors(CAFs) and liver metast...
GSE145818: Antifibrogenic activities of CYP11A1-derived vitamin D3-hydroxyderivatives are modified by ROR expression
The aim of this study was to test the role of ROR in the action of the above analogs using murine fi...
GSE154074: Gene expression data from bleomycin-instilled lung tissue or control (Sham) of C57BL/6 mice (wild-type mice and transgenic mice expressing dominant-negative form of p38 or constitutive active form of MKK6 in type II alveolar epithelial cells).
Idiopathic pulmonary fibrosis (IPF) is a type of pulmonary fibrosis, a disease that results in scarr...
GSE135406: Comparative transcriptomic and epigenomic analysis identifies key regulators of injury response and neurogenic competence in retinal glia
Injury induces retinal Muller glia of non-mammalian, but not mammalian, vertebrates to generate neur...
GSE144713: Characterizing breast cancer lung metastatic lesions in host environments with or without NK cells by RNA-seq
We demonstrated that natural killer (NK) cells selectively suppress single circulating tumor cells (...
GSE141168: Protein arginine methyltransferase 5 promotes cholesterol biosynthesis mediated Th17 responses and autoimmunity [CD4 T-cells]
Protein Arginine Methyltransferase (PRMT) 5 catalyzes symmetric dimethylation of arginine, a post-tr...
GSE144427: Transcriptome analysis of Chx10-Cre Rb1/p107 and Chx10-Cre Rb1/p107/Hells P21 retinae
We used novel genetically engineered mouse models to investigate the role of HELLS during tumorigene...
GSE148062: H3K27M in Gliomas Causes a One-step Decrease in H3K27 Methylation and Reduced Spreading Within the Constraints of H3K36 Methylation [RNA-seq]
The discovery of H3K27M mutations in pediatric gliomas marked a new chapter in cancer epigenetics. N...
GSE144866: METTL6 is a tRNA m3C methyltransferase that regulates translation and cell proliferation
Here, we identified METTL6 as abona fidetRNA methyltransferase, catalysing the formation of 3-methyl...
GSE145201: RNAseq of B16F10 melanoma CD31+ cells
Intravasation, vascular dissemination and metastasis of malignant tumor cells require their passage ...
GSE137172: RNA-seq analysis CFPAC-1-siNC and CFPAC-1-siUBE2C
The transcriptome sequencing results were used to determine the association between UBE2C and pancre...
GSE144435: Transcriptional comparison of in vitro generated human dendritic cells and peripheral blood circulating dendritic cells.
Classical dendritic cells (cDCs) are rare sentinel cells specialized in the regulation of adaptive i...
GSE155343: Co-cultivation of colorectal cancer cells and human skin fibroblasts in 3D collagen gel and comparison of co-cultivated fibroblasts with CAFs
Despite the growing recognition of the role of the stroma in cancer growth, invasive behavior and me...
GSE144848: Leptomeningeal metastatic cells outcompete macrophages for iron through Lipocalin-2
The tumor microenvironment plays a critical regulatory role in cancer progression, especially in met...
GSE144366: Analysis of RNA-seq of human neuroblastomas from mouse-human neural crest chimeric mice model and in other neuroblastoma models
To confirm the neuroblastomas (NB) identity of human neuroblastomas from mouse-human neural crest c...
GSE145382: RNA-seq of human PBMC's and blood derived macrophages from healthy donors carrying the common (non permissive Treml4 expression) or minor (permissive Treml4 expression) allele for rs2803496 which controls Treml4 expression
Treml4 has been recently characterized as a protein-coding gene of the Trem family. It has been show...
GSE137363: PERICYTE-LIKE CELLS UNDERGO TRANSCRIPTIONAL REPROGRAMMING AND DISTINCT FUNCTIONAL ADAPTATIONS IN ACUTE LUNG INJURY
Background: We previously reported on the role of pericyte-like cells as functional sentinel immune ...
GSE144957: An essential role for MEF2C in the cortical response to loss of sleep
Insight on molecular and cellular responses to sleep loss provides a clearer understanding of sleep ...
GSE135442: RNA sequencing of mouse glomerular endothelial cells and implications of their heterogeneity in Alport syndrome
Background: Recent transcriptomic studies of total glomerular and isolated glomerular endothelial ce...
