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Sequencing-based assays (Page 72)
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GSE115787: The MybMuvB complex is required for YAP dependent transcription of mitotic genes
YAP/TAZ, downstream effectors of the Hippo pathway, are important regulators of proliferation. Here ...
GSE115937: Simultaneous quantification of antibody-RNA conjugates and the transcriptome from fixed cells by RAID
Undifferentiated and differentiated Keratinocytes (AG1478 treated) were stained with antibody-RNA co...
GSE108624: KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development
Balanced symmetric and asymmetric divisions of neural progenitor cells (NPCs) are crucial for orderl...
GSE109413: Spatial reconstruction of single enterocytes uncovers broad zonation along the intestinal villus axis
The intestinal epithelium is a highly structured tissue composed of repeating crypt-villus units. En...
GSE116193: Enhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks.
To fully comprehend how genetic variants influence phenotypes, we must understand the functions of t...
GSE115110: NF-Y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region
Faithful transcription initiation is critical for accurate gene expression, yet the mechanisms under...
GSE79284 (human): Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition (RNA-seq)
Our study shows that acute myeloid leukemia (AML) cells require the BRD9 subunit of the SWI/SNF chro...
GSE116288: Transcriptional profiling of murine ABC-DLBCL-like tumors [RNA-seq]
We have developed a novel immunocompetent multi-lesion mouse model of activated B cell diffuse large...
GSE116204: TET enzymes augment AID expression via 5hmC modifications at the Aicda superenhancer [RNA-seq]
TET enzymes are dioxygenases that promote DNA demethylation by oxidizing the methyl group of 5-methy...
GSE136013: Mirc11 selectively regulates inflammatory responses of NK cells by targeting ubiquitin modifiers and TRAF6-dependent NF-kB and AP1 activation (RNA-seq: Listeria_challenge)
Lack of Mirc11 significantly reduces NK cell-mediated cytokine production in vivo; Mirc11 cluster ta...
GSE117989: Helios expression defines two distinct populations of Foxp3+ Treg cells
The transcription factor Helios is expressed in a large subset of Foxp3+ Tregs of both mouse and man...
GSE132703: mTORC1 controls a dynamic program of TOP mRNA translation via LARP1
LARP1 has been proposed to control the translation of TOP mRNAs downstrteam of mTORC1. Here we used ...
GSE121373: T cell regeneration from pluripotent stem cells by defined transcription factors [T cells [CD4 and CD8])
We established a de novo approach of generating T cells from mouse ESC/iPSC by defined transcription...
GSE116286: Dynamic BAF chromatin remodeling complex subunit inclusion promotes temporally distinct gene expression programs in cardiogenesis [RNA-Seq II]
We performed differential mRNA analysis in WT and BRG1 KO cells during cardiac precursor and cardio...
GSE115609: Transcriptional profiling of MCF7 cells treated with H3B05942, E2, or standard of care compounds
The objective of this experiment was to compare the affect of H3B-5942 treatment on global gene exp...
GSE140107: Low-dose decitabine priming endows CAR T cells with enhanced and persistent anti-tumor potential by epigenetic reprogramming
Chimeric antigen receptor T (CAR T) cells targeting CD19 have achieved breakthroughs in the treatmen...
GSE122791 (mouse): The Type I interferon response impairs differentiation potential of pluripotent stem cells [seq]
Upon virus infection,pluripotent stem cells neither induce nor respond to canonical Type I interfero...
GSE120097: Dazl regulates germ cell survival through a network of polA-proximal mRNA interactions [GC1-spg cells (parental line) Ribosome Profiling and RNA-seq]
The RNA binding protein Dazl is essential for gametogenesis, but its direct in vivo functions, RNA t...
GSE116776: Store-operated Ca2+ entry mediates cancer-induced inflammation in T cell acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is a malignancy of T cell progenitors that in most patie...
GSE116177: Haemopedia: Mouse Haematopoietic Gene Expression
Database of gene expression in different haematopoietic cell types at haemosphere.org. SOURCE: Carol...
GSE116268: RNA-Sequencing Analysis of AVF-CKD Murine Model
We studied a murine AVF in mice with chronic kidney disease (CKD). SOURCE: Daniel,Rothschild,OBrien ...
