PLX039132

GSE81441: Mutant p53 R270H induces invasion and metastasis of mouse intestinal tumor organoids through gain-of-function mechanism

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Apc(D716) mutant mice develop benign intestinal adenoma, while Apc(D716) and p53 R270H compound mutant mice develop invasive adenocarcinoma in the intestine. We examined expression profile of tumor-derived organoids using Apc(D716), Apc(D716) p53 Null, Apc(D716) p53 R270H mutant mice by RNA sequencing, and identified mutant p53-induced gene set. SOURCE: masanobu oshima (oshimam@staff.kanazawa-u.ac.jp) - kanazawa university

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