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Sequencing-based assays (Page 20)
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GSE100070: Formin 2 Links Neuropsychiatric Phenotypes At Young Age To An Increased Risk For Dementia
Age-associated memory decline is due to variable combinations of genetic and environmental risk fact...
GSE86065: Time course effects of a latent carcinogen in mice
Early-life environmental factors can increase later-life susceptibility to cancer. Short-term exposu...
GSE90976: TET2 loss and the lymphoma-associated RHOA mutation cooperate to disrupt CD4+ T cell function through inactivation of FOXO1
Angioimmunoblastic T cell lymphoma (AITL) represents a distinctive form of peripheral T cell lymphom...
GSE96561: Gene expression profile during cardiac stress induced by transverse aortic constriction (TAC) and myocardial infarction (MI) with or without BET protein inhibitor JQ1 in mouse hearts
Purpose: to reveal cardiac stress-inducible genes that are attnuated by BET inhibition SOURCE: Sapta...
GSE110325: Mycobacterium tuberculosis tRNA induces IL-12p70 via synergistic activation of pattern recognition receptors within a cell network.
Analysis of gene expression profiles identified a mycobacterial tRNA-induced innate immune network r...
GSE135981: A NeuroD1 AAV-Based Gene Therapy For Functional Brain Repair After Ischemic Injury Through In Vivo Astrocyte-To-Neuron Conversion
NeuroD1-mediated in situ astrocyte-to-neuron conversion can regenerate a large number of functional ...
GSE94549: Effect of MDK expressing Melanoma cells conditioned media in Human LEC
Gene expression analysis in hLECs treated with gain of function or loss of function of MDK in human ...
GSE90913: Altered Nucleocytoplasmic Proteome and Transcriptome Distributions in an In Vitro Model of Amyotrophic Lateral Sclerosis
An integrated analysis of the nucleocytoplasmic distribution of the proteome and transcriptome demon...
GSE85414: Protection against maternal infection-associated fetal growth restriction: proof-of-concept with a microbial-derived immunomodulator
Infection-associated inflammatory stress during pregnancy is the most common cause of fetal growth r...
GSE102231: High TCR self-reactivity drives regulatory T cell function during tissue-specific autoimmunity
Tregs with high self-reactivity are a potent suppressive population in preventing tissue-specific au...
GSE109908: RNA seq from liver samples of C57BL/6 mice to study the gene expression synchrony of Plasmodium stages with host circadian cycle.
The Plasmodium life cycle parasites differentiate and proliferate synchronously, paralleling the ver...
GSE95201: Gene expression profiles of liver and lung endothelial cells during normal and upregulation of Wnt/beta-catenin signaling
We genetically overexpressed a gain-of-function beta-catenin allele in liver and lung endothelial ce...
GSE94238: RNAseq analysis of B cells inducible for murine gammaherpesvirus 68 reactivation
RTA, the viral Replication and Transcription Activator, is essential for rhadinovirus lytic gene exp...
GSE94898: Heme and GATA1 coordinately regulate erythroid differentiation [RNA-seq]
In mice lacking the heme exporter, FLVCR, differentiation fails at the CFU-E/proerythroblast stage f...
GSE86909: NFIA regulates pancreatic cell fate and adult physiology through vesicle trafficking
Intracellular trafficking is essential for proper cell signaling. In the pancreas, secretory cells r...
GSE92887 (mouse): Impact of HypERrlnc Knockdown on the human pericyte transcriptome
Pericytes are essential for vessel maturation and endothelial barrier function. Long non-coding RNAs...
GSE90908: Characterization of meningeal type 2 innate lymphocytes and their response to CNS injury
The meningeal space is occupied by a diverse repertoire of innate and adaptive immune cells. CNS inj...
GSE96957: TWEAK mediates inflammation in experimental atopic dermatitis and psoriasis
Atopic dermatitis and psoriasis are driven by alternate type 2 and type 17 immune responses, but som...
GSE90891: Rb and p53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance
Prostate cancer relapsing from antiandrogen therapies can exhibit variant histology with altered lin...
GSE94018: Hippocampus-dependent learning and memory deficits by abnormalities in presynaptic plasticity in LSD1 knock-in mice
We examined the molecular and cellular mechanism for memory deficit in LSD1 knock-in mice. SOURCE: J...
GSE101629: Effects of Inhibition of CDK8/19 Mediator Kinase by Senexin B in HEK293 cells treated with or without TNF-alpha
We have investigated the effects of CDK8/19 inhibitor Senexin B on NFB-mediated transcription, induc...