GSE136014: Mirc11 selectively regulates inflammatory responses of NK cells by targeting ubiquitin modifiers and TRAF6-dependent NF-kB and AP1 activation (RNA-seq: IL-2_expanded_NKG2D_stimulation)
Lack of Mirc11 significantly reduces NK cell-mediated cytokine production in vivo; Mirc11 cluster ta...
GSE108569: Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia
Peripherally derived macrophages infiltrate the brain after bone marrow transplantation and during c...
GSE112550: Setd2 regulates quiescence and differentiation of adult hematopoietic stem cells by restricting RNA polymerase II elongation
SET domain containing 2 (Setd2), encoding a histone methyltransferase, is associated with many hemat...
GSE128089: EBF1-mutant bone marrow stroma confers long-term changes in hematopoietic stem cell potential [HSC]
Crosstalk between mesenchymal stromal cells (MSCs) and hematopoietic stem and cells (HSCs) is essent...
GSE138413: Transcriptome analysis on OVA-GA(10) immunized GA-CFP mice
The goal of the study is to perform unbiased transcriptome analysis on spinal cord samples of immuni...
GSE116237: Towards minimal residual disease-directed therapy in melanoma
Many patients with advanced cancers achieve dramatic responses to a panoply of therapeutics, yet ret...
GSE108360: Lamin B2 controls nuclear envelope permeability and regulates cardiomyocyte regeneration
Heart muscle cells, cardiomyocytes, are highly differentiated cells that usually do not proliferate ...
GSE128288: Programmable RNA-guided RNA effector proteins built from human parts
Epitranscriptomic regulation controls information flow through the central dogma and provides new op...
GSE116181: Transcriptome and 5mC/5hmC of Trophoblast Stem Cells [RNA-seq]
RNA-seq of WT, Tet2-het and Tet2-KO mTSCs in stem-state, RNA-seq of WT and Tet2-KO mTSCs in vitro di...
GSE89798: Defining lineage potential and fate behavior of precursors during pancreas development
Pancreas development involves a coordinated process in which an early phase of cell segregation and ...
GSE108097: Mapping Mouse Cell Atlas by Microwell-seq
We developed Microwell-seq, a high-throughput and low-cost scRNA-seq platform using simple, inexpens...
GSE120099: Unveiling the Role of the Most Impactful Cardiovascular Risk Locus Through Haplotype Editing at Cell
The 9p21.3 cardiovascular disease locus is the most influential common genetic risk factor for coron...
GSE118017: Expression data from mouse bone marrow sinusoidal endothelial cells (SECs) before and after the ablation of classical dendrtic cells (cDCs)
The function of bone marrow sinusoidal endothelial cells may change upon the ablation of classical d...
GSE116010: Distinct stress response and altered striatal transcriptome in alpha-synuclein overexpressing mice
Using a mouse model overexpressing human SNCA and profiling the striatal transcriptome, we assessed ...
GSE124419: Characterization of mouse tissues by bulk RNA sequencing
Total RNA of mice tissues (liver, small intestine, lung and kidney) was extracted using liquid N2 an...
GSE117987: Podocyte-specific induction of Krppel-like factor 15 restores differentiation markers and attenuates kidney injury in proteinuric kidney disease
Podocyte injury is the hallmark of proteinuric kidney diseases, such as Focal Segmental Glomeruloscl...
GSE115172: Increased lactate secretion by cancer cells sustains non-cell-autonomous adaptive resistance to MET and EGFR targeted therapies.
Microenvironment is known to influence cancer drug response and sustain resistance to therapies targ...
GSE123681: Thymine DNA Glycosylase as a novel target for melanoma: effect of TDG silencing on gene expression in SK-mel-28 melanoma cells
Melanoma is an aggressive neoplasm with increasing incidence that is classified by the NCI as a reca...
GSE120086: Macrophage Ad5f35 M2 Challenge
Control untransduced or anti-HER2 CAR (Ad5f35 transduced) human macrophages were exposed to control ...
GSE116241: Identification of atheroprone shear stress responsive regulatory elements in endothelial cells
While variations in gene transcription networks in models of atherosclerosis have been reported, the...
