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Sequencing-based assays (Page 1)
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GSE54154: RNA-seq analysis of diabetes induced changes in macrophage transcriptome
Macrophage dysfunction and polarization plays key role in chronic inflammation associated with diabe...
GSE125387: RNA-seq of three group mice in hippocampus.
We reported a 28-day Intermittent fasting (IF) regimen improved cognitive deficits in db/db mice via...
GSE125769: Point mutations in the PDX1 transactivation domain impair human -cell development and function (RNA-Seq)
Missense mutations in coding region of PDX1 predispose to type-2 diabetes mellitus as well as cause ...
GSE83139: Single cell RNA-seq of human pancreatic endocrine cells from Juvenile, adult control and type 2 diabetic donors.
We successfully sequenced and annotated more than 400 cells from child, adult control, type 1 diabet...
GSE106180: Stable oxidative cytosine modifications accumulate in cardiac mesenchymal cells from Type2 diabetes patients: rescue by alpha-ketoglutarate and TET-TDG functional reactivation [mouse heart RNA-seq]
Background: Here, the role of -ketoglutarate (KG) in the epi-metabolic control of DNA demethylation ...
GSE116369: Discovering human diabetes-risk gene function with genetics and physiological assays
To delineate the effects of BCL11A (a type 2 diabetes risk gene) in human beta cell function we knoc...
GSE77652: FoxO1 Deacetylation Decreases Fatty Acid Oxidation in beta-cells and Sustains Insulin Secretion in Diabetes
Pancreatic beta-cell dysfunction contributes to onset and progression of type 2 diabetes. In this st...
GSE80162: Genetic identification of an adipocyte expressed anti-diabetic target in mice selected for resistance to diet-induced obesity
Discovery of genetic mechanisms of resistance to obesity and diabetes may illuminate new therapeutic...
GSE69201: Genome wide transcriptional alterations during post-infarct remodeling in type 2 diabetic mice.
The cellular and molecular aspects of post-infarct left-ventricle remodeling in presence of type-2 d...
GSE108971: Novel Atherogenic Pathways from the Differential Transcriptiome Analysis of Diabetic Epicardial Adipose Tissue
In this study we performed transcriptome sequencing on the Subcutaneous Adipose Tissue and Epicardia...
GSE110648: The Polycomb-dependent epigenome controls -cell dysfunction, dedifferentiation and diabetes
To date, it remains largely unclear to what extent chromatin machinery contributes to the susceptibi...
GSE77717: RNA-Seq of Kidney Glomeruli from Type 2 diabetic (db/db) and non-diabetic mice
We investigated the gene expression profiles of RNA isolated from kidney glomeruli from aged, 25 wee...
GSE92724: Dermal endothelial cells of type 2 diabetic patients
The prevalence of type 2 diabetes mellitus (T2D) is increasing constantly and various risk factors s...
GSE121344: A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism: Liver RNA profiles of lean non-diabetic, obese non-diabetic as well as obese diabetic humans.
Obesity and type 2 diabetes mellitus are global emergencies and long noncoding RNAs (lncRNAs) are re...
[GSE144706] Gene regulation by gonadal hormone receptors defines brain sex differences
[GSE144716] Gene regulation by gonadal hormone receptors defines brain sex differences
[GSE144717] Gene regulation by gonadal hormone receptors defines brain sex differences
Next generation sequencing of distal colon glial cells with DNBS-induced inflammation and neurokinin-2 receptor antagonism utilizing RiboTag mice (GSE114780)
Purpose: We have the first-reported set of glial-specific transcripts utilizing the Ribotag model. W...
