PLX026532

GSE109908: RNA seq from liver samples of C57BL/6 mice to study the gene expression synchrony of Plasmodium stages with host circadian cycle.

• Organsim mouse
• Type RNASEQ
• Target gene
• Project ARCHS4

The Plasmodium life cycle parasites differentiate and proliferate synchronously, paralleling the vertebrate host's circadian rhythm. Here we report that expression of carbohydrate metabolism and inflammatory genes in IFN-primed leukocytes and liver cells from infected mice are boosted in P. chabaudi-infected mice. In addition, a rhythmic gene expression of PPARG and TNF, which are key regulators of glucose metabolism, parallel blood glucose levels across the circadian cycle in infected mice. SOURCE: Ricardo,Tostes,Gazzinelli (ricardo.gazzinelli@umassmed.edu) - Infectious Diseases and Immunology University of Massachusetts Medical School