GSE109660: RNA-sequencing (RNA-seq) of non-manipulated ventricular tissue only of 1- (P1) and 2-day (P2) old neonatal mice
Purpose: The goal of this study is to compare the NGS-derived from ventricular trascriptome profilin...
GSE119066: Perturbed maintenance of transcriptional repression on the inactive X-chromosome in the mouse brain after XIST deletion
The long noncoding RNA, Xist, is critical for initiation and establishment of X- chromosome inactiva...
GSE115955: Self-organization and symmetry breaking in intestinal organoid development [bulk RNA-Seq]
Intestinal organoids are complex three-dimensional structures that mimic cell type composition and t...
GSE118057: RNA-sequencing of mouse double-negative developing thymocytes [WT and Duxbl[ind]xpTa[Cre]]
We performed a transcriptome comparison of double-negative developing thymocytes from the DN3-4 popu...
GSE117706: Sertoli cell-only phenotype and single-cell RNA-seq define PRAMEF12 as a germline-specific factor for male stem cell maintenance and differentiation [RNA-Seq]
Spermatogonial stem cells (SSCs) have the dual capacity to self-renew and differentiate into progeni...
GSE120109: Antiviral and anti-inflammatory properties of novel anti-HIV candidate ABX464 promotes specifics RNA splicing while preserving cellular RNA integrity.
Purpose: To ensure that ABX464 acted specifically on HIV splicing and did not significantly or globa...
GSE115818: CARM1 (PRMT4) acts as a transcriptional coactivator during retinoic acid-induced embryonic stem cell differentiation
Our data demonstrate that CARM1 is required for transcriptional activation of a subset of retinoic a...
GSE135881: Glucagon-receptor signaling regulates energy metabolism via hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21
Glucagon, an essential regulator of glucose and lipid metabolism, also promotes weight loss, in part...
GSE120145: Robust, long-term culture of endoderm derived hepatic organoids (eHEPOs) for disease modeling
Many liver pathologies ranging from cancer to genetic metabolic diseases are amenable to cellular re...
GSE115608: Transcriptional profiling of Ishikawa cells treated with H3B-5942, E2, or standard of care compounds
The objective of this experiment was to determine the affect of H3B-5942 treatment on global gene e...
GSE116314: Transcriptomic changes in wild-type and Phlpp1-/- mice following KLA stimulation
The goals of this study are to compare transcriptome profiling (RNA-seq) of bone marrow derived macr...
GSE124443: Cell-based therapy restores olfactory function in an inducible model of anosmia
We explore culture coniditions that promote the expansion of engraftment-compentent olfactory basal ...
GSE119853: Global transcriptional profiling unveils the interferon network in blood and tissues across different diseases [RNA-seq_Lung_6_module_generation]
We have performed modular analyses to decipher the global transcriptional response and capture a bre...
GSE118046: Next Generation Sequencing Facilitates Quantitative Analysis of Normoxia/Hypoxia Human Dental Pulp Cells Transcriptomes
We report the application of high-throughput profiling of gene expression in human dental pulp cells...
GSE131566: Hyperactivation of Sympathetic Nerves Drives Melanocyte Stem Cell Depletion
Empirical and anecdotal evidence have associated stress with accelerated hair greying (formation of ...
GSE120190: Transcriptome analyses of iPSC-derived neural stem/progenitor cells and cerebral organoids from monozygotic twins discordant for schizoaffective bipolar disorder
To investigate the disease-associated differences in gene expression pattern during neuro developmen...
GSE111630: Changes in mRMA/protein expression and signaling pathways in in vivo passaged mouse ovarian cancer cells
The cure rate for late stage epithelial ovarian cancer (EOC) has not significantly improved over sev...
GSE117429 (mouse): Loss of CHD1 facilitates oncogenic hijacking of AR during cancer progression [RNA-seq]
Deregulation of chromatin architecture is emerging as a critical feature of carcinogenesis, and geno...
GSE115861: Comparison of single-cell transcriptomics quality between unfixed cells and cells that were fixed and mock stained according to the RAID procedure
Cell fixation, permeabilization and antibody staining of could have adverse effects on the quality o...
