PLX249130

GSE85249: Wnt-responsive mesenchymal cells in dorsal back skin and ventral foot skin

Organsim mouse
Type RNASEQ
Target gene
Project ARCHS4

Canonical WNT-signaling is essential for placode formation irrespective of appendage type. At sites of placode initiation, Although WNT-signaling occurs in both epithelium and mesenchyme, the site of most intense activity as revealed by the WNT reporter Axin2-LacZ was in a zone just below the epithelial-mesenchymal interface. In ventral foot-skin, this WNT activity peaked at E17.5, concomitant with sweat bud fate commitment, while in dorsal back-skin, it began at E14.5, concomitant with HF fate specification. SOURCE: Catherine,Pei-ju,Lu (clu@rockefeller.edu) - Fuchs Lab Rockefeller University

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