GSE144817: NIH-3T3 cell line response to proteasome inhibitor
In this study, we compared the transcriptional profile of NIH-3T3 cells that are either wild-type (W...
GSE146726: RNA-Seq of circCDYL knockdown (KD) samples in HepG2, J82, and UMUC3 cells and of GRWD1, IGF2BP1, and IGF2BP2 knockdown (KD) samples in J82 and UMUC3 cells
We profile gene expression upon circCDYL KD in HepG2 cells and in two bladder cancer cell lines J82 ...
GSE144391: ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration
RNA-seq comparing WT and caERBB2 over expresising hearts with/out injury SOURCE: Eldad Tzahor Weizma...
GSE147980: IGF2BP1 is a targetable SRC/MAPK-dependent driver of invasive growth in ovarian cancer
We identified IGF2BP1 as a marker of the C5 molecular subtype of high-grade ovarian carcinoma (HG-SO...
GSE139374: Investigating the role of GLI1 in SULF2-potentiated liver tumorigenesis
The expression of the extracellular sulfatase, SULF2, has been strongly associated with increased he...
GSE154046: Comprehensive analysis of circRNA expression profiles and circRNA associated competing endogenous RNA networks in IgA nephropathy
Purpose: Immunoglobulin A nephropathy (IgAN) is immune-mediated primary glomerulonephritis, which is...
GSE144378: The 3D Genomic Landscape of Differential Response to EGFR/HER2 Inhibition in Endocrine-Resistant Breast Cancer [RNA-seq]
Recent studies suggested that crosstalk between ER and EGFR/HER2 pathways plays a critical role in m...
GSE144956: Homeostatic leukotrienes, IL-25, and IL-33 signals on intestinal ILC2 status
We report the high-throughput profiling of murine intestinal type 2 innate lymphoid cells (ILC2) tra...
GSE154086: Expression profiling in cohesin mutant MCF10A epithelial and CMK leukaemia cells
MCF10A cells were CRISPR-Cas9 edited to create heterozygous deletion in RAD21 and SMC3 subunits of c...
GSE135415: Tissue- and Species-Specific Patterns of RNA metabolism in Post-Mortem Mammalian Retina and Retinal Pigment Epithelium
Accurate analysis of gene expression in human tissues using RNA Sequencing is often dependent on the...
GSE144745: METTL4 catalyzes m6Am methylation in U2 snRNA to regulate pre-mRNA splicing
N6-methylation of 2-O-methyladenosine (Am) in RNA occurs in eukaryotic cells to generate N6,2-O-dime...
GSE144802: Identification of a Novel PP2A Regulator, WNK1, as Critical For Uterine Function
We report the transcriptomic profile of uterine tissues obtained from the control (Wnk1f/f) and Wnk1...
GSE135381: Dietary selenium-methionine affects the levels and toxicity of methylmercury in Balb-C mice
Methylmercury (MeHg) is a well-known neurotoxicant, particularly harmful for the developing brain. S...
GSE154026: Forkhead box a2 (FOXA2) impacts uterine decidualization and fetoplacental development
Forkhead box a2 (FOXA2) is a transcription factor expressed specifically in the glands of the uterus...
GSE144398: RNA sequencing of primary mouse ileal organoids treated with bile acid pools with various compositions
Bile acids act as ligands for several nuclear receptors expressed in the small intestine, especially...
GSE149768: Hypoxanthine phosphoribosyl transferase 1 is upregulated, predicts clinical outcome and controls gene expression in breast cancer
Hypoxanthine phosphoribosyl transferase 1 (HPRT1) is traditionally believed to be a housekeeping gen...
GSE144746: Typical western diet exacerbates dystrophic neurite pathology in APP/PS1 and APP/PS1/Tau mouse models by reducing the clustering of microglia around -amyloid plaques
Here, we studied the interaction between dietary (TWD) and genetic factors (APPswe/PS1dE9 and tau P3...
GSE144948: GSF1635: RNA-seq data of OVCAR3-DAB2IP expressing cells vs. control
Ovarian cancer (OC) is the leading cause of death from gynecologic malignancies in the US. Ovarian c...
GSE147943: Role of CITED2 in shaping macrophage inflammatory response
CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2...
GSE142631: Transcriptomic programming of human CD8+ T cells. By pDCs and cDC2s jin the context of DC-based cancer vaccines
Cancer vaccines utilizing naturally circulating dendritic cell (DC) subsets, such as plasmacutoid DC...
