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Sequencing-based assays (Page 114)
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GSE149632: Phenotypic manifestation of alpha-synuclein strains from Parkinsons disease and multiple system atrophy in human dopaminergic neruons
Although -synucleinis implicated in the pathogenesis of Parkinsons disease and related disorders, it...
GSE152281: Single cell profiling shows that murine forebrain neural stem cells reacquire a developing precursor state when activated to make adult-born neurons
In this study, we have utilized a single-cell RNA-Sequencing platform coupled with transgenic lineag...
GSE151406: Transforming Growth Factor-b Suppresses Type 2 Immunity to Cancer
The immune system employs two distinct defense strategies against infections: pathogen elimination t...
GSE144233: RNAseq comparison of Whole crypt mRNA levels between Control, conditional Notchless KO, Apc KO and Notchless-Apc KO mice 24h or 48h after induction
Control (Villin-CreERT2tg/0; Apcflox/+; Nleflox/+), ApccKO (Villin-CreERT2tg/0; Apcflox/flox; Nleflo...
GSE149609: Multi-omics analysis reveals divergent epigenetic regulation of gene expression and drivers of esophageal squamous cell carcinoma (RNA-Seq)
Purpose: Epigenetic landscapes can shape physiologic and disease phenotypes. We used whole genome bi...
GSE150521: -catenin drives distinct transcriptional networks in proliferative and non-proliferative cardiomyocytes
The inability of the adult mammalian heart to regenerate represents a fundamental barrier in heart f...
GSE150672: Highly Efficient, Massively-Parallel Single-Cell RNA-Seq Reveals Cellular States and Molecular Features of Human Skin Pathology
The development of high-throughput single-cell RNA-sequencing (scRNA-Seq) methodologies has empowere...
GSE148538: Cabozantinib Can Block Tumor Growth by Disrupting Tumor Vasculature in Neuroendocrine Prostate Cancer Patient-Derived Xenografts
With the advent of potent second-line anti-androgen therapy, we and others have observed an increase...
GSE140061: The T-box Transcription Factor Eomesodermin Governs Hemogenic Competence of Yolk Sac Mesodermal Progenitors [scRNA-Seq]
Extra-embryonic mesoderm (ExM), the earliest cells that traverse through the primitive streak, give ...
GSE149623: RNA-Seq is used to facilitate the identification of the BCR-ABL1- independent mechanism of resitance to imatinib using a human chronic myeloid leukaemia cell line model
The goals of this study were to compare two human chronic myeloid leukaemia cell lines. One is sensi...
GSE142325: Comparison of multiple passages of VEEV V4020 to VEEV TC-83 at 2 days after intracranial inoculation in BALB/c mice
Experimental V4020 is derived from VEEV TC-83, a vaccine with a long track record of use in lab and ...
GSE142341: Mouse models of neutropenia reveal progenitor-stage-specific defects [CITE-Seq]
Advances in genetics and sequencing have lead to a deluge of disease-associated and disease-causing ...
GSE149627: Genome-wide maps of chromatin state in folate deficiency mESCs
Folate deficiency causes widespread DNA breakages and is responsible for neural tube defect (NTD). H...
GSE154978: Emergence of a high-plasticity cell state during lung cancer evolution, single-cell RNAseq tigit
Tumor evolution from a single cell into a malignant, heterogeneous tissue remains poorly understood....
GSE151484: Soluble RARRES1 induces podocyte apoptosis to promote glomerular disease progression
We try to explore the effect of RARRES1 on human podocyte, so we performed RARRES1 overexpression an...
GSE148803 (human): Gene expression regulation by the Chromodomain Helicase DNA-binding protein 9 (CHD9) chromatin remodeler is dispensable for murine development
Purpose: Chromodomain helicase DNA-binding (CHD) chromatin remodelers regulate transcription and DNA...
GSE146265: Antigen-specific memory and nave CD4+ T cells following secondary Chlamydia trachomatis infection
Memory antigen-specific CD4+ T cells against Chlamydia trachomatis are necessary for protection agai...
GSE151512: RNA-seq of CBD-treated SK-N-BE(2) cells over a time course of 3hr - 24hr with vehicle (ethanol) matched controls at each time point.
Cannabidiol (CBD) is an FDA approved drug for treatment of drug-intractable forms of pediatric epile...
GSE149616: NAD+ regeneration rescues lifespan but not ataxia in a mouse model of brain mitochondrial complex I dysfunction
Mitochondrial complex I regenerates NAD+ and proton pumps for TCA cycle function and ATP production,...
