PLX081277

GSE96777: ZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator [RNA-seq]

• Organsim human
• Type RNASEQ
• Target gene
• Project ARCHS4

Here we show that ZBTB48 binds directly both to telomeric as well as to subtelomeric variant repeat sequences. ZBTB48 is found at telomeres of human cancer cells regardless of the mode of telomere maintenance and it acts as a negative regulator of telomere length. In addition to its telomeric function, we demonstrate through a combination of RNAseq, ChIPseq and expression proteomics experiments that ZBTB48 acts as a transcriptional activator on a small set of target genes, including mitochondrial fission process 1 (MTFP1). This discovery places ZBTB48 at the interface of telomere length regulation, transcriptional control and mitochondrial metabolism. SOURCE: Sergi Sayols Institute of Molecular Biology, Mainz