GSE152022: Molecular Signature of Tumor-Infiltrating Regulatory T Cells Reveals IL-33/ST2 Signaling-Mediated Accumulation in the Tumor Microenvironment
Regulatory T cells (Tregs) are enriched in the tumor microenvironment (TME) and suppress anti-tumor ...
GSE144381 (human): Naproxen Chemoprevention Promotes Immune Activation In Lynch Syndrome Colorectal Mucosa
Lynch syndrome (LS) patients are at markedly increased risk for colorectal cancer. It is being incre...
GSE144862: HP1 regulates H3K36 methylation and pluripotency in embryonic stem cells (RNA-seq)
The heterochromatin protein 1 (HP1) family members are canonical effectors and propagators of gene r...
GSE144441: Genome Wide Analysis of Gene Expression Changes in Skin from Patients with Type 2 Diabetes
We investigated genome wide changes in gene expression in skin between patients with type 2 diabetes...
GSE137005: Day-night rhythm in murine retinal pigment epithelium
Murine RPE transcriptomes were generated for 6 time points during a 24 hour period. Our data demonst...
GSE135472: Laboratory mice housed in the natural environment identifies genetic and environmental contributions to immune variation
The relative contribution of genetic and environmental factors to variation in immune response is st...
GSE135457: The landscape of RNA Pol II binding reveals a step-wise transition during ZGA
Zygotic genome activation (ZGA) is the first transcription event in life. However, it is unclear how...
GSE144464: Functional omics analyses reveal only minor effects of microRNAs on human somatic stem cell differentiation [mRNA-Seq]
Functional analysis of transcriptome (mRNA and microRNA) and proteome formation during treatment of ...
GSE145274: Mechanistic basis and efficacy of targeting Beta Catenin-TCF7L2-JMJD6-MYC Axis to overcome resistance to BET inhibitors [OTX015]
Promising activity of BET protein inhibitors (BETis) is compromised by adaptive or innate resistance...
GSE145362: Dlx1/2 mutant and wild type FACS-sorted ENCDCs at P0 and E14.5
These experiments were part of a larger study investigating abnormal bowel motility in mice lacking ...
GSE147893: RNA-sequencing experiments to identify differentially expressed genes between Wild Type and RBM4 KO HAP1 cell line samples
Here, we implemented a computational pipeline to determine the correlation of expression between ind...
GSE137216: CTCF mediates chromatin looping via N-terminal domain-dependent cohesin retention [ChIP-seq & RNA-seq]
The DNA-binding protein CTCF and the cohesin complex function together to shape chromatin architectu...
GSE144648: Pogz deficiency leads to abnormal behavior, transcription dysregulation and impaired cerebellar physiology
As part of characterizing the novel pogz deficiency mouse model, we performed RNA-Seq from cerebellu...
GSE144850: Immunity to commensal skin fungi promotes psoriasiform skin inflammation
Under steady state conditions, the immune system is poised to sense and respond to the microbiota. A...
GSE144978: Determine in vivo the contribution of distal intestinal segments to calcium homeostasis and bone mineralization
To explore this question, we will use three different male mouse models including VDR KO mice and tr...
GSE145175: Men1 and Daxx loss in a mouse model of chronic pancreatitis
Gene expression was evaluated by RNA-seq of mouse pancreas 5 days following chronic caerulein-induce...
GSE145349: CRISPR repair in a preclinical model of Noonan syndrome associated cardiomyopathy II
We profiled RNA expression in human iPSC-derived cardiomyocytes from patients with LZTR1-associated ...
GSE154048: The cellular basis of distinct thirst modalities
We performed single-cell RNA-seq (10x Chromium 3' v.2) on dissociated single cell suspensions from m...
GSE135394: Tandem CTCF sites function as insulators to balance spatial chromatin contacts and topological enhancer-promoter selection [I]
CTCF is a key insulator-binding protein and mammalian genomes contain numerous CTCF-binding sites (C...
GSE147844: Chromatin accessibility and transcriptome changes in injured retinal ganglion cells (RGCs) after Arid1a deletion
To gain a deeper insight into roles of Arid1a in injured retinal ganglion cells (RGCs), we performed...
