PLX042727

GSE148301: Identification of Hepatic Genes Regulated by ATF3 using Next Generation Sequencing

Organsim mouse
Type RNASEQ
Target gene
Project ARCHS4

This study aimed to investigate how many genes were regulated by hepatocyte ATF3. C57BL/6J mice were injected intravenously with adeno-associated virus (AAV) expressing human activating transcription factor 3 (ATF3) under the control of an albumin promoter (AAV8-ALB-ATF3) or AAV8-ALB-Null). After 8 weeks, liver samples were used for RNA sequencing using Illumina NextSeq 500. Over 3000 genes were found to be up- or down-regulated by ATF3. SOURCE: Yanqiao Zhang (yzhang@neomed.edu) - Northeast Ohio Medical University

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