PLX282410

GSE134419: Transcriptomic characterization of CRISPR/Cas9-edited THP1 cells to test the effect of disrupting the 3q23 genomic region containing TB-risk associated variants marking a putative monocyte-specific enhancer

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

We applied CRISPR/Cas9 technology to introduce insertions/deletions around the top associated variant rs73226617. Among 23 single-cell sorted and expanded clones that had unchanged 3q23 genomic region with the risk locus (i.e. wildtype), or harbored unique edits and deletions around rs73226617. SOURCE: Yang Luo (yangluo@broadinstitute.org) - Harvard Medical School

View on GEOView in Pluto

Key Features

Enhance your research with our curated data sets and powerful platform features. Pluto Bio makes it simple to find and use the data you need.

Learn More

14K+ Published Experiments

Access an extensive range of curated bioinformatics data sets, including genomic, transcriptomic, and proteomic data.

Easy Data Import

Request imports from GEO or TCGA directly within Pluto Bio. Seamlessly integrate external data sets into your workflow.

Advanced Search Capabilities

Utilize powerful search tools to quickly find the data sets relevant to your research. Filter by type, disease, gene, and more.

Analyze and visualize data for this experiment

Use Pluto's intuitive interface to analyze and visualize data for this experiment. Pluto's platform is equipped with an API & SDKs, making it easy to integrate into your internal bioinformatics processes.

Read about post-pipeline analysis

View QC data and experiment metadata

View quality control data and experiment metadata for this experiment.

Request import of other GEO data

Request imports from GEO or TCGA directly within Pluto Bio.

Chat with our Scientific Insights team