PLX164888

GSE97544: Striatal transcriptome analysis of Shank3-overexpressing mice

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Shank3 is a core excitatory postsynaptic protein enriched in the striatum. We have previously generated and characterized Shank3-overexpressing transgenic mice, and found that these mice exhibited manic-like behavioral phenotypes. To understand molecular mechanisms underlying the behavioral changes, we performed transcriptome (RNA-sequencing) analysis of the striatal tissues from 12-week-old wild-type and Shank3 transgenic mice. SOURCE: Kihoon Han (neurohan@korea.ac.kr) - Korea University College of Medicine

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