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Sequencing-based assays (Page 55)
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GSE99457: Injury-inducible stem cell potential of the intestinal enteroendocrine lineage: single-cell mRNA-seq profiling
We report the single-cell transcriptomic profiles of Bmi1-GFP+ and Prox1-GFP+ cells in comparison to...
GSE101423: Clock-dependent chromatin topology modulates circadian transcription and behavior
The circadian clock dynamically rewires promoter-enhancer loops in tissues to drive robust daily rhy...
GSE100328: KMT2C medaites the estrogen dependence of breast cancer through regulation of ER enhancer function
KMT2C is a key regulator of ER activity whose loss allows for hormone independent proliferation in M...
GSE92344: Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors
Loss of function mutations of the histone acetyltransferase CREBBP have recently been described at h...
GSE101396: Next generation sequencing of human monocyte derived dendritic cells stimulated for two hours with LPS, C5a and/or MSK inhibitor SB-747561
In order to determine the full breath of C5aR and TLR crosstalk in human DC, RNA sequencing analysis...
GSE101496: Triggering of NOD2 receptor converts inflammatory Ly6Chigh into Ly6Clow monocytes with patrolling properties.
In the present study, we demonstrate that NOD2 receptor triggering by muramyl dipeptide converts blo...
GSE102629: Dietary effect on mouse intestinal Lgr5 stem cells
Dietary effect on mouse intestinal Lgr5 stem cells SOURCE: Wenge Li (wenge.li@einstein.yu.edu) - Aug...
GSE110041: In-vitro stimulation of healthy donor blood with IL-3 cytokine
This experiment was designed to look for in vitro IL-3 gene signature in donor blood at two differen...
GSE99992: Whole blood RNA-seq of pediatric cases of natural Chikungunya infection
The primary aim of this study was to characterize the transcriptomic changes between the acute and c...
GSE101391: RNA-Seq analysis of sorted cortical projection neuron subtype specific responses in a mouse model of ALS over the course of disease progression
Neocortical hyperexcitability is a prominent feature of inherited and sporadic amyotrophic lateral s...
GSE101316: Expression data from WT and Ezh2-deficient macrophages non-treated (NT) or stimulated for 2 h with LPS
we conducted gene expression profile analysis by using WT and Ezh2-deficient bone marrow-derived mac...
GSE99202: YAP Repression of the WNT3 Gene Controls hESC Differentiation Along the Cardiac Mesoderm Lineage
In hESCs, Wnt3/-catenin activity is low and Activin/SMAD signaling ensures NANOG expression to susta...
GSE106229: Gene expression changes upon activation of RIG-I by a minimal potent RIG-I ligand
We have developed highly potent synthetic activators of the vertebrate immune system that specifical...
GSE104872: mRNA-seq in MCF7 cells in response to 4-hydroxytamoxifen (OHT)
Purpose: Study the temporal effect of OHT on gene expression in MCF7 cells using mRNA-seq.; Methods:...
GSE90815: Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP pathways in macrophages
Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol transpor...
GSE90755: Transcriptome profiling of wildtype C57BL/6 mouse with metformin treatment
Background: Metformin, one of the first-line medication for the treatment of type 2 diabetes and ges...
GSE99839 (human): Inhibitors of the histone methyltransferases EZH2/1 induce a potent antiviral state and suppress infection by diverse viral pathogens [RNA-Seq]
Epigenetic regulation is based upon a network of complexes that modulate the chromatin character and...
GSE90809: A neural basis for melanocortin-4 receptor-regulated appetite.
Pro-opiomelanocortin (POMC)- and agouti-related peptide (AgRP)-expressing neurons of the arcuate nuc...
GSE100441: Integrated Transcriptomic and Proteomic Dynamics of Rituximab Treatment in Primary B Cells
The investigation aims to profile the molecular dynamics of Rituximab treatment in cells. Specifica...
GSE101527: Reversing SKISMAD4-mediated suppression is essential for TH17 cell differentiation
Disruption of Ski/Smad4 license Th17 differentiation. TGF-b-Ski-Smad4-RORgt-Th17 axis SOURCE: Yisong...