GSE146257: TAp63-regulated microRNAs suppress cutaneous squamous cell carcinoma [RNA-seq]
The goal of this study is to compare the differences in the global mRNA expression of WT and TAp63-/...
GSE151491: A SIX1/EYA2 small molecule inhibitor disrupts EMT and metastasis
This study identified a novel compound reverses SIX1-mediated EMT and metastasis in breast cancer SO...
GSE146285: Single-cell transcriptomics during different phases post cardiac ischemia reveals secreted B2M to regulate fibroblast activation
The efficiency of the repair process following ischemic cardiac injury is a crucial determinant for ...
GSE153369: Phagocytosis-related NADPH oxidase 2 subunit gp91phox contributes to neurodegeneration after repeated systemic challenge with lipopolysaccharides
Here, we investigated the role of mononuclear phagocytes associated nicotinamide adenine dinucleotid...
GSE141471: The Human Accelerated Region HACNS1 modifies developmental gene expression in humanized mice
Understanding how uniquely human genetic changes altered developmental processes is essential to und...
GSE155027: Near-infrared-emitting nanoparticles activate collagen synthesis via TGF signaling
We describe the novel synthesis Ag2S nanoparticles (NPs) by using a sonochemical method and reveal t...
GSE151494: Neuropilin-1(NRP1) is a T cell memory checkpoint limiting long-term anti-tumor immunity
Transcriptomic analysis of NRP1 KO and WT donor pMel-T cells recovered from B16-gp100 tumors SOURCE:...
GSE149124: RNAseq for CDK7 brown adipose tissue specific knockout mice under room temperature and 6 hrs cold exposure.
Purpose: The goal of this study are to compare global gene expression profile in brown adipose tiss...
GSE149634: Single cell mapping of breast tumor stroma reveals dynamically evolving compositions of cancer-associated fibroblasts along tumor progression (bulk RNA-seq dataset)
Tumors are complex ecosystems, in which malignant and non-malignant cells engage in continuous inter...
GSE146254: Comparative RNA-Seq transcriptome analyses reveal dynamic time dependent effects of 56Fe, 16O, and 28Si irradiation on the induction of murine hepatocellular carcinoma
One of the health risks posed to astronauts during deep space flights is exposure to high charge, hi...
GSE153431: Truncation of Pik3r1 Causes Severe Insulin Resistance Uncoupled From Obesity and Dyslipidaemia by Increased Energy Expenditure
Both PIK3R1(Y657X) mutant and wild-type C57Bl/6J mice were maintained on chow until 16 weeks old, at...
GSE140091: The T-box Transcription Factor Eomesodermin Governs Hemogenic Competence of Yolk Sac Mesodermal Progenitors [RNA-Seq]
Extra-embryonic mesoderm (ExM), the earliest cells that traverse through the primitive streak, give ...
GSE141961: Polycomb-mediated repression of EphrinA5 promotes growth and invasion of glioblastoma
Glioblastoma (GBM) is the most common and most aggressive intrinsic brain tumour in adults. Integrat...
GSE141593: Gene expression profile of wild type, PiZ and PiZ/Chop-/- mouse livers at two different ages
To investigate the role of CHOP in the pathogenesis of liver disease due to Z alpha-1 antitrypsin in...
GSE150924: YBX1 indirectly targets heterochromatin-repressed inflammatory response genes through binding to CBX5 [RNA-Seq]
The RNA- and DNA-binding protein YBX1 is involved in various cellular processes. We here focused on ...
GSE150990: Rhes, a striatal enriched protein, regulates SUMOylation of nuclear proteins and gene expression in a SUMO-dependent manner
Rhes, a multifunctional striatal protein, regulates nuclear proteins and gene expression via SUMO-me...
GSE148301: Identification of Hepatic Genes Regulated by ATF3 using Next Generation Sequencing
This study aimed to investigate how many genes were regulated by hepatocyte ATF3. C57BL/6J mice were...
GSE152553: Skeletal muscle RNA expression following implantation of LLC1 cells in mice
7- week old male and female, C57BL6 mice received subcutaneous injections of LLC1 lung adenocarcino...
GSE140192: Comparative profiling of metastatic 4T1- versus non-metastatic Py230-based mammary tumors in an intraductal model for triple-negative breast cancer.
Purpose: Compare the tumor outgrowth and immunology of an immunocompetent 4T1- and Py230-based intra...
