PLX035273

GSE147943: Role of CITED2 in shaping macrophage inflammatory response

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2) is a member of the CITED family of proteins that play very critical roles in cellular development and differentiation. Several independent studies have revealed that mutation in the CITED2 gene is associated with human congenital heart defects. Concordant with these observations, experimental murine studies affirmed that mutation or loss of Cited2 resulted in congenital heart defects, as well as perturbation in the left-right patterning of the body axis. Furthermore, deficiency of Cited2 significantly impaired the development of lung, liver, placenta, and adrenal tissue at the embryonic stage (PMCID: PMC5809687). SOURCE: Ernest,R,Chan (erc6@case.edu) - CWRU

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