GSE95251: Genomic responses of mouse synovial fibroblasts during TNF-driven arthritogenesis greatly mimic those of human rheumatoid arthritis (RNA-Seq).
We used deep sequencing to probe the transcriptome, the methylome and the chromatin landscape of cul...
GSE112304: Comparison of young and aged mouse CD8 TN, TVM and TMEM cells directly ex vivo and after polyclonal stimulation
The overall study (Quinn et al. Cell Reports, 2018) aimed to understand why CD8 virtual memory T (TV...
GSE99480: Role of SWEF proteins in ABC differentiation
Age/autoimmune-associated B cells (ABCs) are a T-bet dependent B cell subset, which accumulates prem...
GSE101769: Epigenetic reprogramming enables the primordial germ cell-to-gonocyte transition (RNA-Seq)
Gametes are highly specialised cells that can give rise to the next generation through their ability...
GSE106340: Optimal-transport analysis of single-cell gene expression identifies developmental trajectories in reprogramming I
We collected single or duplicate samples at the various time points, generated single cell suspensio...
GSE113106: RNA sequencing of control and dnm2-knockout mouse sciatic nerves
In this study, we analyzed the transcriptome profiles of mouse sciatic nerves after developmental (P...
GSE94136: Bone Morphogenetic Protein and Retinoic Acid Synergistically Specify Female Germ Cell Fate in Mice
The mechanism for sex determination in mammalian germ cells remains unclear. Here, we reconstitute t...
GSE101799: Transcriptomic analysis to underly the heterogeneity between 4 cellular models derived from patients diagnosed with pediatric high-grade gliomas under controlled atmosphere (modulation of oxygen level).
Generation of preclinical models which recapitulate at best the extreme intra-tumoral heterogeneity ...
GSE96700: The Stability of the Transcriptome during the Estrous Cycle in Four Regions of the Mouse Brain
We analyzed the transcriptome of the C57BL/6J mouse hypothalamus, hippocampus, neocortex, and cerebe...
GSE106330: Degree of Tissue Differentiation Dictates Susceptibility to BRAF-driven Colorectal Cancer
In murine models, we find that oncogenic BRAF paradoxically suppresses stem cell renewal and instead...
GSE102956: APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types
The apolipoprotein E4 (APOE4) variant is the single greatest genetic risk factor for sporadic Alzhei...
GSE108454: WNT ligands control initiation and progression of human papilloma-virus-driven squamous cell carcinoma
Human papilloma virus (HPV)-driven cutaneous squamous cell carcinoma (cSCC) is the most common cance...
GSE94087: Obesity Alters the Composition and the Activity of the Hematopoietic Stem Cell Compartment Through Dysregulation of Gfi1 Expression (single-cell RNA-Seq)
Obesity is a chronic organismal stress that disrupts multiple systemic and tissue-specific functions...
GSE90905: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program
Systemic metabolic alterations associated with increased consumption of saturated fat and obesity ar...
GSE102204: Transcriptome and translatome profiling from brains of a mouse model of severe SMA
Spinal muscular atrophy (SMA) is the most common genetic cause of infant mortality, with an incidenc...
GSE100421: Transcriptomic analysis of neuroepithelium and sorted neural progenitors in the murine cortex duirng early stages of development
Relatively little is known about how the identity of early neuronal stem cells changes before and af...
GSE102116: Novel Form of JARID2 is Required to Regulate Differentiation in Keratinocytes.
Polycomb repressive complex-2 (PRC2) is a group of proteins that play important role during developm...
GSE90854: Acetyl CoA metabolism by ACSS2 regulates neuronal histone acetylation and hippocampal memory [RNA-seq In Vitro]
Metabolic production of acetyl-CoA has been linked to histone acetylation and gene regulation, howev...
GSE102556 (mouse): Sex-specific Transcriptional Signatures in Human Depression
Rational: Major depressive disorder (MDD) is a leading cause of disease burden worldwide. While the ...
