PLX280488

GSE80207: Transcriptome analysis in a radiosensitive and a radioresistant cell line after ionizing radiation

Organsim human
Type RNASEQ
Target gene
Project ARCHS4

Differential gene expression profiling was performed in two lymphoblastoid cell lines with different radiosentivitity, one radiosensitive (RS) and another radioresistant (RR), after different post-irradiation times. A greater and a prolonged transcriptional response after irradiation was induced in the RS cell line. Functional analysis showed that 24 h after irradiation genes involved in DNA damage response, negative regulation of the cell cycle and apoptosis were still differentially up-regulated in the RS cell line but not in the RR cell line. SOURCE: Mireia Borràs-Fresneda (mireiaborras2@gmail.com) - Universitat Autònoma de Barcelona

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