PLX172115

GSE89660: Comparison of gene expression patterns of two SCLC genetically-engineered mouse models; Rb1 floxed, Trp53 foxed, LSL-Myc T58A-IRES-Luc vs. Rb1 floxed, Trp53 foxed, RPR2 (p130) floxed

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Myc expression cooperates with Rb1 and Trp53 loss in mouse lungs to generate rapid, aggressive, highly metastatic and neuroendocrine-low tumors which are similar to human variant subset of SCLC with high NEUROD1 expression. Targeted drug screening reveals that mouse and human MYC-driven SCLC are vulnerable to Aurora kinase inhibition in combination with chemotherapy in vivo. SOURCE: Trudy Oliver (Trudy.Oliver@hci.utah.edu) - Oliver University of Utah

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