GSE107868: RNA-sequencing and swarm intelligence-enhanced classification algorithm development for blood-based disease diagnostics using spliced blood platelet RNA
We report RNA-sequencing data of 80 tumor-educated blood platelet (TEP) samples isolated from 39 pat...
GSE128177: Skeletal Muscle Transcriptional Networks Linked to Motor Unit Remodeling in Human Parkinsons Disease
We performed transcriptional profiling to test the hypothesis that type I grouping severity in Parks...
GSE103949: Next Generation Sequencing for Quantitative Expression Analysis of Wild Type and Nrf1 deficient Liver Transcriptomes from Regular Diet (RD) or High Cholesterol Diet (CholD) fed mice
Purpose: Next-generation sequencing (NGS) for systematic analysis to discover Nrf1-dependent cellula...
GSE94902: Differential gene expression in IDH1-R132H low grade glioma animal brain tumors brain in response to 20 Gy of radiation
IDH1-R132H is expressed in Low Grade Glioma (LGG) in combination with loss of function mutation in A...
GSE92376: Gene expression profile of regulatory T cell (Treg) subsets from CD28-deficient mouse
A comparative analysis of gene expression of CD4+ EGFP+ Nrp1+ (tTreg, thymus-derived Treg), CD4+ EGF...
GSE112538: Spop restrains inflammation-induced emergency hematopoiesis by targeting MyD88 [Bulk RNA-Seq]
examination of the transcriptional profile of LSK and neutrophils (L6G+) SOURCE: Igor Dolgalev NYU L...
GSE96077: Genome Scale Analysis of miRNA and mRNA regulation during preterm labor [monocytes]
The goal of this study was to define relationships between peripheral blood miRNAs and mRNAs of wome...
GSE101511: HnRNPGT knockout disrupts pre-mRNA splicing and arrests sperm development prior to meiotic metaphase
Human male infertility has long been associated with genetic defects that affect nuclear RNA binding...
GSE102244: Zika Virus Has Oncolytic Activity against Glioblastoma Stem Cells
We explored the utility of oncolytic virus therapy against glioblastoma with Zika virus (ZIKV), a fl...
GSE108378: Exploring transcriptomic landscapes in red cell populations, in their extracellular vesicles and on single cell level
Circulating human red blood cells (RBCs) consist of mature erythrocytes, and immature reticulocytes....
GSE103124: Gene expression profiling of wild type and BMPR1a-deficient CD4+ T cells
The goal of this study was to compare transcriptome (RNA-seq) of activated Bone Morphogenic Protein ...
GSE108601: RNA sequencing for transcriptome comparison between HTLV-1 Tax(-) and Tax(+) cells in Adult T-cell leukemia cell lines (MT-1 and KK-1)
Initially, ATL cell lines (MT-1 or KK-1) were stably transfected with reporter plasmid for HTLV-1 T...
GSE140487: Expression profiling of Tex15 wt, Tex15 ht and Tex15 ko germ cells
We repport the effect of Tex15 inactivation on the transcriptome of male germ cells at embryonic day...
GSE117664: Stage-specific transcriptome analysis during differentiation from pluripotency to glial restricted progenitor stages
The goals of this study are to compare NGS-derived neural transcriptome profiling (RNA-seq) and to i...
GSE107885: Mta2, a component of the NuRD complex, regulates B cell development and cooperates with OCA-B in controlling the pre-B to immature B cell transition (RNA-Seq)
The goal of this study is to compare NGS-derived mouse B cell RNA profiling in Mta2 KO, Ocab KO, and...
GSE117590: Mouse gonadal transcriptome at 12.5dpc, 13.5dpc, 16.5dpc and 6dpp.
we employed RNA-Seq to examine transcriptome profiles of male and female mouse gonads at 12.5dpc, 13...
GSE92761: Multiple mechanisms of global microRNA suppression in vertebrate oocytes [RNA-seq]
Mouse oocyte maturation, fertilization, and reprogramming occur in the absence of transcription and ...
GSE101521: Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide
Brain gene expression profiling studies of suicide and depression using oligonucleotide microarrays ...
GSE107980: RING-finger protein 6 amplification activates JAK/STAT3 pathway by modifying SHP-1 ubiquitylation and associates with poor outcome in colorectal cancer
To elucidate whether RNF6 plays a role in colorectal cancer tumorigenesis, a RNA-seq analysis was ...
