PLX204481

GSE152281: Single cell profiling shows that murine forebrain neural stem cells reacquire a developing precursor state when activated to make adult-born neurons

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

In this study, we have utilized a single-cell RNA-Sequencing platform coupled with transgenic lineage tracing in order to follow the progression of different embryonic neural stem cell populations as they progress into adult dormant neural stem cells. We show that adult dormant V-SVZ neural stem cells of different embryonic origins share a common molecular signature and reacquire an embryonic precursor-like state when activated to make new neurons in the adult brain. SOURCE: Freda Miller (fredam@sickkids.ca) - Hospital for Sick Children

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