GSE144887: EphrinB1 Modulates Glutamatergic Inputs into POMC Neurons and Controls Glucose Homeostasis
We aim at identifying genes enriched in POMC neurons versus NPY neurons that were involved in glutam...
GSE144990: High throughput phenotypic screen and transcriptional analysis identify new compounds, targets and pathways for macrophage reprogramming II
Purpose: To understand compound effects on human macrophage repolarization in the transcriptional le...
GSE145095: A transcriptomic atlas of murine and human alopecia areata identifies immune cell profiles predictive of human disease state.
Alopecia areata (AA) is one of the most common autoimmune conditions, presenting initially with loss...
GSE136628: Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis
Development of effective therapies against brain metastasis is currently hindered by limitations in ...
GSE146785: Immunoresolving lipid mediators support effective skeletal muscle repair
Specialized pro-resolving mediators (SPMs) function to limit inflammation and actively stimulate SOU...
GSE147868: In vivo RNA-seq for for Hh Dependent genes in E7.5 mesoderm
Mesp1-Cre+ cells from E7.5 mouse embryos (from the cross Mesp1-Cre/+ x Rosa26-Gli3R-IRES-YFP/tdTo...
GSE138941: Intravital imaging identifies long-term self-renewing stem cells in the adult mouse hippocampus
Neural stem cells (NSCs) generate new neurons throughout life in the mammalian hippocampus. However,...
GSE146832: Transcriptional profiling of mouse pancreatic tumor cells I
RNA-seq analysis of sorted WT and Klf5/Smad4/Egfr-KO 6694c2 mouse pancreatic tumor cells from subcut...
GSE144913: BX795 small inhibitor of TBK1 effect on mouse fibroblast cell line that transfected with pEGFP-N1 plasmid
AbstractDNA transfection is widely used in biomedical research. However, transfection efficiency is ...
GSE145204: Transcriptional responses to TNF following HFl treatment of primary rheumatoid arthritis fibroblast like synoviocytes (RA-FLS)
We report the effects of Hfol on TNF induction of inflammatory genes in wild type cells versus cells...
GSE145450: The long non-coding RNA LUCAT1 is a negative feedback regulator of the Interferon Response in humans (LPS dataset)
Long non-coding RNAs (lncRNAs) are important regulators of biological processes including immune res...
GSE137227: miR-302 is a temporal regulator of neural crest development [Mouse RNA-seq]
We analyzed wildtype and miR-302 knockout embryos at E7.5 and sorted neural crest using Wnt1-Cre at ...
GSE143423: Single-Cell Map of Diverse Immune Phenotypes in the Metastatic Brain Tumor Microenvironment of Non Small Cell Lung Cancer and triple negative breast cancer
To shed light on the complexity of tumor-infiltrating immune cells in non-small cell lung cancer (NS...
GSE147815: Transcriptomic maps of pharmacological LSD1 inhibition in MCC [QUANTseq]
Merkel cell carcinoma (MCC) is a highly aggressive, neuroendocrine skin cancer that lacks actionable...
GSE137409: Crosstalk between eIF2 and eEF2 phosphorylation pathways optimizes translational arrest in response to oxidative stress
The cellular stress response triggers a cascade of events leading to transcriptional reprogramming a...
GSE147855: To study the function of KLF5 in squamous cancers and gastrointestinal cancers [RNA-seq]
To identify KLF5 target genes and study the gene regulation function of KLF5 by integrating ChIP-seq...
GSE144959: Sequencing of mRNA in AML cells upon ALKBH5 knockdown and actinomycin D treatment for different time
To evaluate the effects of ALKBH5 KD on the mRNA stability, we conducted RNA-seq of mRNA samples enr...
GSE145210: Transcriptome network analysis of Smug1 knock-out cells by using CRISPR/Cas9 system
Purpose: To build a differential transcriptome network in Smug1 knock-out HepG2 hepatocarcinoma cell...
GSE141192: GM-CSF controls Mycobacterium tuberculosis infection by limiting type I IFN-driven neutrophil extracellular trap formation [Blood]
Tuberculosis (TB) remains the worlds top infectious killer. Understanding how immune mediators deter...
GSE144759: Synergistic Targeting of FLT3 Mutations in AML via Combined Menin-MLL and FLT3 Inhibition
The interaction of Menin (MEN1) and MLL (MLL1, KMT2A) is a dependency and potential therapeutic oppo...