PLX320543

GSE98724: Transcription factor-dependent anti-repressive mammalian enhancers exclude H3K27me3 from extended genomic domains

• Organsim mouse
• Type RNASEQ
• Target gene
• Project ARCHS4

To define and assess the role of transcription factor binding at villus enhancers, we performed ATAC-seq and ChIP-seq.; We used RNA-sequencing to profile gene expression changes upon transcription factor loss. Loss of gene expression correlated with transcription factor-dependent enhancers and reveal the role of certain enhancers in H3K27me3 exclusion. SOURCE: Ramesh Shivdasani (ramesh_shivdasani@dfci.harvard.edu) - Shivdasani Dana Farber Cancer Institute