PLX005320

GSE144948: GSF1635: RNA-seq data of OVCAR3-DAB2IP expressing cells vs. control

Organsim human
Type RNASEQ
Target gene
Project ARCHS4

Ovarian cancer (OC) is the leading cause of death from gynecologic malignancies in the US. Ovarian cancer stem cells (OCSCs) have been shown to drive chemoresistance and tumor progression but the mechanism remains incompletely understood. Disabled Homolog 2- Interacting Protein (DAB2IP) is a potent tumor suppressor identified in multiple types of cancers and we demonstrate that DAB2IP is silenced by the repressive epigenetic mark H3K27me3 at the DAB2IP promoter loci in OCSCs. SOURCE: Kenneth Nephew (knephew@indiana.edu) - Indiana University

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