GSE99924: 4sU-seq analysis of Xist-mediated chromosomal silencing
The Polycomb repressive complexes PRC1 and PRC2 play a key role in chromosome silencing by Xist RNA....
GSE134419: Transcriptomic characterization of CRISPR/Cas9-edited THP1 cells to test the effect of disrupting the 3q23 genomic region containing TB-risk associated variants marking a putative monocyte-specific enhancer
We applied CRISPR/Cas9 technology to introduce insertions/deletions around the top associated varian...
GSE126109: RNA sequencing analysis of selumetinib-resistant CRC cells lines
RNA sequencing analysis to compare parental colorectal cancer cell lines and their selumetinib-resis...
GSE87450: Renal Fanconi syndrome and hypoposphatemic rickets in mice deficient for retroviral receptor XPR1 in the nephron
Tight control of both extracellular and intracellular inorganic phosphate (Pi) levels is critical to...
GSE110971: Sm eggs Virtual memory T cells
Transcriptomics analysis of virtual memory CD8+ T cells after treatment with Schistosoma mansoni egg...
GSE83720: Atr maintains chromosomal integrity during postnatal cerebellar neurogenesis [RNA-Seq]
Microcephaly and medulloblastoma result from mutations that compromise genomic stability. We report ...
GSE107060: Transcriptomic analysis of mouse embryonic stem cells during early differentiation and the effect of mTORC1 regulators knockout
This study analysed the transcriptome of mouse Rex1GFPd2 cells before and during early differentiati...
GSE109431: Transcriptional analysis of adult LRH-1 knockout livers reveals a novel role for LRH-1 in hepatic lipid homeostasis and phospholipid remodeling
Purpose: To identify novel LRH-1 target genes in adult knockout livers. SOURCE: Diego Miranda (diego...
GSE84234: Epigenetic restriction of embryonic and extraembryonic lineages mirrors the somatic transition to cancer (RNA-seq)
Concerted efforts over past decades have established a thorough understanding of the canonical somat...
GSE113075: Exacerbated S. aureus foot infections in obese/diabetic mice are associated with impaired germinal center reactions, Ig class-switching, and humoral immunity.
Seq. of popliteal l/n of obese and lean mice 3 months after HF feeding SOURCE: Christopher,W,Farnswo...
GSE108356: Epigenetic regulation of brain region-specific microglia clearance activity
The rapid elimination of dying neurons and non-functional synapses in the brain is carried out by mi...
GSE93918: Gene expression patterns after chronic clozapine in wild type mice and HDAC2 conditional knock-outs
Effect of chronic clozapine in the gene expression in the prefrontal cortex of wild type mice and mi...
GSE100148: ATRX mutant neuroblastoma is sensitive to EZH2 inhibition via modulation of neuronal differentiation
We report on the characterization of ATRX in-frame fusion neuroblastoma and identify that ATRX IFF p...
GSE108362: Spontaneous DIPG Modeling Reveals Novel H3.3 K27M-Mediated Oncogenic Mechanisms Acting Through Epigenetic Effects [RNA-seq]
A mouse knock-in model engineered for Cre recombinase-activated expression of the endogenous mouse H...
GSE101712: Single cell RNA-sequencing of Mbd3-null and control lymphoid progenitor cells
To determine the role of Mbd3/NuRD in lymphopoiesis, gene expression in single Mbd3-deleted and cont...
GSE108359: Repression of Ect2 induces cytokinesis failure and decreases heart muscle cell proliferation in congenital heart disease
Proliferation of heart muscle cells (cardiomyocytes) is the basis for heart development and regenera...
GSE94408: Epigenetic mechanisms underlie the crosstalk between growth factors and a steroid hormone [IMR90_MCF7_RNA-Seq]
Growth factors (GFs) suppression by steroid hormones recurs in embryology and is co-opted in pathol...
GSE115503: RNA-Seq analysis of skin from bleomycin induced scleroderma murine models treated with EHP-101
Systemic sclerosis (SSc) or scleroderma is a chronic multiorgan autoimmune disease of unknown etiolo...
GSE83506: Ezh2 Inhibition is Bone-anabolic and Osteoprotective in Skeletally Mature Mice
We report genome-wide effects of Ezh2 inhibition (GSK126) in MC3T3 sc4 pre-osteoblasts by ChIP-Seq (...
GSE95243: Transcriptomes of iPSC-derived and post-mortum Hypothalamus Neurons from obese and control donors
We sequenced the transcriptomes of seven samples of hypothalamic neurons dervied from pluripotent st...
