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Sequencing-based assays (Page 53)
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GSE115130: RNAseq of laser captured spinal and oculomotor neurons in post mortem material of ALS patients
Gene expression profiles of specific neuronal populations might explain differential vulnerability t...
GSE97388: In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells
Understanding the unique mechanisms of human oogenesis necessitates the development of an in vitro s...
GSE98731: Metformin reduces air pollution-induced thrombosis
As our results suggested that metformin acts to limit mitochondrial ROS and calcium-mediated activat...
GSE106546: Deciphering the role of importin alpha in mammalian central neurons - Hippocampal gene expression profiling in importin alpha5-deleted mice
Introduction: The mechanisms governing synaptonuclear transport, and the transcriptional pathways th...
GSE86389: Kap1 in liver physiology
Hepatocellular carcinoma (HCC) represents the fifth most common form of cancer worldwide and carries...
GSE109877: Bi-directional interaction between mesenchymal stem cells and transit amplifying cells in mesenchymal tissue homeostasis [Axin2beta]
We sequenced mouse incisor mRNA from 6 mice (3 WT and 3 mutant) to compare their gene expression pro...
GSE111353: FOXP2 regulates differential transcriptional programs in human subplate
Mammalian brains are highly conserved at both the neuroanatomical and gene expression levels. Howeve...
GSE97389: Stabilization of NIK suppresses MLL-AF9-induced acute myeloid leukemia
Comparison of transcriptome between control and NIK-stabilized leukemia stem cells SOURCE: Thomas,B,...
GSE97509: CD27 marks embryonic hematopoietic stem cells
Cell surface markers of adult hematopoietic stem cells (HSCs) are well established, but fewer marker...
GSE89817: RNA sequencing reveals resistance of TLR4 ligand-activated microglial cells to inflammation mediated by the selective jumonji H3K27 demethylase inhibitor
Persistent microglia activation is associated with the production and secretion of various pro-infla...
GSE102924: Glioblastoma stem cells infected by ZIKA virus
We repoted the Glioblastoma stem cells(GSCs) infected by two strains of ZIKA virus, the Brazil and D...
GSE102867: RNA-Seq Profiling of Intestinal Expression of Xenobiotic Processing Genes in Germ-Free Mice
This study aimed to quantify and compare the mRNA abundance of all major XPGs in liver and intestine...
GSE96871: Gene expression changes in the supraorbital cranial mesenchyme after beta-catenin deletion in vivo
Goal of this study was to examine gene expression changes upon conditional deletion of beta-catenin ...
GSE96646: Next Generation Sequencing Analysis of gene expression profile in Dgcr8 conditional KO embryonic hearts
Purpose: To compare the transcriptome of wild type and Mesp1Cre+/Dgcr8-/- embryonic heart at embryo...
GSE97118: RNA-sequencing analysis of differentiating wildtype and Ezh2 deficient immature mouse chondrocytes
Objective: To evalute the role of Ezh2 in chondrocyte differentiation.; Method: Ezh2 was inactivated...
GSE97996: Differential gene expression pattern of mouse livers transfected with dual oncogenes
To understand global gene expression patterns of mouse livers upon dual-oncogene transfection, RNA s...
GSE120063: A CHAF1B-dependent molecular switch in hematopoiesis and leukemia pathogenesis
CHAF1B is the p60 subunit of the chromatin assembly factor (CAF1) complex, which is responsible for ...
GSE98469: Transcriptional effects of dominant-negative G784E Smarca4 mutation in mouse embryonic stem cells [RNA-seq]
We investigated transcriptomic effects of a Smarca4 ATPase mutant observed in primary tumors and can...
GSE99684: Pronounced Strain-Specific Chemosensory Receptor Gene Expression in the Mouse Vomeronasal Organ
Our study reports strain specific expression and abensce of sexual dimorphic expression in mouse vom...
GSE99251: Olfactory stem cell-mediated regeneration: horizontal basal cell (HBC) lineage [scRNA-seq]
The lineage of the horizontal basal cells (HBC) stem cells and their descendants from the olfactory ...
