PLX100198

GSE83785: Hormone induced repression of genes requires BRG1-mediated H1.2 deposition at target promoters

Organsim human
Type RNASEQ
Target gene
Project ARCHS4

In this report we have discovered a new function of BRG1 during hormone-mediated gene repression. The ATPase BRG1 without the other subunits of the BAF complex is recruited by the hormone receptor to genomic sites marked by the pioneering factor FOXA1, where it remodels the target chromatin by interacting with linker histone H1.2 facilitating its deposition. SOURCE: Guillermo Vicent (guillermo.vicent@crg.eu) - CRG

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