GSE92874: Genome-wide transcriptome profiles in Control and Schizophrenia hiPSC-dervied NPC [RNA-seq]
We Report the genome-wide RNA expression levels in control and schizophrenia hiPSC dervied NPC treat...
GSE127522: Young and Old Mouse Parabiosis Hematopoietic Stem Cell RNA Sequencing
RNA sequencing of hematopoietic stem cells isolated from young (8-12 week) and old (24-27 month) BL6...
GSE102305: Strand-oriented RNAseq of LNCaP prostate cancer cells in culture for 24h in the presence of androgen
The aim of this study was to use NGS RNAseq deep-sequencing in order to characterize the polyadenyla...
GSE114382: First Clinical Study Targeting ROR1, A Cancer Stem Cell Antigen Involved In Rho-GTPase Activation
Cirmtuzumab is a humanized monoclonal antibody that selectively targets ROR1, which is expressed on ...
GSE112594: Elevated T cell levels in peripheral blood predict poor clinical response following rituximab treatment in new-onset type 1 diabetes
Peripheral blood samples were collected from subjects enrolled in the TrialNet study TN-05. This was...
GSE111079: Characterization of murine hepatoma cells with regard to their dependence on cyclin E1
In C57BL/6 mice with a floxed cyclin E1 (CcnE1) gene (CcnE1f/f), hepatocellular carcinomas were indu...
GSE112586: RNA transcriptome sequencing analysis of SGC-7901 cells transfected with ENST00000431060 shRNA or control shRNA
RNA transcriptome sequencing analysis was performed in SGC-7901 cells that were transfected with ENS...
GSE131397: Systematic evaluation of RNA-Seq preparation protocol performance (RNASeq: TruSeq)
In this study, we present a comprehensive evaluation of four RNA-Seq library preparation methods. We...
GSE83897: Transcriptomes analysis of mammary tumors induced by overexpression of the Ret receptor tyrosine kinase from a new transgenic mouse model
Model: The activation of Ret receptor tyrosine kinase regulates mammary tumor growth, tumor-associat...
GSE103840: Single-cell RNA sequencing of sensory neurons in the mouse dorsal horn
We have used large-scale single-cell RNA sequencing (RNA-seq) to classify sensory neurons in the mou...
GSE95837: Single cell gene expression in Dlxi1/2b::eGFP+ cells before and after migration, 4 weeks
We report the expression of selected genes associated with cortical, striatal and olfactory interneu...
GSE108446: Gene expression profile for B6 wild-type and B6 Bgn gene knockout mice (Bgn0/-) with and without fructose treatment by RNA-Seq
To investigate the effects of fructose on affecting the gene expressions in the hippocampus of male ...
GSE109083: Transcriptomic analysis of microglia from 7 week Npc1 disease mouse model treated or not with 4000mg.kg-1 HPBCD
the study aims to describe the modifications occurring the microglia isolated from NPC1 disease mous...
GSE83931: Sex differences in the molecular signature of the developing mouse hippocampus
A variety of neurological disorders, including Alzheimers disease, Parkinsons disease, major depress...
GSE112591: Gene expression signatures of innate lymphoid cells from human blood
We aimed to determine the characteristic of 3 different ILC subsets (ILC1, 2 and 3) isolated from hu...
GSE112609: RNA-seq data from double positive thymocyte and CD4 or CD8 single positive spleen T cell
Control RNA-seq data for thymocyte and spleen T cell. SOURCE: kiyokazu kakugawa (kiyokazu.kakugawa@r...
GSE90890: Osteoblast-specific deletion of Hrpt2/Cdc73 results in high bone mass and increased bone turnover
RNA-seq within OCN-Cre;Cdc73flox/flox osteoblasts showed that loss of Cdc73 led to a derepression of...
GSE90950: RNA-Seq of human PDA cell lines transfected with control siRNA or Pdx1 siRNA
We compared the transcriptome of four human PDA lines: HPAF-II, Panc.05.04, Panc.8 and Panc.10.05 tr...
GSE109447: Single-cell gene expression data from Ventricular-Subventricular Zone (V-SVZ) cells
We performed large-scale single cell profiling of V-SVZ cells, following separate dissections of the...
GSE119931: Cell differentiation grade determines distinct FOXA2 contributions to the cis-regulatory networks of pancreatic cancer cells [RNA-seq]
Abnormal differentiation contributes to the spectrum of aberrant properties of tumor cells. Differen...