GSE90921: The Glycogen Synthase Kinase-3 Phosphoproteome: GSK-3 Phosphorylates Multiple Splicing Factors and Regulates Alternative Splicing
Glycogen Synthase Kinase-3 (GSK-3) is a constitutively active, ubiquitously expressed protein kinase...
GSE90937: Repression by PRDM13 is critical for generating precise neuronal identity (RNA-Seq)
The mechanisms that activate some genes while silencing others are critical to ensure precision in l...
GSE143304: Genome wide anaylsis of transcriptome modifications in male mice exposed to tributyltin during development
Purpose: To identify alterations induced by developmental exposure to tributyltin at different stage...
GSE90932: FTY720 (fingolimod) regulates key target genes essential for inflammation in microglial cells
Although microglial have an essential role in host defense in the brain, the abnormal activation of ...
GSE101868 (mouse): Catalogue of differentially expressed long non-coding RNAs following activation of human and mouse innate immunity
Despite increasing evidence to indicate that long non-coding RNAs (lncRNAs) are novel regulators of ...
GSE117557: RNA sequencing of mouse epidermis and papillomas treated with 20% camphor white oil or acetone vehicle
Camphor white oil (CWO) application was found to induce regression of papillomas in a mouse chemical...
GSE118201: Gene expression comparison of exhausted CD8 T cells that respond or do not respond to PD-1 blockade
CD8 T cells that respond to PD-1 blockade (during the early stage of infection) have enriched CD28 c...
GSE102556 (human): Sex-specific Transcriptional Signatures in Human Depression
Rational: Major depressive disorder (MDD) is a leading cause of disease burden worldwide. While the ...
GSE136679: Functional Compensation Precedes Recovery of Tissue Mass Following Acute Liver Injury
We identify a new phase of functional compensation following acute liver injury that occurs prior to...
GSE109899: Facultative dosage compensation of developmental genes on autosomes in Drosophila and mammals [RNA-seq mouse]
Haploinsufficiency and aneuploidy are two phenomena, where alteration of gene dosage causes severe c...
GSE101872: RNA Missplicing in Fuchs Endothelial Corneal Dystrophy
RNA-Seq splicing data from the corneal endothelia of FECD patients and controls reveal hundreds of d...
GSE102269: Mitochondrial unfolded protein response gene Clpp plays a role in female fertility and reproductive aging
We performed RNAseq analysis to determine the effect of ClpP-deletion on cumulus cells global gene e...
GSE110035: Antiretroviral therapy potentiates high-fat diet induced obesity and glucose intolerance
Background Breakthroughs in HIV treatment, especially antiretroviral therapy (ART), have massively r...
GSE100322: Whole transcriptome sequencing of the human thyroid primary cells with knock-down of the NRG1 gene
The protein encoded by the NRG1 gene is a membrane glycoprotein that mediates cell-cell signaling an...
GSE102611: RNA-seq analysis in the Tas2r143-reporter mice (Tas2r143-CreERT2;Rosa26flox-mT-stop-flox-mG)
RNA-seq analysis of Tas2r143-expressing cells in the trachea and stomach of adult Tas2r143-reporter ...
GSE129961: Analysis of lncRNAs in macrophages
We identified long noncoding RNAs (lncRNAs) expressed in macrophages and characterized one lncRNA, d...
GSE90977: Altered Ca+2 homeostasis induces Calpain-Cathepsin axis activation in sCJD.
Sporadic Creutzfeldt-Jakob disease (sCJD) is the most prevalent form of human prion disease and it i...
GSE103270: Transcriptional profile in dermal fibroblasts from patients with collagen VI related muscular dystrophy
Objectives: The collagen VI related muscular dystrophies (COL6-RD), Ullrich congenital muscular dys...
GSE103531: SILAC identifies LAD1 as an oncogenic filamin binder regulating actin dynamics in response to EGF and marking aggressive breast tumors
Mutations mimicking growth factor-induced proliferation and motility characterize some aggressive su...
GSE118279: Unr is a potential post-transcriptional master regulator of protein expression
Ribonucleoprotein immunoprecipitation followed by mass spectrometry and RNA-Seq was used to investig...
GSE110054: Transcriptional responses of melanoma cells to BRAF inhibition
We performed a time-course experiment to determine the temporal transcriptional changes that occur i...