GSE153287: Transcriptional changes induced by miR-21 antagonism in T helper cells abrogates Th17 tumor promoting functions
Multiple myeloma (MM) is a hematologic malignancy tightly dependent on inflammatory bone marrow micr...
GSE151029: Comparative transcriptomic analysis of WT, FOXK1/2 KO, DKO cells and FOXK1 KO cells with reconstitution of several FOXK1 mutants
The goal of this study was to apply Next Generation Sequencing analyses to identify genes and pathwa...
GSE140222: Endometrial Axin2+ cells drive epithelial homeostasis and regeneration, and develop endometrial cancer following oncogenic transformation
Summary: RNAseq analysis of Axin2+ and Axin2- endometrial epithelial cells shows that Axin2+ cells h...
GSE149690: Gene expression for circFAM120A knockdown by RfxCas13d/BSJ-gRNA or shRNA in human 293FT cells
Deep sequencing datasets are used for gene expression analysis. Knockdown of circFAM120A by BSJ-gRNA...
GSE151480: Monocyte Subsets with High Osteoclastogenic Potential and Their Epigenetic Regulation Orchestrated by IRF8 [RNA-Seq sorted cells]
Currently, it is unclear if all monocyte subsets exhibit osteoclastogenic potential. Furthermore, th...
GSE150510: Combining multi-omics and drug perutbation profiles to identify novel treatments that improve disease phenotypes in spinal muscular atrophy [RNA-seq]
We used an in-depth and parallel approach combining proteomics, transcriptomics and the drug pertuba...
GSE140259: Distinct signaling and transcriptional pathways regulate peri-weaning development and cold-induced recruitment of beige adipocytes
Adipose tissue provides a defense against starvation and environmental cold. These dichotomous funct...
GSE149646: Ascending dorsal column sensory neurons respond to spinal cord injury and downregulate genes related to lipid metabolism
The goal of this study was to compare the transcriptional effects of sciatic nerve injury and spinal...
GSE132398: Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability [ RNA-seq]
Connections between RNA polymerase II (RNAPII) transcription stress, R-loops, and genome instability...
GSE151810: RNA sequencing analysis of lnc-HLX-2-7 interacting genes and pathways in medulloblastoma
To gain more insights into the functional significance of lnc-HLX-2-7, gene expression profiles were...
GSE147529: Global gene expression of Oscar Knock-out (KO) mice with Wild Type (WT) mice.
Purpose: RNA sequencing (RNA-Seq) analyses of articular cartilage obtained after DMM surgery in Osca...
GSE149624: Post-transational regulation of the exon skipping machinery controls aberrant splicing in T cell leukemia [Jurkat_SI_24hr_300bp]
In this study, we show that pediatric T-cell acute lymphoblastic leukemia (T-ALL) has an alternative...
GSE152714: Seminal Plasma-Derived Extracellular-Vesicle Fractions from HIV-Infected Men Exhibit Unique MicroRNA Signatures and Induce a Proinflammatory Response in Cells Isolated from the Female Reproductive Tract
The continuing spread of HIV/AIDS is predominantly fueled by sexual exposure to HIV-contaminated sem...
GSE153633: The role of Arid4b in mESC lineage commitment (RNA-Seq)
Distinct cell types emerge from embryonic stem cells through a precise and coordinated execution of ...
GSE151501: Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and CTCF cKO Transcriptomes
Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular path...
GSE150665: Repression of p53-target gene Bbc3/puma by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance
MYSM1 is a transcriptional regulator essential for HSC function and hematopoiesis. We established th...
GSE147590: The histone variant macroH2A1 regulates key genes for myogenic cell fusion in a splice-isoform dependent manner [RNA-Seq]
MacroH2A histone variants have functions in differentiation, somatic cell reprogramming and cancer. ...
GSE149162: STIM1-mediated gene expression in non-pathogenic and pathogenic CD4+ Th17 cells
Immunity to fungal infections is mediated by cells of the innate and adaptive immune system. Activat...
GSE153392: transcriptomic comparison of CpG and MPL treatment in bone marrow derived dendritic cells (BMDC)
We report the comparison of TLR9 agonist CpG and TLR4 agonist MPL alone and in combination on the ge...
GSE153607: Distinct waves from the hemogenic endothelium give rise to layered Lymphoid Tissue Inducer cell ontogeny [bulk RNA-seq]
LTi cells are part of the ILC family and essential for the formation of secondary lymph nodes within...
