PLX087406

GSE99437: AP4 regulates stem and Paneth cell homeostasis and promotes adenoma initiation in the intestine (adenoma)

Organsim mouse
Type RNASEQ
Target gene
Project ARCHS4

AP4 is frequently expressed in primary CRCs. However, the in vivo relevance of AP4 for development of intestinal tumor formation has not been analyzed by genetic approaches. ApcMin/+ mice with deletion of AP4 were generated and analyzed. The mRNA expression profiles of intestinal adenomas with and without functional AP4 were compared. SOURCE: Markus Kaller (markus.kaller@med.uni-muenchen.de) - Experimental and Molecular Pathology Ludwig-Maximilians-University Munich

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