[GSE181204] Estrogen Drives Melanocortin Signaling to Increase Spontaneous Activity
[GSE227179] Engineered exosomes reprogram Gli1+ cells in vivo to prevent calcification of vascular grafts and autologous pathological vessels
[GSE122747] Identification of cis-regulatory elements affecting pancreatic Islet maturation using chromatin accessibility variations
[GSE159265] H2AK119ub1 ChIP-seq in rat peripheral nerve
GSE168846: Molecular Determinants of Response to Anti–PD-1 Immunotherapy in Syngeneic Tumor Mouse Models
GSE245574: Disrupted RNA editing in beta cells mimics early-stage type 1 diabetes
GSE199978: A novel somatic mutation in GNAQ in Sturge-Weber Syndrome provides insight into disease pathogenesis
TCGA BLCA tumors by stage and MSH2 expression
[GSE233691] Rewiring of the epigenome and chromatin architecture by retinoic acid signaling during zebrafish embryonic development [ATAC-seq]
[GSE233689] Rewiring of the epigenome and chromatin architecture by retinoic acid signaling during zebrafish embryonic development [RNA-seq]
[GSE184946] RNA-seq analysis for IRF4-driven zebrafish tumors after JQ1 treatment
[GSE166644] H3K27ac ChIP-seq analysis for zebrafish normal thymus and tumors driven by overexpression of human IRF4
GSE37236: Gene expression analysis of murine SAMHD1 deficient peritoneal macrophages
To elucidate responses of myeloid cells to SAMHD1 deficiency in the absence of exogenous viral infec...
GSE57982: Transcriptome profiling in human T-ALL
Genome-wide mapping and characterization of novel Notch-regulated long non-coding RNAs in acute leuk...
GSE39509: Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell of origin model for prostate cancer heterogeneity
We used RNA-seq to compare the expression profiles of mouse prostate tumors originated from epitheli...
GSE58724: Oxymetholone therapy of Fanconi anemia suppresses osteopontin transcription and induces hematopoietic stem cell cycling
We used Fancd2-/- mice to understand its mechanism of action. Transcriptome analysis of cKit+ Sca1+ ...
GSE50775: Role of de novo DNA methyltransferases in hematopoietic stem cells (RNA-seq)
To investigate the global transcriptome expression in Dnmt3ab dKO HSCs, we performed high-throughput...
GSE65444: Expression and transcriptional regulation dynamics of hepatic lincRNAs
Gene expression in adult male and female mouse liver was assayed by RNA-seq, as part of a study on h...
GSE40522: ENCODE PSU Hardison RnaSeq
This data was generated by ENCODE. If you have questions about the data, contact the submitting labo...
GSE49642: Leucegene: AML sequencing
RNA sequencing of human leukemia SOURCE: Guy Sauvageau Institute for Research in Immunology and Canc...
GSE45657: AA Effector CD8 T cell profiling
Flow sorted CD3+CD8+CD44+CXCR3+NKG2D+ lymph node cells from C3H/HeJ mice with alopecia were flow sor...
GSE46730: Transcriptome Analysis of LincRNA TUNA Knockdown in Mouse Embryonic Stem Cells
Globel gene expression was analyzed by RNA-seq to study the role of lincRNA TUNA in pluripotent mous...
GSE153132: Combinatorial transcriptional profiling of mouse and human enteric neurons identifies shared and disparate subtypes in situ [Mouse nuclei bulk RNA-Seq]
The data provided here were used to generate a comprehensive transcriptome atlas for the enteric neu...
GSE65830: Cas9 nuclease guide RNAs for genome-wide knockout of long intergenic noncoding RNAs
RNA-seqs followed by whole and segmental deletions of XIST genes in human K562 cells. SOURCE: Hyeon,...
GSE55188: RNA-Seq of Aged Polg Mutator Mouse Brains
We have performed both proteomic and transcriptomic analyses of the brains of one-year old Polg muta...
GSE57602: RNAseq analysis of mouse lung transcriptome from allergic and non-allergic mice prior to and following lung Klebsiella pneumoniae infection
We have demonstrated that allergic airway inflammation (induced by an ovalbumin sensitization and ae...