GSE151728: Intrauterine inflammation-induced transcriptome changes in the mouse placenta
Placental insufficiency is implicated in the intrauterine infection-associated spontaneous preterm b...
GSE143988: Lgr5-negative cancer cells seed metastases in colorectal cancer
Cancer stem cells (CSCs) are a minority population of cancer cells that display stem cell-like multi...
GSE153432: Prp19 is an independent prognostic marker and promotes neuroblastoma metastasis by regulating the Hippo-YAP signaling pathway [SK-N-AS]
This study first reveals that Prp19 is a potential oncogene in neuroblastoma, which is significantly...
GSE140290: Expression analysis of colonic and small intestinal neurons in the germ-free (GF) and specifric pathogen-free (SFP) mice
Neural control of visceral organ function is essential for homeostasis and health. Intestinal perist...
GSE152588: YFV Capsid changes to mRNA transcriptome of Huh7 cells
Genome-wide analysis of changes to mRNA transcript levels upon expression of YFV capsid in Huh7 cell...
GSE153424: Simultaneous profiling of transcriptomes and lineage relationships in single cells and tissues
We report TREX for simultaneous lineage tracking and expression profiling of dissociated cells from ...
GSE150421: mRNA profiling after knockdown of lncRNA Cyrano
Pluripotency is tightly regulated via versatile pathways and is crucial for the maintenance of stem ...
GSE154874: Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy: Bulk Tumor RNA Sequencing for Rag2-/- and Rag2+/- primary p53/MCA tumors
Abstract: Immunotherapy fails to cure most cancer patients. Preclinical studies indicate that radiot...
GSE149724: Characterization of resistance to prexasertib in ovarian cancer cell line OVCAR5
We developed a CHK1 inhibitor Prexasertib resistant strain of ovarian cancer cell line OVCAR5 in lab...
GSE151799: Effect of dmPGE2 radioprotection on hematopoietic stem cell (HSC) gene expression 1 h and 24 h after lethal irradiation
DmPGE2 predominantly interferes with IR-induced p53-downstream apoptotic gene expression at 1 h, and...
GSE145766: Transcriptomic analysis reveals autophagy flux variation within mouse pancreatic cancer organoids
Murine pancreatic cancer cells (HY15549 cells) established from genetically engineered mouse models ...
GSE149638: ASEP: gene-based detection of allele-specific expression cross individuals in a population by RNA sequencing
Allele-specific expression (ASE) quantifies the relative expression of two alleles in a diploid indi...
GSE155766: RNA Sequencing facilitates quantitative analysis of differently expressed genes with GA or SKN treatment in rheumatoid fibroblast-like synoviocytes
To explore downstream gene expression profile of PKM2,we evaluated the transcriptome of GA- or SKN-t...
GSE150698: Ikk2-mediated inflammatory activation of arterial endothelial cells promotes the development and progression of atherosclerosis
Inflammatory activation of endothelial cells is considered to be the first step in the development o...
GSE151586: Oleic Acid Induces Tissue-Resident FOXP3 Regulatory T Cell Suppressive Functions (bulk RNA)
Comparing the transcriptomic program induced by oleic acid to that of the pro-inflammatory arachidon...
GSE143459: RUNX1-EVI1 disrupts lineage determination and the cell cycle by interfering with RUNX1 and EVI1 driven gene regulatory networks [RNA-seq]
Hematological malignancies are characterised by a block in differentiation, which is in many cases c...
GSE156894: Transcriptional profiling of hepatocyte, reprogrammed hepatocyte, and biliary cells
Following liver injury, a subset of hepatocytes adopt features of biliary epithelial cells (BECs) in...
GSE149705: HCMV-UV and SeV-UV infection of IFNAR KO and wildtype human fibroblasts
Type 1 interferon (IFN) plays a critical role in early antiviral defense and priming of adaptive imm...
GSE153398: Prp19 is an independent prognostic marker and promotes neuroblastoma metastasis by regulating the Hippo-YAP signaling pathway [SK-N-BE(2)]
This study first reveals that Prp19 is a potential oncogene in neuroblastoma, which is significantly...
GSE151597: RNA-seq of hepatic mRNA from 21 week old PAI-1 +/- and littermate control mice fed standard chow
We report RNA-seq data from hepatic mRNA on WT and PAI-1 heterozygous 21 week old mice. SOURCE: Doug...
GSE152699: Next Generation Sequencing of human BRAF melanoma cell lines treated with vemurafenib for 20 days
Purpose: The goals of this study are to compare NGS-derived transciptomes from human melanoma cell l...