GSE109683: Differential gene expressions of human pluripotent stem cells derived cells in different culture system
Human pluripotent stem cells (H9s) were differentiated into endothelial cells (ECs), neural stem cel...
GSE97721: Lineage Reprogramming of Fibroblasts into Functional Neurons and Hepatocytes via Chemically Induced XEN-like State
Small-molecule based lineage reprogramming has newly emerged as a promising approach for generating ...
GSE97654: MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma
We present three mouse models of kidney cancer that recapitulate the genomic alterations found in hu...
GSE98091: Transcriptomic analysis of the HOTAIR-regulated genes
An integrated RNA sequencing transcriptomic and quantitative proteomic analysis were employed to sys...
GSE92614: PTEN is essential in the maintenance of normal transporter activity in the epididymal epithelium
A fully developed initial segment, the most proximal region of the epididymis, is important for male...
GSE126030: A single cell reference map for human blood and tissue T cell activation
Human T cells coordinate adaptive immunity by localization in diverse tissue sites, though blood T c...
GSE98468: RNA-Seq analysis of alveolar macrophages from normal and fibrotic mouse lungs
We performed gene expression profiling of alveolar macrophages from mice that were intratracheally i...
GSE103723: Single cell RNA-seq analysis of human embryonic cortex
Many studies have been launched to investigate cellular and molecular regulation regarding human neu...
GSE99302: Asymmetry of gene expression in embryonic and foetal human brains
Note: this project is a combination of the data deposited here in GEO and data made available by HD...
GSE93127: Comprehensive characterization of neutrophil genome topology
Neutrophils are responsible for the first line of defense against invading pathogens. Their nuclei a...
GSE98836: EWSR1 influences alternative splicing through direct and indirect mechanisms
FET family RNA binding proteins are implicated in cancer and neurological disorders and yet their bi...
GSE115012: RNA sequencing analysis of metabolism related genes in MKRN1-null mice tissues.
Analysis of metabolism related gene expression in liver and adipose tissues from MKRN1 knockout mice...
GSE125504: RNA-Seq analysis of human Tr1, Tregs and IL10neg cells
To determine the differentially expressed genes between these subsets and identify the core human in...
GSE104995: Single cell transcriptomes of cord blood derived subsets of human haematopoietic stem cells, LMPP and MLP myelo-lymphoid restricted progenitors [49f+ HSCs, 49f+ Subset1, 49f+ Subset2, Subset1, Subset2]
Integration of index sorting and single cell functional assays allowed identification of novel haema...
GSE146438: Engineered IL-10 variants elicit potent immuno-modulatory activities at therapeutic low ligand doses
Interleukin-10 is a dimeric cytokine with potent anti-inflammatory and anti-cancer activities. Despi...
GSE99651: Culture-induced recurrent epigenetic aberrations in human pluripotent stem cells [RNA-seq]
Human pluripotent stem cells (hPSCs) are an important player in disease modeling and regenerative me...
GSE99701: Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-Seq
Purpose: Transport processes in the renal collecting duct are responsible for precise regulation of ...
GSE90070: A unique ISR Program Determines Cellular Responses to Chronic Stress
Integrated Stress Response (ISR) is a homeostatic mechanism induced by endoplasmic reticulum (ER) st...
GSE109883: Global gene expression profiling reveal distinct molecular profiles between p53-sensitive and p53-resistant T-cell lymphomas
TP53 mutations occur in approximately 50% of all human tumors with increased frequency in aggressive...
GSE98690: Thyroid hormone receptor beta in the ventromedial hypothalamus is essential for the physiological regulation of food intake and body weight
The obesity epidemic is a significant global health issue. Improved understanding of the mechanisms ...
GSE99658: Viable RNaseH1 knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver function
Using RNAseq we describe transcriptional changes downstream of liver-specific knockout of RNaseH1, i...