GSE35350: Combined miRNA and mRNA Sequencing Identifies Protective Transcriptional Signature of Enhanced PI3Kalpha Signaling in Cardiac Hypertrophy
A molecular and bioinformatic pipeline permitting comprehensive analysis and quantification of myoca...
GSE39756: BATF-JUN is critical for IRF4-mediated transcription in T cells
Interferon regulatory factor 4 (IRF4) is an IRF family transcription factor with critical roles in l...
GSE18927: University of Washington Human Reference Epigenome Mapping Project
The NIH Roadmap Epigenomics Mapping Consortium aims to produce a public resource of epigenomic maps ...
GSE34903: Gene expression profiles of tumor-associated macrophages (TAMs) overexpressing miR-511-3p
Hematopoietic stem/progenitor cells (HS/PCs) were transduced with lentiviral vectors overexpressing ...
GSE148137: Nalm 6 WT; Nalm6 BKO; Nalm 6 A hets
Four replicas of cells with and without TOP2B and cells heterozygous for TOP2A SOURCE: John Casement...
GSE36290: High-throughput sequencing of sequentially reprogrammed iPS cells reveals key epigenetic modifications correlated with reduced pluripotency of iPS cells [RNA-seq]
Full pluripotency of induced pluripotent stem (iPS) cells has been determined as viable all-iPS mice...
GSE42912: Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons
Nurr1 (Nr4a2, nuclear receptor subfamily 4 group A member 2) is needed for the development of ventra...
GSE149327: RNA-sequencing analysis of tumor-infiltrating B cells
Tumour-infiltrating lymphocytes are a major predictor for overall survival and response to immunothe...
GSE46700: AID stabilizes a stem cell phenotype by removing epigenetic memory of secondary pluripotency network genes
The activation-induced cytidine deaminase enzyme (AID) is required in germinal center (GC) B cells f...
GSE55808: Identification of genes associated with TGF-beta/Smad3-mediated renal inflammation and fibrosis by RNA sequencing
In this study, we employed high-throughput RNA sequencing (RNA-Seq) to identify the Smad3-dependent ...
GSE36552: Tracing pluripotency of human early embryos and embryonic stem cells by single cell RNA-seq
Find the casual relationship between gene expression network and cellular phenotype at single cell r...
GSE41908: Transcriptome profiling of wild type primordial germ cells (PGC) by RNAseq
Purpose: To identify molecular pathways underlying epigenetic reprogramming in early germ cell precu...
GSE38808: The Transcription Factor T-bet Is Induced by Multiple Pathways and Prevents an Endogenous Th2 Cell Program during Th1 Cell Responses
T-bet is a critical transcription factor for T helper 1 (Th1) cell differentiation. To study the reg...
GSE65831: RNA-sequencing of tumor-associated microglia reveals Ccl5 as a stromal chemokine critical for neurofibromatosis-1 glioma growth
GSE143142: Transcriptome Analyses of Pulmonary Interstitial Macrophages derived from Hypoxic Cx3cr1cre;Hif1 (/) vs. Hif1f (flox/flox) Mice
To determine roles by which infiltrating pulmonary intersitial macrophages regulate development and ...
GSE41293: Mouse Model of Clear Cell Sarcoma
Profile gene expression from tumors that develop in mice bearing conditional activation of EWS-ATF1,...
GSE57478: Treatment of multiple myeloma cells with EZH2 small molecule inhibitor
We investigated differential gene expression in response to treatment of multiple myeloma cells with...
GSE57494: GPBAR1 agonism has a broad impact on blocking macrophage activation
Human D14+ / CD16+ monocytes were treated with GPBAR1 agonists or controls, and were stimulated wit...
GSE38233: Study functions of ADAR proteins using next generation sequencing of genome and transcriptome
Adenosine deaminases, RNA specific (ADAR) are proteins that deaminate adenosine to inosine which is ...
GSE38892: Analysis of Pro-Inflammatory Gene Activation and RNA Processing by RNAseq of Nascent Transcripts [supplement]
Note: These datasets are in supplement to, but separate from, Geo GSE32916. We examined pro-inflamma...
