PLX098773

GSE79219: Ikaros regulates gene expression downstream of TCR signaling

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

The transcription factor Ikaros plays a critical role during lymphocyte differentiation, proliferation and activation. The deletion of Ikaros zinc finger 4 (Ikaros-Zn4-/-) results in the lowering of activation threshold and increased proliferation of mature T cells. Here we used CD8+ T cells from homozygous Ikaros-Zn4-/- mice to investigate its role in regulating gene expression downstream of T-cell receptor signaling. SOURCE: Ameya Champhekar6-535 MRL University of California, Los Angeles

View on GEOView in Pluto

Key Features

Enhance your research with our curated data sets and powerful platform features. Pluto Bio makes it simple to find and use the data you need.

Learn More

14K+ Published Experiments

Access an extensive range of curated bioinformatics data sets, including genomic, transcriptomic, and proteomic data.

Easy Data Import

Request imports from GEO or TCGA directly within Pluto Bio. Seamlessly integrate external data sets into your workflow.

Advanced Search Capabilities

Utilize powerful search tools to quickly find the data sets relevant to your research. Filter by type, disease, gene, and more.

Analyze and visualize data for this experiment

Use Pluto's intuitive interface to analyze and visualize data for this experiment. Pluto's platform is equipped with an API & SDKs, making it easy to integrate into your internal bioinformatics processes.

Read about post-pipeline analysis

View QC data and experiment metadata

View quality control data and experiment metadata for this experiment.

Request import of other GEO data

Request imports from GEO or TCGA directly within Pluto Bio.

Chat with our Scientific Insights team