GSE108811: Endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases
Latent pancreatic cancer metastases are created when T cells select disseminated cancer cells in whi...
GSE134878: Gene Expression Analysis of Essential Tremor via RNA-sequencing
RNA-seq evaluation of post-mortem human cerebelllum from 33 patients with diagnosed Essential tremor...
GSE99687: Smad5 acts as an intracellular pH messenger and maintains bioenergetic homoeostasis
we report here that Smad5 acts as a pHi messenger and maintains bioenergetic homeostasis of a cell b...
GSE98839: Emerging pathways of dystonia pathogenesis: eIF2 and neuroplasticity defects in DYT6
Dystonia is characterized by involuntary muscle contractions. Its many forms are genetically, phenot...
GSE102560: Cooperative and Antagonistic Transcriptional Regulation by BRG/BRM [RNA-seq]
We monitored the transcription changes associated with loss of BRG1, BRM, or both combined I HepG2 c...
GSE97440 (human): RNA-sequencing of human leukemia cells and mouse hematopoietic progenitors
human leukemia cells treated with vitamin C for 12 and 72hrs and mouse hematopoietic progenitor cell...
GSE99009: SUMO safeguards somatic and pluripotent cell identities by enforcing distinct chromatin states
Purposes: (1) compare the SUMO chromatin landscape between mouse embryonic fibroblasts (MEFs) and em...
GSE98497: Comparing the Transcriptomes of Wild Type and Mtor-Gdf9-Cre mediated Oocyte-Conditional Knockout Mouse ovaries by RNA-Seq Analysis
The goal of this study is to identify the differentially expressed genes in Gdf9-Cre mediated Mtor o...
GSE89210: PRC2 facilitates the regulatory topology required for poised enhancer function during pluripotent stem cell differentiation [RNA-seq EED]
Poised enhancers marked by H3K27me3 in pluripotent cells were previously proposed to facilitate the ...
GSE98492: Transcriptional profile of TL1A transgenic mice
To assess the effect of different forms of TL1A within different organs of the mouse we generated 2 ...
GSE107994: A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection [Leicester progressor]
Whole blood transcriptional signatures distinguishing patients with active tuberculosis from asympto...
GSE99076: Gene knockout of Zmym3 in mice arrests spermatogenesis at meiotic metaphase with defects in spindle assembly checkpoint
To elucidate the molecular bases for the infertile phenotype of Zmym3 KO mice at the mRNA expression...
GSE100222: Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation
Molecular definition of an RNA-mediated mechanism that stabilizes association of the Suv39h enzymes ...
GSE100427: CUREfast: Accelerating research with families
RNA sequencing of tissue samples taken from pediatric cancer patients of varying disease type. Patie...
GSE98119: The energetics and physiological impact of cohesin extrusion
Cohesin extrusion is thought to play a central role in establishing the architecture of mammalian ge...
GSE136355: Gene expression profiling of E1A;HrasG12V mouse embryonic fibroblasts grown under physiological (5%) oxygen conditions, with wild-type p53 or p53 null
To investigate how pleiotropic the impact of p53 loss is on cellular function, generated isogenic, p...
GSE99040: Reprogramming of Schwann Cells by LATS1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis
Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive Schwann cell (SC)-lineage de...
GSE93824: Role of Microglial C5aR1 in the Arctic Alzheimers Disease Mouse Model
C5aR1, a receptor for the complement activation proinflammatory fragment, C5a, is primarily expresse...
GSE96526: Expression data that were specifically regulated by lncRNA-LFAR1 in mouse primary HSCs
Long noncoding RNAs (lncRNAs) play important roles in various biological processes; however, few hav...
GSE99068 (human): IL-6/Stat3-Dependent Induction of Distinct, Obesity-Associated Natural Killer Cells Deteriorates Energy and Glucose Homeostasis
Natural killer (NK) cells contribute to the development of obesity-associated insulin resistance. We...
GSE98884: Anti-inflammatory effect of indoleacrylic acid (IA)
Host factors in the intestine, such as mucus secretion, play an important role in selecting for the ...