GSE53627: Disruption of H3K27me3 through loss of EZH1 and EZH2 accelerates progression of hepatosteatosis to fatal liver fibrosis
Although epigenetic mechanisms, such as specific histone modifications, control common and cell-spec...
GSE123760: HDAC and NFB antagonists synergistically inhibit growth and metastatic dissemination of MYC-driven medulloblastoma
Aberrant oncogenic activation of MYC drives tumorigenesis in the most aggressive subset of medullobl...
GSE36463: Profiling of differential allelic expression in mouse placental tissues from two reciprocal crosses at embryonic day 13.5 and 17.5.
Mammals achieve parity in expression of X linked genes in somatic tissue of males and females throug...
GSE40918: A validated regulatory network for Th17 cell specification
Th17 cells have critical roles in mucosal defense and are major contributors to inflammatory disease...
GSE43631: next generation sequencing facilitates quantitative analysis of control and TKO liver transcriptomes
We used RNAseq to analyse the transcriptomes of cycling and quiescent livers from cTKO (Rblox/lox;p1...
GSE116188: Transcriptional profiling of WM1976 cells with siRNA knockdown of the long non-coding RNA SLNCR
RNA-Seq was used to profile transcriptional changes induced by siRNA knockdown of the long non-codin...
GSE95500: Celecoxib, Rofecoxib Chronically Treated Mice, with IL1beta, Aorta RNA-Seq
We screen for vascular off-target effects at therapeutic concentrations of celecoxib and rofecoxib u...
GSE57397: Transriptional profiling upon heat shock and recovery in cells deficient for FBXW7 and their wild type counterpart.
FBXW7 modulates stress response by post-translational modification of HSF1; HSF1 orchestrates the he...
GSE41879: Gene expression analysis of murine SAMHD1 deficient peritoneal macrophages (S1056 to S1075)
To elucidate responses of myeloid cells to SAMHD1 deficiency in the absence of exogenous viral infec...
GSE41586: Expression data for HT29 cells treated with 5-aza-deoxy-cytidine [RNA-Seq]
The RNA samples from HT-29 (ATCC) colon cancer cell line were reverse transcribed to build cDNA libr...
GSE63570: High-throughput sequencing of pluripotent cells
We report HERV-K rec iCLIP-seq binding data, ribosome profiling data, and RNA-seq from ELF1 nave hES...
GSE40291: Efficient direct reprogramming of c-Kit mature amniotic cells into endothelial cells by ETS factors and TGF suppression
ETS transcription factors ETV2, FLI1 and ERG1 specify pluripotent stem cells into endothelial cells ...
GSE39160: Loss of Ikaros tumor suppressor function in a mouse model of BCR-ABL1-induced B-ALL correlates with a developmental block at a highly proliferative stage
Deletions within the human IKZF1 gene, which encodes Ikaros, a zinc finger transcription factor crit...
GSE42878: Pregnancy-induced gene expression and differentiation of mouse mammary epithelium are co-governed by Nuclear Factor IB (NFIB) and STAT5
Cytokines control the expression of common and cell-specific genes through the transcription factor ...
GSE155887: RNA sequencing of CEA-TCB (cibisatamab)-treated and untreated tumors derived from MKN-45 tumor-bearing humanized mice
These experiments were done as part of a larger study that investigated the mode of action of T-cell...
GSE38741: The Folliculin-Fnip1 pathway deleted in human Birt-Hogg-Dube syndrome is required for B cell development.
Birt-Hogg-Dube (BHD) syndrome is an autosomal dominant disorder characterized by hamartomas of skin ...
GSE57391: RNA-seq profiling of gene expression in Ezh2-deficient and control murine lung epithelial and stromal cell populations at day E16.5
Epithelial (CD31-CD45-EpCAM+) and stromal (CD31-CD45-EpCAM-) lung cells were derived by FACS from Sh...