GSE143972: Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function [gene expression/RNA-seq]
Regulatory T (Treg) cells require Foxp3 expression and induction of a specific DNA hypomethylation s...
GSE140371: FSH-regulated gene expression in mouse granulosa cells as revealed by ChIP- and RNA- Sequencing
Follicle stimulating hormone (FSH) regulates ovarian follicular development through a specific gene ...
GSE155081: Single cell RNA-seq analysis reveals compartment-specific heterogeneity and plasticity of microglia
Microglia are heterogeneous and ubiquitous CNS-resident macrophages that maintain homeostasis of neu...
GSE143486: Contradictory of gene expression signatures for clinical prognostic prediction caused by update of reference genome and annotation
Gene expression estimates detected by RNA-sequencing technology vary with the updates of reference g...
GSE152727: Androgens Regulate Ovarian Gene Expression through Modulation of H3K27me3 in Granulosa Cells [RNA-Seq]
This study reports androgen-induced gene expression in granulosa cells of the ovary and provides a m...
GSE150740: Modeling Cellular Crosstalk and Organotypic Vasculature Development with Human iPSC-Derived Endothelial Cells (iPS-EC) and Cardiomyocytes (iPS-CM) [RNA-seq]
The aim was to study the effect of shear stress on iPS-derived endothelial cells (iPS-EC). iPS-ECs w...
GSE140432 (mouse): CHUK/IKKalpha loss in lung epithelial cells enhances NSCLC growth associated with HIF up-regulation
During the natural progression of Non-small-cell lung cancer (NSCLC), tumor cells evolve progressive...
GSE155851: The Neocortical Progenitor Specification Program Is Established through Combined Modulation of SHH and FGF Signaling
Identification of gene expression changes in cortex-specific Sufu knockout mice SOURCE: Samuel Pleas...
GSE153262: Radiation induces dynamic changes to the T cell repertoire in renal cell carcinoma patients
Strong evidence supports the tumor immune landscape as a determinant of patient responses to immunot...
GSE140291: Expression analysis of enteric neurons from the mice housed in different animal facilities (the Francis Crick institute and the University of Bern)
Neural control of visceral organ function is essential for homeostasis and health. Intestinal perist...
GSE149714: RNA-Seq Quantitative Analysis of the regulation of exosomes on metastasis related gene transcriptome in NPC cells
In our study, We found that exosomal transfer occurred from highly metastatic nasopharyngeal carcino...
GSE152750: Mouse Embryonic Fibroblasts (MEFs) Adipogenic Potential: A Comprehensive Transcriptome Analysis
Exploration into the dynamic process of adipogenesis in MEF cells via transcriptome analysis SOURCE...
GSE151824: Spatiotemporal sequence of mesoderm and endoderm lineage segregation during mouse gastrulation
Anterior mesoderm (AM) and definitive endoderm (DE) progenitors represent the earliest embryonic cel...
GSE140292: Expression analysis of colonic neurons stimulated with AhR agonist (3-methylcholanthrene)
Neural control of visceral organ function is essential for homeostasis and health. Intestinal perist...
GSE144018: Prom1-deficiency effects on mouse primary hepatocyte transcriptomes in serum-free condition
Purpose: The function of Prom1, a penta-transmembrane glycoprotein which is a used as cancer stem c...
GSE149195: Sequencing to determine the effect of neuronal IL-1b receptor knockout on the stress effect of paired fighting social defeat in mice
Chronic stress contributes to the development of psychiatric disorders including anxiety and depress...
GSE143955: RNAseq profiling of skin samples from wild type and RIPK1E-KO mice
Keratinocyte-specific RIPK1 deficiency causes skin inflammation due to ZBP1-induced necroptosis. RNA...
GSE153443: The effect of decitabine (DAC) treatment on glioma cells
The objective of this study is to identify molecular determinants of DAC response in gliomas SOURCE:...
GSE143523: Parallel analysis of H3K9ac reveals Dux-dependent 2C activation deficiency in mouse SCNT embryos
Somatic cell nuclear transfer (SCNT) enables gaining of totipotency by reprogramming nuclei of termi...
GSE150874: Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer [mouse]
Tumor cells rely on glutamine to fulfill their metabolic demands and sustain proliferation. The elev...
GSE153301: P38 Regulates Expression of DUX4 in Facioscapulohumeral Muscular Dystrophy
Here, we describe the identification and characterization of p38 as a novel regulator of DUX4 expres...