GSE126872: RNAseq - scERWT vs. scERKO
RNAseq performed on isolated satellite cells from scERWT and scERKO mice SOURCE: Dawn Lowe (lowex017...
GSE130969: Differential Gene expressionof furin knockout (KO) DLD1, HCA7 and HT29 colorectal cancer cells
We created furin KO cells in three colorectal cancer cell lines (DLD1, HCA7 and HT29) using CRISPR-C...
GSE109653: HOXA9 cooperates with activated JAK/STAT signaling to drive leukemia development
Leukemia is caused by the accumulation of multiple genomic lesions in hematopoietic precursor cells....
GSE140047: Overexpression of FOXL2 altered uterine structures and functions
Pgrcre/+Foxl2LsL/+ mice showed absence of corpus luteum in the ovary, thus the mice were infertile a...
GSE116832: Group I Paks are essential for epithelial-mesenchymal transition in an Apc-driven mouse model of colorectal cancer
p21-activated kinases (Paks) play an important role in oncogenic signaling pathways, and have there...
GSE116852: RNA-seq of KMT2D Knockout and KMT2D WT melanoma in mice
Somatic mutations in various epigenetic regulators, including histone methyltransferases KMT2C and K...
GSE116278: Dynamics of the transcriptional landscape during human gonad development during fetal life
Fetal life is a crucial period for sexual reproduction when bipotential gonads differentiate into ei...
GSE113214: The IRE1-XBP1 pathway promotes natural killer cell responses against viral infection and cancer by regulation of c-Myc
Natural killer (NK) cells are critical mediators of host immunity against infectious disease and can...
GSE116759: The effect of very-high-molecular-mass hyaluronan (vHMM-HA) on IMR90 transcriptome
Naked mole-rat skin fibroblasts (NSF) produces vHMM-HA. Although NSF-HA has been shown to suppress N...
GSE123925: A C/EBPWnt connection in gut homeostasis and carcinogenesis
We explored the connection between C/EBP (CCAAT/enhancer binding protein ) and Wnt signaling in gut ...
GSE119855: Global transcriptional profiling unveils the interferon network in blood and tissues across different diseases [RNA-seq_Toxoplasma_WT_IFNR_KO_4tissues]
We have performed modular analyses to decipher the global transcriptional response and capture a bre...
GSE116864: Transcriptomic Reprogramming of Prostate Cancer Cells Driven by Stroma-Derived AREG
Recent advances in next generation sequencing (NGS) has revolutionized systems-based analysis of cel...
GSE124284: B lymphocyte alterations accompany abatacept resistance in new-onset type 1 diabetes
Peripheral blood samples were collected from subjects enrolled in the TrialNet study TN-09. This was...
GSE135997 (mouse): Cyclophosphamide (CTX) Enhances Cancer Antibody Immunotherapy in the Resistant Bone Marrow Niche by Modulating Macrophage FcR Expression
Purpose: To understand the molecular mechanisms underlying the CTX synergization with antibody thera...
GSE120986: COMPASS Family Histone Methyltransferase ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling [RNA-seq]
We show that the COMPASS family histone methyltransferase co-factor ASH2L is required in NPCs prolif...
GSE121645: Translation Regulation of the Prolactin Receptor Defines Sexually Dimorphic Pain Responses to Prolactin
Transcriptional control by gonadal hormone nuclear receptors is the foundation for sex-dependent phy...
GSE109050: Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
The nuclear factor-kB (NF-kB) family of transcription factors is important for hematopoietic functio...
GSE108672: Polycomb Group Protein YY1 is an Essential Regulator of Hematopoietic Stem Cell Quiescence
Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular path...
GSE108400: Foxd1 is required for terminal differentiation of anterior hypothalamic neuronal subtypes
Although the hypothalamus functions as a master homeostat for many behaviors, little is known about ...
GSE121422: Inhibition of TAZ contributes radiation-induced senescence and growth arrest in glioma cells
Glioblastoma (GBM) is the most aggressive brain tumor and resistant to current available therapeutic...