GSE99046: Sema6D reverse signaling controls lipid metabolism for macrophage polarization linking mTOR to PPAR
The goal of this study is to compare downstream genes of Sema6D signaling in both M1 and M2 macropha...
GSE99970: Thiol-linked alkylation for the metabolic sequencing of RNA [SLAM-seq pulse/chase labeling in wildtype mES cells]
Gene expression profiling by high-throughput sequencing reveals qualitative and quantitative changes...
GSE99310 (human): Enhancer reprogramming promotes pancreatic cancer progression and metastasis [RNA-seq]
Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human malignancies, owing in part t...
GSE99081: External RNA Control Consortium (ERCC) spikes in RNA sequencing (RNA-Seq) data normalization: transcriptome analysis of yellow fever virus-infected cells
We explored the ability of External RNA Control Consortium (ERCC) standards to detect technical bias...
GSE103871: TMPRSS2-ERG suppresses PTEN/TP53 alteration-induced cancer lineage plasticity
Lineage plasticity is a major mechanism driving prostate cancer progression and antiandrogen therapy...
GSE98519: Identification of Lef1-dependent genes in zebrafish and mouse hypothalamus
We performed RNA-seq with dissected control and Lef1 mutant hypothalami from 3 days post-fertilizati...
GSE99724: Gene expression activation in CLL mediated by MSCs contact
Survival of primary CLL cells is mediated by mesenchimal stromal cells in vitro. The goal of this st...
GSE93061: Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development [RNA-seq 2]
Purpose: To asses changes in gene expression profiles from the P30 wild type littermate control olfa...
GSE89242: Poised enhancers regulatory activity is topologically facilitated by polycomb [RNA-seq LHX5]
Poised enhancers marked by H3K27me3 in pluripotent cells were previously proposed to facilitate the ...
GSE98812: Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance (RNA-Seq)
BACKGROUND: Targeted therapies specifically act by blocking the activity of proteins that are encode...
GSE98590: Tolerogenic transcriptome landscape in CD8+ T lymphocytes after exposure to erythrocyte-targeted antigen
Our group has recently shown induction of antigen-specific T cell tolerance through targeting antige...
GSE99745: RNA-Seq of polysome profiling fractions and whole cell lysates of UVB-irradiated N-TERT keratinocytes
In response to UVB irradiation, human keratinocytes transiently block cell cycle progression to allo...
GSE102240: RNA-sequencing of WT and Asic3-null leukemia-initiating cells (LICs)
To tease apart the downstream signaling triggered by the Asic3-mediated ion current, RNA-sequencing ...
GSE105088: Identification of an IL-1-induced gene expression pattern in AR+ PCa cells that mimics the molecular phenotype of AR- PCa cells
In immunosurveillance, bone-derived immune cells infiltrate the tumor and secrete inflammatory cytok...
GSE93537: Gene expression changes upon deletion of CFP1 in mouse ES cells. [mESC_RNAseq]
Chromatin modifications and the promoter associated epigenome are thought to be important for the re...
GSE89621: Characterization of transcriptome changes induced in 3T3L1 adipocytes by expression of Adenovirus subtype 5 protein E4-ORF1
Insulin activation of phosphoinositol 3-kinase (PI3 kinase) regulates metabolism, including the tran...
GSE108480: Differential 3 Processing of Specific Transcripts Expands Regulatory and Protein Diversity Across Neuronal Cell Types
Alternative polyadenylation (APA) regulates mRNA translation, stability, and protein localization. H...
GSE108794: Nuclear miRNA-mediated gene silencing dependent on Argonaute proteins is required for embryonic stem cell differentiation [1_Differentiation_rna_seq]
Here, we show that embryonic stem cells (ESCs) and muscle stem cells contain high levels of nuclear ...
GSE106601: tRNA modification landscape selectively controls mitochondrial translation efficiency in MERRF
We identified a novel N1-methyladenosine (m1A) modification in tRNALys with distinct effects on the ...
