PLX313949

GSE95712: Bmal1 regulates inflammatory response in macrophage

Organsim mouse
Type RNASEQ
Target gene
Project ARCHS4

Deletion of Arntl disrupted temporal inflammatory response in macrophage. Mechanistically, the acetylation status of lysine 27 of histone 3 (H3K27ac) was enhanced at the PU.1-containing enhancers in Arntl-/- macrophages compared to the wild-type cells. Collectively, transcription factor network containing Bmal1 controls temporal inflammatory response of macrophages by regulating epigenetic states of enhancers. SOURCE: Yumiko Oishi (yuooishi-circ@umin.ac.jp) - Tokyo Medical and Dental University

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