GSE102048: Profiling proliferative cells and their progeny in damaged murine hearts
The significance of cardiac stem cell (CSC) populations for cardiac regeneration remains disputed. H...
GSE94085: SMYD5 regulates H4K20me3-marked heterochromatin to safeguard ES cell self-renewal and prevent spurious differentiation [RNA-Seq]
Epigenetic regulation of chromatin states is thought to control the self-renewal and differentiation...
GSE107115: Subcellular genomics shows pervasive within-mitochondrion single nucleotide variant heteroplasmy as revealed by single mitochondrion sequencing
We performed single cell RNA-seq on the cell somas of mouse neurons and astrocytes. The transcriptom...
GSE106989: Investigate A2M treatment on human prostate cancer xenograft in mice
Cancer resistance is a major cause for longevity of the naked mole-rat. Recent liver transcriptome a...
GSE135875: Temporal profiles of hepatic gene expression in PAR bZip triple knockout mice
The circadian clock and rhythmic food intake are both important regulators of rhythmic gene expressi...
GSE106394: Hsa-miR-371a-5p and hsa-miR-518a-3p regulated genes in choriocarcinoma cells
We report the application of transcriptome sequencing for investigating of the hsa-miR-371a-5p and h...
GSE134056: Machine Learning Classifiers for Endometriosis Using Transcriptomics and Methylomics Data [Transcriptomics]
We experimented how well various supervised machine learning methods such as decision tree, partial ...
GSE95687: The eutherian-specific miR-290/miR-371 cluster modulates placental growth and maternal-fetal transport
A family of vertebrate-specific microRNAs called the ESCC microRNAs regulates proliferation and diff...
GSE102270: RNA-seq analysis of gene expression profile in Uhrf1 WT and KO germinal center B cells
The goals of this study are to compare gene expression profiles of Uhrf1 WT and KO germinal center B...
GSE104112: Validation of AS1 as novel regulator of tumor resistance to immune cell attack
The experiment was performed to verify wether knockdown of AS1 in combination with TNFa treatment af...
GSE109797: Ang II type 1a receptor in Marfan syndrome
Using Cdh5-Cre and Sm22-Cre transgenes to characterize the impact of disruption of the angiotensin I...
GSE100635: Histamine H3 receptor agonist regulates the expression of inflammation-related genes in kidney and heart of ANS-treated mice
We found the impaired renal function accompanied with severe cardiac dysfunction in mice co-treated ...
GSE107176: Polycomb complexes associate with enhancers to promote oncogenic transcriptional programs in cancer
The Polycomb repressive complexes PRC1 and PRC2 play an essential role in cell fate decisions, embry...
GSE93735: Anti-inflammatory Chromatinscape Associated with Clinically Relevant Timing of Glucocorticoid Treatment [RNA-Seq]
Despite the widespread use of glucocorticoids (GCs) for treating inflammatory conditions, the underl...
GSE107184: The role of KLF7 in pancreatic adenocarcinoma (PDAC) progression
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a dismal prognosis. Currently, ...
GSE103029: TAp73 is a marker of glutamine addiction in medulloblastoma
Metabolically-targeted therapies hold the promise of offering an effective and less toxic treatment ...
GSE102114: Differential expression of long noncoding RNA and mRNA in children with HenochSchnlein purpura nephritis
Long noncoding RNAs (lncRNAs) serve an essential role in regulating immunological functions. However...
GSE119012: Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and FXRalpha-/- testicular Transcriptomes with Environmental Exposure
The goals of this study are to define the putatitve impacts of FXRalpha deficiency in testicular phy...
GSE102908: RNAseq data from SCCOHT1 and OVCAR8 ovarian cancer cells treated with BET inhibitors
The antitumor activity of bromodomain inhibitors (BETi) has been demonstrated across numerous types ...
GSE104157: Single-cell RNA-seq (Smart-seq2) of MGE of E13.5 mice
Single-cell RNA-seq of mitotically enriched cells in the medial ganglionic eminence (Dlx6 negative),...