GSE135578: RNA Sequencing analysis of xenografts for mouse gene expression changes
Control and 2G8-treated MiaPaca-2 and Colo375 xenografts were subjected to RNA-seq analysis for mous...
GSE103219: Haploinsufficiency for SIX2 increases nephron progenitor proliferation leading to elevated branching and nephron number
The regulation of final nephron number in the kidney is poorly understood. However, cessation of nep...
GSE93570: Chromatin State and Binding of Lhx2 and Ebf in Olfactory Sensory Neurons
The monoallelic expression of olfactory receptor (OR) genes is governed by the formation of large do...
GSE89758: RNA-seq of Tumor-associated Endothelial Cells from Different Immunodeficient Backgrounds
To investigate the impact of CD4+ T cells on tumor vasculature, we performed transcriptome profiling...
GSE89960: An environment-dependent transcriptional network regulates human microglia phenotypes
Microglia play essential roles in central nervous system (CNS) homeostasis and influence diverse asp...
GSE151669: CD28 Co-stimulation Drives Tumor-Infiltrating T Cell Glycolysis to Promote Inflammation
Metabolic reprogramming dictates the fate and function of stimulated T cells, yet these pathways can...
GSE90962: Integrative analysis of sex-specific microRNA networks following stress in mouse nucleus accumbens
Adult women are twice as likely as men to suffer from affective and anxiety disorders, although the ...
GSE101996: RNAseq of CD45+ cells excluding mast cells from the skin of K14HPV16 Mcpt5-Cre- and K14HPV16 Mcpt5-Cre+ mice
The experiment aimed at determing the influence of mast cell deficiency on the transcriptome of skin...
GSE100473: Effect of O-GlcNAc transferase deficiency on intestinal epithelial cells in mice
O-GlcNAcylation is the modification of serine and threonine residues with beta-N-acetylglucosamine (...
GSE98810: Gene expression profile in endotoxin stimulated murine primary macrophages
We report high-throughput profiling of gene expression from murine primary macrophages. We profile m...
GSE103930: RNA sequencing analysis of triple cytokine-captured human CD4 T cells
GM-CSF positve CD4 cells are found at sites of inflammation. The purpose of this study was to unders...
GSE99596: SIRT7 Antagonizes TGF- Signaling and Inhibits Breast Cancer Metastasis
Protein deacetylase SIRT7 is significantly downregulated in lung metastases of human patient and mou...
GSE100751: Repression of stress-induced LINE-1 expression protects cancer cell populations from lethal drug-exposures [RNA-Seq]
DTP heterochromatin in genomic repeat regions protects the population from drug-induced death. SOURC...
GSE89219: Global transcriptional profiling of HEK293 cells transfected with ATFs, mouse embryonic fibroblasts, and mouse iPS cells derived with artificial transcription factors
We tested various architectures of artificial transcription factors (ATFs) in HEK293 cells to test t...
GSE98368: IFN- Represses M2 Gene Expression in Human Macrophages by Suppressing and Disassembling MAF-binding Enhancers [RNA-seq]
Mechanisms by which IFN- activates genes to promote macrophage activation are well studied, but litt...
GSE95093: Transcriptional convergence of oligodendrocyte lineage progenitors during development
Pdgfra+ oligodendrocyte precursor cells (OPCs) arise in distinct specification waves during embryo- ...
GSE99977: Thiol-linked alkylation for the metabolic sequencing of RNA [SLAM-seq of wildtype mES cell RNA +/- iodoacetamide treatment]
Gene expression profiling by high-throughput sequencing reveals qualitative and quantitative changes...
GSE98843: Epigenome analysis reveals novel aspects of ILC2 activation and supports a pathogenic role in asthma
Recent studies have shown that group 2 innate lymphoid cells (ILC2s) can drive eosinophilic airway i...
GSE102316: Translational Regulation in Initial Stages of the Neuronal Injury Response
Transcriptional events leading to outgrowth of neuronal axons have been intensively studied, but the...