GSE112095: Role of SmcHD1 in the establishment of the epigenetic states required for the maintenance of X chromosome inactivation [RNA-seq]
It has been shown that functional deficiency of SmcHD1, a noncanonical member of SMC family proteins...
GSE107910: Single-cell RNA sequencing resolves cellular heterogeneity throughout embryonic development of the thymus
This dataset consists of single-cell RNA-seq (Drop-seq) data from eight days of mouse thymus develop...
GSE111545: Invasive non-typhoidal Salmonella dysregulates the repertoire of dendritic cell responses to intracellular and extracellular stimuli [bulk RNA-seq]
Non-typhoidal Salmonella (NTS) are among of the most important food-borne pathogens. Recently, a hig...
GSE84703: Chromatin remodelling factor SMARCD2 (BAF60B) regulates transcriptional networks controlling early and late differentiation of neutrophil granulocytes
Differentiation of haematopoietic stem cells followsa hierarchical program of transcription-factor r...
GSE109294: Transcriptome of Dp1Tyb and wild-type mouse hippocampus
Purpose: to identify the effects of the Dp1Tyb mutation on the transcriptome of mouse hippocampus SO...
GSE93650: Genome-wide mapping of DROSHA cleavage sites on primary microRNAs and novel substrates [RNA-seq]
MicroRNA (miRNA) maturation is initiated by DROSHA, a double-stranded RNA (dsRNA)-specific RNase III...
GSE101458: ILC1 lineage identity is determined by a cis-regulatory element marked by a novel lncRNA [RNA-seq]
Innate lymphoid cells (ILCs) comprise three groups of recently identified tissue resident immune cel...
GSE99933: Multipotent Peripheral Glial Cells Generate Neuroendocrine Cells of the Adrenal Medulla
Cells producing adrenalin are largely derived from nerve-associated Schwann cell precursors via an i...
GSE108464: 4 NSCLC cell lines treated with GDC-0973, AZ-628 or a combination of both
RNA was purified cancer cell lines. The "SAMPLE_ID" sample characteristic is a sample identifier int...
GSE108743: The mRNA expression analysis of mesenchymal stem cell from psoriasis skin lesion
mRNA sequencing for 6 samples of skin-derived mesenchymal stem cells from either normal skin or psor...
GSE103143: The mechanism of HHT in treating acute myeloid leukemia on RNA level.
Through the GSEA analysis, we identified the suppressed E2F targets, G2M checkpoints, and hyperactiv...
GSE111709: Molecular and Functional Characterization of Disease-Propagating Stem Cells in Juvenile Myelomonocytic Leukemia [FACS sorted populations]
We report on the characterization of JMML hematopoietic stem and progenitor cells (HSPCs). In orde...
GSE108972: PEST-domain-enriched tyrosine phosphatase and glucocorticoids as regulators of mast cell signalling
PEST-domain-enriched tyrosine phosphatase (PEP) is a cytoplasmic protein tyrosine phosphatase that r...
GSE93863: Differential Expression of the Transcription Factor GATA3 Specifies Lineage and Functions of Innate Lymphoid Cells
Lymphoid tissue inducer (LTi) cells are regarded as a subset of innate lymphoid cells (ILCs). Howeve...
GSE111727: Single-Cell RNA-Seq Reveals Transcriptional Heterogeneity in Latent and Reactivated HIV-infected Cells
Despite effective treatment, HIV can persist in latent reservoirs, which represent a major obstacle ...
GSE115357: FBXO11-Mediated Proteolysis of BAHD1 Relieves PRC2-dependent Transcriptional Repression in Erythropoiesis
The histone mark H3K27me3 and its reader/writer Polycomb repressive complex 2 (PRC2) mediate widespr...
GSE84592: Artemisinins target GABAA receptor signaling and impair alpha cell identity
Type 1 diabetes is characterized by the destruction of pancrea tic beta cells, and generating new...
GSE92891: Impact of control interventions on lung gene expression in post-natal lung development
During the studies of post-natal lung development in the laboratory C57BL/6 mouse, broad spectrums o...
GSE94919: Chemoprevention with COX2 and EGFR inhibition in FAP patients: mRNA signatures of duodenal neoplasia
RNA sequencing of duodenal polyps in FAP patients treated with plabebo or the drug combination, erlo...
GSE97353: Comparison of scAAV9-CA and scAAV9-U6 driven artificial miRNAs targeting human huntingtin
Huntingtons disease is a devastating, incurable neurodegenerative disease affecting up to 12 per 100...