GSE90988: An intrinsic transcriptional program underlying synaptic scaling during activity suppression
Homeostatic scaling allows neurons to maintain stable activity patterns by globally altering their s...
GSE91015: Crispr-Cas9-mediated Aire gene editing in medullary thymic epithelial (mTEC) cells shows its role as a gene expression modulator during thymocyte adhesion
The aim of this study is to evaluate the effect of Autoimmune regulator (Aire) gene disruption in a ...
GSE95337: Innate versus adaptive lymphoid cell fate choice is controlled by the E-Id protein axis [RNA-Seq]
The lymphoid branch of the immune defense is composed of innate and adaptive immune cells. Using mul...
GSE101883: Cerebellar gene expression in 6-Cre Crfr1 knock-out mice
Corticotropin-releasing factor (CRF) and its type 1 receptor (CRFR1) play an important role in the b...
GSE103000: Impact of B16F0 exosomes on the transcriptome of CTLL2 cytotoxic T cells
While recent clinical studies demonstrate the promise of cancer immunotherapy, a barrier for broaden...
GSE94089: DNA methylation regulates nephron progenitor cell renewal and differentiation
Nephron number is a major determinant of long-term renal function. We hypothesized a link between ep...
GSE64399: Human Schlafen 5 (SLFN5) is a Regulator of Motility and Invasiveness of Renal Cell Carcinoma (RCC) Cells
There is some emerging evidence that members of the Schlafen (SLFN) family of proteins mediate anti...
GSE102721: Mechanistic differences in neuropathic pain modalities revealed by correlating behavior with global expression profiling (RNA-Seq)
Chronic neuropathic pain is a major morbidity of neural injury, yet its mechanisms are incompletely ...
GSE110105: RNA-seq analysis of gene expression patterns of cells from stem-cell-derived-synthetic-embryos, named as 'ETX-embryos'.
We analyze the difference between ETX-side1 cells and ETX-side2 cells. Side1 cells are associated wi...
GSE102131: Genome wide expression analysis of young and aged human endometrium
We use RNA-sequencing to measure global transcription in LH timed endometrial biopsies of 10 women a...
GSE94949: Myocardial infarction (MI) primes autoreactive T cells through activation of dendritic cells
DC subsets of the murine healthy heart consisted of IRF8-dependent conventional (c)DC1, IRF4-depend...
GSE95448: Single cell RNA-seq of 312 basal epithelial cells from the mammary glands of pregnant and adult mice
Mammary glands were collected from 8 pregnant (12.5 day) mice and 8 adult (10 week old) female mice....
GSE98671: Targeted degradation of CTCF decouples local insulation of chromosome domains from genomic compartmentalization
The molecular mechanisms underlying folding of mammalian chromosomes remain poorly understood. The t...
GSE102132: KSHV vIRF3 promotes angiogenesis of lymphatic endothelial cells (LECs)
Herein, we report viral interferon regulatory factor 3 (vIRF3) as a pro-angiogenic factor together w...
GSE105026: Gene Regulation by Histone Deacetylase 7 During Invariant Natural Killer T Cell Development
We have found that the signal-dependent chromatin modulator Histone Deacetylase 7 interacts with and...
GSE96057: Ablation of the stress protease OMA1 protects against heart failure
Heart failure (HF) is a major health and economic burden in developed countries. It has been propose...
GSE117596: PRMT5 knockdown changes gene expression in prostate cancer cells
PRMT5 is the major type II protein arginine methyltransferase catalyzing the symmetric dimethylation...
GSE102107: HIF and HOIL-1L-mediated PKC degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury
Exposure to hypoxia requires adaptive mechanisms for survival. During acute hypoxia, Na,K-ATPase end...
GSE91387: Microglial-specific transcriptome changes following chronic alcohol consumption
Microglia are fundamentally important immune cells within the central nervous system (CNS) that resp...
GSE103983: Single-cell RNA-seq (Drop-seq) of MGE, CGE and LGE of E13.5 (MGE) and E14.5 (CGE, LGE) mouse embryos
Single-cell RNA-seq to profile a developmental time course of interneuron development, measuring the...