PLX275092

GSE84620: Transcriptomic changes mediated by -amyloid in human aortic endothelial cells (HAOEC)

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

We found that -amyloid accumulation is modulated in HAOEC cells by overexpression or blocking of lncRNA BACE1-AS, which in turn regulates both BACE1 mRNA and protein expression. BACE1 is key-enzyme in the synthesis of -amyloid from Amyloid Precursor Protein (APP). The transcriptomic changes mediated by 400nM -amyloid was investigated in HAOEC cells. SOURCE: Fabio Martelli (fabio.martelli@grupposandonato.it) - Molecular Cardiology IRCCS-Policlinico San Donato

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