GSE120081: Profiling of gene expression using RNA-Seq in fibroblasts, iPSCs, iPSC-derived neurons and cells overexpressing Onecut transcription factors
Remodeling of chromatin accessibility is necessary for successful reprogramming of fibroblasts to ne...
GSE135997 (human): Cyclophosphamide (CTX) Enhances Cancer Antibody Immunotherapy in the Resistant Bone Marrow Niche by Modulating Macrophage FcR Expression
Purpose: To understand the molecular mechanisms underlying the CTX synergization with antibody thera...
GSE79309: Functional Haploid Human Oocytes Generated from Polar Body Genomes (RNA-Seq)
Oocyte defects lie at the heart of some forms of infertility and could potentially be addressed ther...
GSE119873: Transcriptome differences between primary brown adipocytes of wildtype and UCP1-KO mice
We analyzed coding transcript abundance in fully differentiated, primary brown adipocytes from murin...
GSE122637: Transcriptome of draining lymph nodes from the mice immunized with RABV
Here we show the transcriptome of lymph nodes draining from RABV vaccinated B6 mice and TLR7 KO mice...
GSE132869: A murine systemic bleomycin model of scleroderma
A well-characterized mouse model of SSc involves daily subcutaneous injections of the antitumor anti...
GSE81928: Hepatic transcriptome of pediatric hepatoblastoma.
The mechanisms underlying hepatoblastoma are not well defined. To address this, we generated transc...
GSE111148: Kir4.1-dependent astrocyte-fast motor neuron interactions are required for peak strength
Diversified neurons are essential for sensorimotor function, but whether astrocytes become specializ...
GSE121419: Quizalofop-p-ethyl induces adipogenesis in 3T3-L1 cells
We provide here the alterations in gene expression profiles of 3T3-L1 cells, a validated model for a...
GSE120474: Transcription factors activate genes through the phase separation capacity of their activation domains [RNA-seq]
Gene expression is controlled by transcription factors (TFs) that consist of DNA-binding domains (DB...
GSE120997: Brain RNA-seq: Esomeprazole/stress interactions.
Purpose: The goals of this study were to evaluate the effects of acid suppression on the brain trans...
GSE122836: Nrf2 activation promotes lung cancer metastasis by blocking degradation of Bach1
Purpose: The goal of this study is to analyze the transcriptional pathways regulated by Fbxo22 and K...
GSE87534: Atheroprotective flow alters EZH2/H3K27me3 dependent transcriptional profile in human endothelial cells
Atherosclerosis is a focal disease that preferentially develop in the regions of atheroprone disturb...
GSE129665: RNA-sequencing of adipocyte and stromal vascular cells (SVCs) of epididymal and inguinal adipose tissue from high-fat diet (HFD)-fed mice
We report the transcriptomes of adipocytes and SVCs derived from HFD-fed obese mouse epididymal adip...
GSE111650: The effects of Lef-1 overexpression on culture-expanded MECs
The mouse trachea is thought to contain two distinct stem cell compartments that contribute to airwa...
GSE116810: XPO1 inhibition antagonizes MCL via nuclear retention of IkB: Selinexor demonstrates antitumor activities in both ibr-sensitive and ibr-resistant tumor cells
Inhibition of BCR signaling through BTK inhibitor, ibrutinib, has generated a remarkable response in...
GSE121591: RNA sequencing of primary acute lymphoblastic leukemia xenograft brains with and without treatment with chimeric antigen receptor T (CAR-T) cell therapy
NSG mice were IP injected with 30mg/kg busulfan. The following day, mice received 1,000,000-3,000,00...
GSE122486: RNA-sequencing WT vs SOCS3 knockout Glioblastoma stem-cells
Glioblastoma stem cells were infected with lentivirus expressing a non-targeting (gRNA-LacZ) or SOCS...
GSE110629: Next-generation sequencing of three memory OT-I cell subsets from mice infected with Listeria monocytogenes
Purpose: RNA-seq analysis of three memory OT-I cell subsets (from a Klrg1-Cre fate reporter mouse mo...
GSE93226: Transcriptomic profiles of human foreskin fibroblast cells in response to orf virus
Using RNA sequencing technology, we compared specic changes in the transcriptomic proles in human fo...