GSE47019: Developmentally Abnormal Human Embryos Trigger a Maternal ER Stress Response
Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular path...
GSE39129: A TLR- and non-TLR-mediated innate response to lentiviruses restricts hepatocyte entry and can be ameliorated by pharmacological blockade
Lentiviral vector (LV)-mediated gene transfer is a promising method of gene therapy. We previously r...
GSE42268: Quartz-Seq: a simple and highly quantitative method for single-cell RNA-Seq
We report novel single-cell RNA-Seq, called Quartz-Seq. Quartz-Seq was simplified method compared wi...
GSE45049: An Ancient Transcription Factor Initiates the Burst of piRNA Production During Early Meiosis in Mouse Testes (smallRNA-Seq)
Animal germ cells produce PIWI-interacting RNAs (piRNAs), small silencing RNAs that suppress transpo...
GSE43028: Small and large RNA sequencing of a Kras G12D mouse model of lung adenocarcinoma
Mice bearing a G12D activating mutation in Kras consistently develop lung adenocarcinomas in a manne...
GSE47042: Discovery of the p53 targetome in MCF7 cells from RNA-seq data
RNA-seq and ChIP-seq on MCF-7 breast cancer cell line upon activation of p53 by the non-genotoxic sm...
GSE42339: RNA-Seq expression data from the reproductive tracts of WT, Hoxa91011, and Hoxd91011 mutant mice
Hox genes are key regulators of development. In mammals, the study of these genes is greatly confoun...
GSE58732: MEIS1-HLF axis regulates oxidative metabolism and is essential for MLL-fusion gene leukemia
The pathogenesis of MLL-fusion gene leukemias has been linked to upregulated expression of HOX genes...
GSE41974: Transcriptome analysis in mouse early round spermatids deficient in pachytene piRNAs (Miwi+/- and -/-)
In animal germline cells, Piwi-interacting RNAs (piRNAs) silence retrotransposons through post-trans...
GSE40064: H2AZ extended acidic patch is necessary for formation specialized chromatin states in ESCs [RNA-Seq]
The H2A variant H2AZ is essential for embryonic development and for proper execution of developmenta...
GSE45180: Gene expression data from CD11b-positive myeloid cells infiltrating tumors after local irradiation
Analysis of global gene expression in myeloid cells infiltrating tumors after irradiation. Cell deat...
GSE50708: Identification of genes regulated by Rcor1 in CD71+, TER119- erythroid progenitors using mRNA-seq analysis
Transcription cofactor Rcor1 has been linked biochemically both to neurogenesis and hematopoiesis. H...
GSE39656: Braveheart is a long non-coding RNA necessary for cardiac lineage commitment
Purpose: Long non-coding RNAs (lncRNAs) display development-specific gene expression patterns, yet w...
GSE53080: Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers [small RNA-seq]
Heart failure is associated with high morbidity and mortality and its incidence increases worldwide....
GSE57092: Suv39h-dependent H3K9me3 represses intact retrotransposons in mouse embryonic stem cells
Heterochromatin is required to restrict aberrant expression of retrotransposons, but it remains poor...
GSE44665: Genome wide RNA-seq analysis of E9.5 Smchd1 wild type and mutant embryos
We report the deregulation of expression in E9.5 male mouse embryos are that homozygous for a mutant...
GSE109152: Integrated approach reveals diet, APOE genotype and sex affect immune response in APP mice
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that is influenced by geneti...
GSE66870: MeCP2 binds to mCH as neurons mature, influencing transcription and onset of Rett syndrome [mRNA-Seq]
The postnatal neurodevelopmental disorder Rett syndrome (RTT) is caused by mutations in the gene enc...
GSE46104: Global transcriptome profiling of Oct4/Klf4/Sox2 (3Factor, 3F) + IL6 iPS clones derived from mouse embryonic fibroblasts.
We used heterokaryon cell fusion based reprogramming and identified the cytokine IL6 as a potential ...