PLX324768

GSE99250: Kmt2a and Kmt2b Control Memory Function via Different Transcriptional Programs

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

We have analyzed changes in histone 3 lysine 4 methylation (H3K4me) and gene expression resulting either from Kmt2a or Kmt2b knockdown in adult hippocampal CA neurons in mice. We implemented Cre/loxP-mediated conditional knockout strategy in order to knockdown either of these histone methyltransferases in excitatory forebrain neurons in adult mice. SOURCE: Gaurav Jain (gauravj49@gmail.com) - The German Center for Neurodegenerative Diseases (German: Deutsches Zentrum für Neurodegenerative Erkrankungen DZNE)

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